F2CCR8 · F2CCR8_STRSA
- ProteinFluoride-specific ion channel FluC
- GenecrcB2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids124 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Catalytic activity
- fluoride(in) = fluoride(out)This reaction proceeds in the forward direction.
Activity regulation
Na+ is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 76 | Na+ (UniProtKB | ChEBI); structural | |||
Binding site | 79 | Na+ (UniProtKB | ChEBI); structural | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | fluoride channel activity | |
Molecular Function | metal ion binding | |
Biological Process | cellular detoxification of fluoride |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameFluoride-specific ion channel FluC
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionF2CCR8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 7-30 | Helical | |||
Transmembrane | 36-54 | Helical | |||
Transmembrane | 66-85 | Helical | |||
Transmembrane | 100-119 | Helical | |||
Keywords
- Cellular component
Structure
Sequence
- Sequence statusComplete
- Length124
- Mass (Da)13,260
- Last updated2011-05-31 v1
- Checksum4D53253598957D72
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AFBE01000002 EMBL· GenBank· DDBJ | EGF19828.1 EMBL· GenBank· DDBJ | Genomic DNA |