F1T0K3 · F1T0K3_HUMAN

  • Protein
    Phosphodiesterase
  • Gene
    PDE6A
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.

Features

Showing features for active site, binding site.

1779100200300400500600700
Type
IDPosition(s)Description
Active site478Proton donor
Binding site478-482AMP (UniProtKB | ChEBI)
Binding site482Zn2+ 1 (UniProtKB | ChEBI)
Binding site518Zn2+ 1 (UniProtKB | ChEBI)
Binding site519AMP (UniProtKB | ChEBI)
Binding site519Zn2+ 1 (UniProtKB | ChEBI)
Binding site519Zn2+ 2 (UniProtKB | ChEBI)
Binding site639AMP (UniProtKB | ChEBI)
Binding site639Zn2+ 1 (UniProtKB | ChEBI)
Binding site692AMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function3',5'-cyclic-nucleotide phosphodiesterase activity
Molecular Functionmetal ion binding
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphodiesterase
  • EC number

Gene names

    • Name
      PDE6A

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    F1T0K3

Proteomes

Organism-specific databases

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,061 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Genetic variation databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain402-735PDEase
Region740-779Disordered
Compositional bias751-779Polar residues

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    779
  • Mass (Da)
    90,132
  • Last updated
    2011-05-31 v1
  • Checksum
    C613346F01C33FB3
MGEVTAEEVEKFLDSNIGFAKQYYNLHYRAKLISDLLGAKEAAVDFSNYHSPSSMEESEIIFDLLRDFQENLQTEKCIFNVMKKLCFLLQADRMSLFMYRTRNGIAELATRLFNVHKDAVLEDCLVMPDQEIVFPLDMGIVGHVAHSKKIANVPNTEEILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEVPPYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPAYVAQNGLICNIMNAPAEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQAELPDADKYEINKFHFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRKITYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESEQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSQVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYDAKMKVQEEKKQKQQSAKSAAAGNQPGGNPSPGGATTSKSCCIQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
P16499PDE6A_HUMANPDE6A860

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias751-779Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC008427
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC008545
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AB593141
EMBL· GenBank· DDBJ
BAJ84077.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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