F1R9Y7 · F1R9Y7_DANRE

Function

function

NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

FMN (UniProtKB | Rhea| CHEBI:58210 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site12-17FMN (UniProtKB | ChEBI)
Binding site59-62FMN (UniProtKB | ChEBI)
Binding site97-106FMN (UniProtKB | ChEBI)
Binding site132FMN (UniProtKB | ChEBI)
Binding site348FAD (UniProtKB | ChEBI)
Binding site380-383FAD (UniProtKB | ChEBI)
Binding site414-417FAD (UniProtKB | ChEBI)
Binding site458NADP+ (UniProtKB | ChEBI)
Binding site513-514NADP+ (UniProtKB | ChEBI)
Binding site519-523NADP+ (UniProtKB | ChEBI)
Binding site594FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentperinuclear region of cytoplasm
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular FunctionNADP binding
Molecular FunctionNADPH-hemoprotein reductase activity
Biological Processiron-sulfur cluster assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADPH-dependent diflavin oxidoreductase 1
  • EC number
  • Alternative names
    • NADPH-dependent FMN and FAD-containing oxidoreductase

Gene names

    • Name
      ndor1
    • Synonyms
      NDOR1
      , wu:fc41f01
      , zgc:66159

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    F1R9Y7
  • Secondary accessions
    • A0A8M3ASF5

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm, perinuclear region
Note: Concentrated in perinuclear structure.

Keywords

Expression

Gene expression databases

Interaction

Subunit

Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-150Flavodoxin-like
Domain204-444FAD-binding FR-type

Sequence similarities

Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.
In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.
In the N-terminal section; belongs to the flavodoxin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    595
  • Mass (Da)
    66,706
  • Last updated
    2011-05-03 v1
  • Checksum
    BA653DEED3E555D6
MSGHTVLVLYGSQTGTAQDTAERIGRQAQRRRLRVKAEALDTYNVANLISESLVVFVCATTGQGDPPDNMKKFWRFLFRKSLPADSLSRLDCAVLGLGDSSYPKFNFVAKKLHKRLLQLGANMLLPVGLADDQHDLGPDGVIDPWLLSFWQKTLSLYPPPAGLAPLREEDKLPPRYIFHFLSEVPNKPTEHLQTVDNKSSPTSLRPFPAPLVFNQRVTHTAHFQDVRHIEFDITGSNIEFSAGDIVMMRPCNTAEDVEQLCQLLKLDPESYFTLTPTDSSTEVPARLPQPCSVRFLLEHFLDISAVPRRSFFELLATFATDELEQEKLLEFSSAAGQDALHSYCNRPRRTAIEVLTDFPHTTAELSIGCLLDLFPEIQPRSFSIASSLLEHPNRIQILLAVVKYKTMLVKPRKGLCSSWLASLDPSKGDVYVPLWVKKGSLKFPQDPESPVIMVGPGTGVAPFRSAIQERVAQGKMANVLFFGCRSESKDFYCGSEWQEKVQAGQMILVTAFSRDQEDKVYVQHRVKEQGKLLWDLIAKKNAFFYIAGNAKQMPTSVCDALKAVFQKEGGMSENQAQEMLDGMEKNGRFQSETWS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q6PFP6NDOR1_DANREndor1595

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FP102160
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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