F2RB79 · ADCS_STRVP
- ProteinAminodeoxychorismate synthase
- GenecmlB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids686 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Involved in chloramphenicol biosynthesis (PubMed:8704974).
Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine (By similarity).
Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine (By similarity).
Catalytic activity
- chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamateThis reaction proceeds in the forward direction.
Pathway
Antibiotic biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 81 | Nucleophile | |||
Active site | 168 | ||||
Active site | 170 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4-amino-4-deoxychorismate synthase activity | |
Biological Process | antibiotic biosynthetic process | |
Biological Process | folic acid-containing compound biosynthetic process | |
Biological Process | glutamine metabolic process | |
Biological Process | para-aminobenzoic acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameAminodeoxychorismate synthase
- EC number
- Short namesADC synthase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionF2RB79
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
Disruption of the gene decreases sulfanilamide resistance and blocks chloramphenicol production.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000447218 | 1-686 | Aminodeoxychorismate synthase | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 2-194 | Glutamine amidotransferase type-1 | |||
Region | 233-686 | PABB component | |||
Sequence similarities
In the C-terminal section; belongs to the anthranilate synthase component I family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length686
- Mass (Da)74,547
- Last updated2011-05-31 v1
- MD5 ChecksumEB49428D9D98E4251FB3F39CFDABDE90
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 14 | in Ref. 1; AAB30312 | |||
Sequence conflict | 29 | in Ref. 1; AAB30312 | |||
Sequence conflict | 91-99 | in Ref. 1; AAB30312 | |||
Sequence conflict | 163 | in Ref. 1; AAB30312 | |||
Sequence conflict | 168 | in Ref. 1; AAB30312 | |||
Sequence conflict | 201-202 | in Ref. 1; AAB30312 | |||
Sequence conflict | 222-226 | in Ref. 1; AAB30312 | |||
Sequence conflict | 244 | in Ref. 1; AAB30312 | |||
Sequence conflict | 280-284 | in Ref. 1; AAB30312 | |||
Sequence conflict | 294-297 | in Ref. 1; AAB30312 | |||
Sequence conflict | 329-331 | in Ref. 1; AAB30312 | |||
Sequence conflict | 387-389 | in Ref. 1; AAB30312 | |||
Sequence conflict | 418-429 | in Ref. 1; AAB30312 | |||
Sequence conflict | 460 | in Ref. 1; AAB30312 | |||
Sequence conflict | 466 | in Ref. 1; AAB30312 | |||
Sequence conflict | 507-508 | in Ref. 1; AAB30312 | |||
Sequence conflict | 558-560 | in Ref. 1; AAB30312 | |||
Sequence conflict | 601 | in Ref. 1; AAB30312 | |||
Sequence conflict | 616-617 | in Ref. 1; AAB30312 | |||
Sequence conflict | 664-665 | in Ref. 1; AAB30312 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U21728 EMBL· GenBank· DDBJ | AAB30312.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FR845719 EMBL· GenBank· DDBJ | CCA54207.1 EMBL· GenBank· DDBJ | Genomic DNA |