F2CCR8 · F2CCR8_STRSA

Function

function

Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Na+ is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site76Na+ (UniProtKB | ChEBI); structural
Binding site79Na+ (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionfluoride channel activity
Molecular Functionmetal ion binding
Biological Processcellular detoxification of fluoride

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fluoride-specific ion channel FluC

Gene names

    • Name
      crcB2
    • Synonyms
      crcB
      , fluC
    • ORF names
      HMPREF9391_0548

Organism names

Accessions

  • Primary accession
    F2CCR8

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane7-30Helical
Transmembrane36-54Helical
Transmembrane66-85Helical
Transmembrane100-119Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    124
  • Mass (Da)
    13,260
  • Last updated
    2011-05-31 v1
  • Checksum
    4D53253598957D72
MKEVQNSIAVALSAMVGGWLRYQIALLLVVADSFPLGTLLVNYLGTFLLVYIIKGYLSSKVKSQRLILALSTGFCGGLTTFSGLLLDSIKLADSGRYMELLIYLVLSVGGGLAIALWAGKQVKS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AFBE01000002
EMBL· GenBank· DDBJ
EGF19828.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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