F1YET5 · F1YET5_9ACTN
- ProteinCytochrome c oxidase subunit 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids557 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | oxidative phosphorylation | |
Biological Process | respiratory electron transport chain |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Gordoniaceae > Gordonia
Accessions
- Primary accessionF1YET5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 33-52 | Helical | ||||
Sequence: MYITTCIAFFLIGGLMALLM | ||||||
Transmembrane | 72-99 | Helical | ||||
Sequence: LFTMHGTVMLLMYATPIVIGFANFVLPL | ||||||
Transmembrane | 111-131 | Helical | ||||
Sequence: LNALGYWLFLFGNLVALGGFL | ||||||
Transmembrane | 160-186 | Helical | ||||
Sequence: FWIMGLGVAGLGTILGAVNMITTVVCL | ||||||
Transmembrane | 198-224 | Helical | ||||
Sequence: IFTWNILVTSVLILLIFPLLTAALMGL | ||||||
Transmembrane | 244-268 | Helical | ||||
Sequence: LWQHLFWFFGHPEVYVIALPFFGIV | ||||||
Transmembrane | 280-301 | Helical | ||||
Sequence: TFGYSGLVYATLAIAALSVAVW | ||||||
Transmembrane | 307-329 | Helical | ||||
Sequence: VTGSVLLPFFSFMTFLIAVPTGV | ||||||
Transmembrane | 350-370 | Helical | ||||
Sequence: LFAIGFIVTFLFGGLTGVLLA | ||||||
Transmembrane | 390-408 | Helical | ||||
Sequence: YVLFGTIVFATFSGIYFWF | ||||||
Transmembrane | 420-442 | Helical | ||||
Sequence: LGKWHFWLTFIGFHTTFLVQHWL | ||||||
Transmembrane | 462-483 | Helical | ||||
Sequence: TLNVVSTVGAFILGLSTLPFVW |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 13-527 | Cytochrome oxidase subunit I profile | ||||
Sequence: PKGSFFYKLITTTDHKLIGQMYITTCIAFFLIGGLMALLMRAELTHPGLQFLSNEQFNQLFTMHGTVMLLMYATPIVIGFANFVLPLQIGAPDVAFPRLNALGYWLFLFGNLVALGGFLTPGGAADFGWTAYTPLTDAVHSPGVGADFWIMGLGVAGLGTILGAVNMITTVVCLRAPGMTMFRMPIFTWNILVTSVLILLIFPLLTAALMGLEVDRQFGAHLYDPANGGVILWQHLFWFFGHPEVYVIALPFFGIVSEVFPVFSRKPTFGYSGLVYATLAIAALSVAVWAHHMYVTGSVLLPFFSFMTFLIAVPTGVKFFNWIGTMWKGRITFETPMLFAIGFIVTFLFGGLTGVLLASPPLDFHISDTYFVVAHFHYVLFGTIVFATFSGIYFWFPKMTGRMLDETLGKWHFWLTFIGFHTTFLVQHWLGNEGMPRRYADYLPSDGFTTLNVVSTVGAFILGLSTLPFVWNVFKSYRYGEVVTVDDPWGFGNGLEWATSCPPPRHNFTELPRIR |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length557
- Mass (Da)62,347
- Last updated2011-05-31 v1
- ChecksumDBD470ADF9A066BB