F1RD85 · LOX3A_DANRE

Function

function

Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins. Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin. Can mediate oxidation of lysine residues that are acetylated. Also able to catalyze deacetylation of lysine residues (By similarity).

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

lysine tyrosylquinone residue (UniProtKB | Rhea| CHEBI:20489 )

Note: Contains 1 lysine tyrosylquinone.

GO annotations

AspectTerm
Cellular Componentcollagen-containing extracellular matrix
Cellular Componentcytoplasm
Cellular Componentextracellular space
Cellular Componentmembrane
Cellular Componentnucleus
Molecular Functioncopper ion binding
Molecular Functionfibronectin binding
Molecular Functionprotein-lysine 6-oxidase activity
Biological Processcollagen fibril organization
Biological Processfibronectin fibril organization
Biological Processinflammatory response
Biological Processlung development
Biological Processnegative regulation of T-helper 17 cell lineage commitment
Biological Processpeptidyl-lysine oxidation
Biological Processpositive regulation of integrin-mediated signaling pathway
Biological Processroof of mouth development
Biological Processsomite development
Biological Processspinal cord development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lysyl oxidase homolog 3A
  • EC number
  • Alternative names
    • Lysyl oxidase-like protein 3A

Gene names

    • Name
      loxl3a

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    F1RD85
  • Secondary accessions
    • A6MH32
    • X1WBP7

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus
Note: It is unclear how loxl3a is both intracellular (cytoplasmic and nuclear) and extracellular: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, the intracellular location is clearly reported and at least another protein of the family (loxl2) also has intracellular and extracellular localization despite the presence of a signal sequence.

Keywords

Phenotypes & Variants

Disruption phenotype

No visible phenotype.

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, cross-link, modified residue.

TypeIDPosition(s)Description
Signal1-25
ChainPRO_500326923826-739Lysyl oxidase homolog 3A
Disulfide bond64↔128
Disulfide bond77↔138
Disulfide bond108↔118
Disulfide bond196↔261
Disulfide bond209↔271
Disulfide bond238↔248
Glycosylation256N-linked (GlcNAc...) asparagine
Disulfide bond318↔382
Disulfide bond331↔392
Disulfide bond362↔372
Disulfide bond433↔497
Disulfide bond446↔510
Glycosylation468N-linked (GlcNAc...) asparagine
Disulfide bond479↔489
Glycosylation611N-linked (GlcNAc...) asparagine
Cross-link620↔656Lysine tyrosylquinone (Lys-Tyr)
Modified residue6562',4',5'-topaquinone

Post-translational modification

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

Weakly expressed at 30 hours post fertilization (hpf) in the ventral head mesenchyme, but not spatially restricted after this time-point.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain38-139SRCR 1
Domain166-272SRCR 2
Domain293-393SRCR 3
Domain403-511SRCR 4

Sequence similarities

Belongs to the lysyl oxidase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    739
  • Mass (Da)
    82,133
  • Last updated
    2011-05-03 v1
  • Checksum
    4EC48A1F52FF06D7
MLRSELRDMVVAMVLWGILLPFCLSQTTSPSQDGKIKFRLAGYPRKHNEGRIEVFYNREWGTICDDDFTLANAHVLCRQLGFVEALSWSHSAKYGPGSGKIWLDNVICGGSENSIEKCVSRGWGNSDCTHQEDAGVICKDERLPGFAESNIIEMQVDEKRMEKIRLRPLKGAHAGRLPVTEGVVEVKFKEGWGHICNTGWTIKNSRVVCGMMGFPSQRSVGKKPNSLKSAYRIHSVTCSGNEAHLSACTMEFSRANSSAPCPGGGAAVVSCVPGLQFTQGRVRKAKLNPVPQMRLKGGARAGEGRVEVLKGSEWGTVCDDHWNLQSASVVCRELGFGTAKEALTGARMGQGMGPIYMNEVQCGGDEKSLWDCPHQSITAEDCKHTEDASVICNIPYMGFEKLMRLTGGRTRLEGRVELLLPAGGGVRDWGLICGDGWTSREAMVVCRQLGLGHASSGLRETWYWDSSNVTEMVMSGVKCKGDEMTLTDCQHHSVVSCKRAGAQFSAGVICSDMASDLVLNAPLVEQTVYIEDRPLHLLYCAAEENCLAKSAAQASWPYGHRRLLRFSSEIHNIGKADFRPRLGRHSWVWHECHRHYHSMDIFTYYDLLSLNGTKVADGHKASFCLEDTECHEGVSKRYECANFGEQGITVGCWDLYRHDIDCQWIDITDVSPGNYILQVIINPNFEVAESDFTNNAMRCNCKYDGHRVWLHKCHLGDSFSEEAEKEFEHYPGQLNNKIS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5H1ZRI5A0A5H1ZRI5_DANREloxl3a791

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FP085411
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
FP085432
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
EF030483
EMBL· GenBank· DDBJ
ABM86969.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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