F2SIK4 · LYSM2_TRIRC
- ProteinSecreted LysM effector LysM2
- GeneLysM2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids360 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Secreted effector that binds two substrates, chitin and N-linked oligosaccharides associated with human skin glycoproteins (PubMed:30947244).
Could provide the pathogen with three important functions including shielding host cell wall chitin from the human immune system, shielding the pathogen's glycoproteins from host degradation and immune surveillance, and helping facilitate pathogen adhesion to human skin (Probable)
Could provide the pathogen with three important functions including shielding host cell wall chitin from the human immune system, shielding the pathogen's glycoproteins from host degradation and immune surveillance, and helping facilitate pathogen adhesion to human skin (Probable)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | chitin binding |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSecreted LysM effector LysM2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Arthrodermataceae > Trichophyton
Accessions
- Primary accessionF2SIK4
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MKISSLSILPLLGVVSAGIHG | ||||||
Chain | PRO_5003289569 | 22-360 | Secreted LysM effector LysM2 | |||
Sequence: KKPNGPTYAGTNPGCTWYLDLVDDSYTCENIESQWDLSHEAFVAWNPGVKKDCSGLKVGLSVCVEAPMESITATPTSEASTSSETSSASPTASRPPLPSPTQDGLVSNCTKFHQAVSGDTCSKIISRYKPITLDQFIEWNPALEKDCSGLWSGYYYCVGIPGTPSAPLTSMPASTAHSGTNSNATVKPAAPGPTQDGIANNCQRWHKAVSGNTCASLLKQYGTFTLEEFIKWNPAVGEDCSGLWLNYYYCIGIPGTPTTKNSVPKPTTTACNTPGLPSPTQPGAICQCSKWHQVRQGETCDSITRNYRISISKFKEWNPNVGKDCYGLWLRYYVCVGGK | ||||||
Glycosylation | 129 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 204 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Expression
Induction
Expression is induced during growth on Sabouraud medium containing glucose as carbon source, but not on keratin powder, nor on human nail fragments.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 37-85 | LysM 1 | ||||
Sequence: TWYLDLVDDSYTCENIESQWDLSHEAFVAWNPGVKKDCSGLKVGLSVCV | ||||||
Region | 94-125 | Disordered | ||||
Sequence: ATPTSEASTSSETSSASPTASRPPLPSPTQDG | ||||||
Domain | 132-179 | LysM 2 | ||||
Sequence: KFHQAVSGDTCSKIISRYKPITLDQFIEWNPALEKDCSGLWSGYYYCV | ||||||
Domain | 225-272 | LysM 3 | ||||
Sequence: RWHKAVSGNTCASLLKQYGTFTLEEFIKWNPAVGEDCSGLWLNYYYCI | ||||||
Domain | 311-357 | LysM 4 | ||||
Sequence: KWHQVRQGETCDSITRNYRISISKFKEWNPNVGKDCYGLWLRYYVCV |
Domain
The LysM (lysin motif) domains are small globular domains involved in binding chitin in eukaryotes. LysM2 contains 4 LysM domains.
Sequence similarities
Belongs to the secreted LysM effector family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length360
- Mass (Da)38,692
- Last updated2011-05-31 v1
- Checksum4BADB58767C4815D
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GG700649 EMBL· GenBank· DDBJ | EGD85603.1 EMBL· GenBank· DDBJ | Genomic DNA |