F2F738 · F2F738_SOLSS

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Features

Showing features for binding site, active site.

111441002003004005006007008009001,0001,100
Type
IDPosition(s)Description
Binding site119ATP (UniProtKB | ChEBI)
Binding site203ATP (UniProtKB | ChEBI)
Binding site238ATP (UniProtKB | ChEBI)
Active site294
Binding site541Mn2+ (UniProtKB | ChEBI)
Binding site613substrate
Binding site710Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site739Mn2+ (UniProtKB | ChEBI)
Binding site741Mn2+ (UniProtKB | ChEBI)
Binding site874substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • Ordered locus names
      SSIL_3134

Organism names

Accessions

  • Primary accession
    F2F738

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue710N6-carboxylysine
Modified residue1110N6-biotinyllysine

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-455Biotin carboxylation
Domain125-319ATP-grasp
Domain532-800Pyruvate carboxyltransferase
Domain1069-1144Lipoyl-binding

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,144
  • Mass (Da)
    127,292
  • Last updated
    2011-05-31 v1
  • MD5 Checksum
    998E9AE3BF5DBBC7F70497CFD619995A
MKSIQKILVANRGEIAIRILRACNELHIKTVAIYSREDSGSYHRYKADEAYIVGVGKKPIDAYLDIEGIIKIAKEANVDAIHPGYGFLSENVDFARRCEEEGIQFIGPTSKHLDMFGDKVKAREQAVSAQIPVIPGTDGPVANLQEVEQFSDSYGFPIMIKAALGGGGRGMRLVNSKEELQSAYERAKSEAKAAFGSDEVYVEKAIIKPKHIEVQIIGDTHGNIVHLYERDCSIQRRHQKVVEIAPSNSISEQLRNDICDAAVKLMKNVGYINAGTVEFLVADNQFYFIEVNPRIQVEHTITEMITGLDIVHAQIKVAEGLDLHSKEVGIPAQDKIPLFGYAIQSRVTTEDPANDFMPDTGKLMVYRSSGGFGVRLDAGNGFQGAVVTPYYDSLLVKISTWGMTFEEAAAKMDRNLREFRIRGVKTNIPFLGNVVLHEKFIKGEFDTSFIDTTPELFEFPERKDRGTKLLNYIGNVTLNGFPGVEKRTKPIFVQPDKPKLDILIPSPAGTKQILEAQGADGLVKWIKEQEDVLLTDTTFRDAHQSLLATRVRTQDMLEIADETSRLMHDYFSLEMWGGATFDVAYRFLSENPWDRLEKLRKKIPNVLFQMLLRGANAVGYTNYPDNLIREFIQESASSGVDVFRIFDSLNWIKGMEVAIDEVRNSGKVAEAAICYTGDILDDSRAKYTVQYYKDMARELEATGAHILAIKDMAGLLKPQAAYRLISELKDATSLPIHLHTHDTSGNGIFLYAKAIEAGVDIIDTALGSMAGLTSQPSANSLYYAMKGSERNVRGDIECLEKLSYYWEDVRKYYVDFESGMNAPHSEIYVHEMPGGQYSNLQQQAKAVGLGDRWDEVKTMYSRVNLMFGDIVKVTPSSKVVGDMALFMVQNDLTEDNIVGRGQTIDFPESVIEFFQGYLGQPHGGFPEEIQKVVLKDRTPITVRPGELLPPVDFDQLTAELTEKYGRAPSKQDVLAYALYPKVFEQYIDAVNAFGDVSVLDTPTFFYGLKIGEEIEVEIEKGKTLIVKLVSIGEPQHDGTRIIYFELNGQSRELVIQDLTVEVDGSIALKADPSNPNQIGATMPGTVLKVVVNKGSTVKRGEHLLITEAMKMETTVQAPKDGIVKEIYAKAGDAISTGDLLIELE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP012157
EMBL· GenBank· DDBJ
BAK17557.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice.
Help