F1T0K3 · F1T0K3_HUMAN
- ProteinPhosphodiesterase
- GenePDE6A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids779 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Cofactor
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 478 | Proton donor | |||
Binding site | 478-482 | AMP (UniProtKB | ChEBI) | |||
Binding site | 482 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 518 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 519 | AMP (UniProtKB | ChEBI) | |||
Binding site | 519 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 519 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 639 | AMP (UniProtKB | ChEBI) | |||
Binding site | 639 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 692 | AMP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 3',5'-cyclic-nucleotide phosphodiesterase activity | |
Molecular Function | metal ion binding | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionF1T0K3
Proteomes
Organism-specific databases
Disease & Variants
Variants
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The viewer provides 1,061 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Genetic variation databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 402-735 | PDEase | |||
Region | 740-779 | Disordered | |||
Compositional bias | 751-779 | Polar residues | |||
Sequence similarities
Belongs to the cyclic nucleotide phosphodiesterase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length779
- Mass (Da)90,132
- Last updated2011-05-31 v1
- ChecksumC613346F01C33FB3
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P16499 | PDE6A_HUMAN | PDE6A | 860 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 751-779 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC008427 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC008545 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AB593141 EMBL· GenBank· DDBJ | BAJ84077.1 EMBL· GenBank· DDBJ | mRNA |