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F2RB79 · ADCS_STRVP

Function

function

Involved in chloramphenicol biosynthesis (PubMed:8704974).
Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine (By similarity).

Catalytic activity

Pathway

Antibiotic biosynthesis.

Features

Showing features for active site.

168650100150200250300350400450500550600650
TypeIDPosition(s)Description
Active site81Nucleophile
Active site168
Active site170

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4-amino-4-deoxychorismate synthase activity
Biological Processantibiotic biosynthetic process
Biological Processfolic acid-containing compound biosynthetic process
Biological Processglutamine metabolic process
Biological Processpara-aminobenzoic acid biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Aminodeoxychorismate synthase
  • EC number
  • Short names
    ADC synthase
  • Alternative names
    • 4-amino-4-deoxychorismate synthase
    • p-aminobenzoate synthase

Gene names

    • Name
      cmlB
    • Synonyms
      pabAB
    • Ordered locus names
      SVEN_0920

Organism names

Accessions

  • Primary accession
    F2RB79
  • Secondary accessions
    • Q56151

Proteomes

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Disruption of the gene decreases sulfanilamide resistance and blocks chloramphenicol production.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004472181-686Aminodeoxychorismate synthase

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain2-194Glutamine amidotransferase type-1
Region233-686PABB component

Sequence similarities

In the C-terminal section; belongs to the anthranilate synthase component I family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    686
  • Mass (Da)
    74,547
  • Last updated
    2011-05-31 v1
  • MD5 Checksum
    EB49428D9D98E4251FB3F39CFDABDE90
MRTLLIDNYDSFTHNLFQYIGEATGQPPVVVPNDADWSRLPLEDFDAIVVSPGPGSPDRERDFGISRRAITDSGLPVLGVCLGHQGIAQLFGGTVGLAPEPMHGRVSEVRHTGEDVFRGLPSPFTAVRYHSLAATDLPDELEPLAWSDDGVVMGLRHREKPLWGVQFHPESIGSDFGREIMANFRDLALAHHRARRDAADSPYELHVRRVDVLPDAEEVRRGCLPGEGATFWLDSSSVLEGASRFSFLGDDRGPLAEYLTYRVADGVVSVRGSDGTTTRTRRPFFSYLEEQLERRRVPVAPDLPFEFNLGYVGYLGYELKAETTGDPAHRSPHPDAAFLFADRAIALDHQEGCCYLLALDRRGHDDGARAWLRETAETLTGLAVRVPAEPTPAMVFGVPEAAAGFGPLARARHDKDAYLKRIDECLKEIRNGESYEICLTNMVTAPTEATALPLYSALRAISPVPYGALLEFPELSVLSASPERFLTIGADGGVESKPIKGTRPRGGTAEEDERLRADLAGREKDRAENLMIVDLVRNDLNSVCAIGSVHVPRLFEVETYAPVHQLVSTIRGRLRPGTSTAACVRAAFPGGSMTGAPKKRTMEIIDRLEEGPRGVYSGALGWFALSGAADLSIVIRTIVLADGRAEFGVGGAIVSLSDQEEEFTETVVKARAMVTALDGSAVAGAR

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict14in Ref. 1; AAB30312
Sequence conflict29in Ref. 1; AAB30312
Sequence conflict91-99in Ref. 1; AAB30312
Sequence conflict163in Ref. 1; AAB30312
Sequence conflict168in Ref. 1; AAB30312
Sequence conflict201-202in Ref. 1; AAB30312
Sequence conflict222-226in Ref. 1; AAB30312
Sequence conflict244in Ref. 1; AAB30312
Sequence conflict280-284in Ref. 1; AAB30312
Sequence conflict294-297in Ref. 1; AAB30312
Sequence conflict329-331in Ref. 1; AAB30312
Sequence conflict387-389in Ref. 1; AAB30312
Sequence conflict418-429in Ref. 1; AAB30312
Sequence conflict460in Ref. 1; AAB30312
Sequence conflict466in Ref. 1; AAB30312
Sequence conflict507-508in Ref. 1; AAB30312
Sequence conflict558-560in Ref. 1; AAB30312
Sequence conflict601in Ref. 1; AAB30312
Sequence conflict616-617in Ref. 1; AAB30312
Sequence conflict664-665in Ref. 1; AAB30312

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U21728
EMBL· GenBank· DDBJ
AAB30312.1
EMBL· GenBank· DDBJ
Genomic DNA
FR845719
EMBL· GenBank· DDBJ
CCA54207.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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