F1RE57 · DHC3A_DANRE

Function

function

Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and regulates their association with membranes (Probable). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (Probable).

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site155S-palmitoyl cysteine intermediate

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi membrane
Molecular Functionprotein homodimerization activity
Molecular Functionprotein-cysteine S-myristoyltransferase activity
Molecular Functionprotein-cysteine S-palmitoyltransferase activity
Molecular Functionprotein-cysteine S-stearoyltransferase activity
Molecular FunctionS-acyltransferase activity
Biological Processpeptidyl-L-cysteine S-palmitoylation
Biological Processprotein palmitoylation
Biological Processprotein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Palmitoyltransferase ZDHHC3-A
  • EC number
  • Alternative names
    • Acyltransferase ZDHHC3A
      (EC:2.3.1.-
      ) . EC:2.3.1.- (UniProtKB | ENZYME | Rhea)
    • Zinc finger DHHC domain-containing protein 3

Gene names

    • Name
      zdhhc3a
    • Synonyms
      dhhc3
      , zdhhc3

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    F1RE57
  • Secondary accessions
    • Q6DH92

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-45Cytoplasmic
Transmembrane46-66Helical
Topological domain67-70Lumenal
Transmembrane71-91Helical
Topological domain92-169Cytoplasmic
Transmembrane170-190Helical
Topological domain191-212Lumenal
Transmembrane213-233Helical
Topological domain234-316Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, lipidation.

TypeIDPosition(s)Description
ChainPRO_00004495311-316Palmitoyltransferase ZDHHC3-A
Lipidation144S-palmitoyl cysteine

Post-translational modification

Autopalmitoylated.

Keywords

Proteomic databases

Expression

Developmental stage

Probably maternally supplied, the zygotic expression is detected early during development at the sphere stage but decreases after 7.5 hpf.

Gene expression databases

Interaction

Subunit

Monomer. Homooligomers. The monomeric form has a higher catalytic activity. Forms heterooligomers with zdhhc7.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain124-175DHHC

Domain

The DHHC domain is required for palmitoyltransferase activity.

Sequence similarities

Belongs to the DHHC palmitoyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    316
  • Mass (Da)
    35,892
  • Last updated
    2011-05-03 v1
  • Checksum
    103F2BED563EE62F
MRSPVPRFRDVERQASGLQPPQCLPSCHERQSSMWFIKDACGIVCAIITWFLVFFAEFVVLFVMLIPSKNLTYSLVNGTLFNSLAFLALASHFRAMCTDPGAVPKGNATKEYIESLQLKPGQVVYKCPKCCSIKPDRAHHCSVCKRCIRKMDHHCPWVNNCVGENNQKYFVLFTMYICLISLHSLVMVVFHFLNCFEDDWTKCSTFSPPATVILLILLCFEGLLFLIFTSVMFGTQVHSICTDETGIEKLKREDPTWEKTQCWEGMKSAFGGPLSVTWFSPFTDLSCQKDDSSPVPMFPQGEIIEEDVIEIPLEPH

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M2B4K7A0A8M2B4K7_DANREzdhhc3a297

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict32in Ref. 2; AAH76087

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR925805
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC076087
EMBL· GenBank· DDBJ
AAH76087.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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