F2SIK4 · LYSM2_TRIRC

Function

function

Secreted effector that binds two substrates, chitin and N-linked oligosaccharides associated with human skin glycoproteins (PubMed:30947244).
Could provide the pathogen with three important functions including shielding host cell wall chitin from the human immune system, shielding the pathogen's glycoproteins from host degradation and immune surveillance, and helping facilitate pathogen adhesion to human skin (Probable)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionchitin binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Secreted LysM effector LysM2
  • Alternative names
    • LysM domain-containing protein 2

Gene names

    • Name
      LysM2
    • ORF names
      TERG_01873

Organism names

Accessions

  • Primary accession
    F2SIK4

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_500328956922-360Secreted LysM effector LysM2
Glycosylation129N-linked (GlcNAc...) asparagine
Glycosylation204N-linked (GlcNAc...) asparagine

Keywords

Expression

Induction

Expression is induced during growth on Sabouraud medium containing glucose as carbon source, but not on keratin powder, nor on human nail fragments.

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain37-85LysM 1
Region94-125Disordered
Domain132-179LysM 2
Domain225-272LysM 3
Domain311-357LysM 4

Domain

The LysM (lysin motif) domains are small globular domains involved in binding chitin in eukaryotes. LysM2 contains 4 LysM domains.

Sequence similarities

Belongs to the secreted LysM effector family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    360
  • Mass (Da)
    38,692
  • Last updated
    2011-05-31 v1
  • Checksum
    4BADB58767C4815D
MKISSLSILPLLGVVSAGIHGKKPNGPTYAGTNPGCTWYLDLVDDSYTCENIESQWDLSHEAFVAWNPGVKKDCSGLKVGLSVCVEAPMESITATPTSEASTSSETSSASPTASRPPLPSPTQDGLVSNCTKFHQAVSGDTCSKIISRYKPITLDQFIEWNPALEKDCSGLWSGYYYCVGIPGTPSAPLTSMPASTAHSGTNSNATVKPAAPGPTQDGIANNCQRWHKAVSGNTCASLLKQYGTFTLEEFIKWNPAVGEDCSGLWLNYYYCIGIPGTPTTKNSVPKPTTTACNTPGLPSPTQPGAICQCSKWHQVRQGETCDSITRNYRISISKFKEWNPNVGKDCYGLWLRYYVCVGGK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GG700649
EMBL· GenBank· DDBJ
EGD85603.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp