F1R8E2 · F1R8E2_DANRE

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionhedgehog family protein binding
Molecular Functionhedgehog receptor activity
Molecular Functionsmoothened binding
Biological Processcardioblast differentiation
Biological Processintramembranous ossification
Biological Processnegative regulation of muscle organ development
Biological Processnegative regulation of smoothened signaling pathway
Biological Processosteoblast differentiation
Biological Processretina development in camera-type eye
Biological Processretina morphogenesis in camera-type eye

Keywords

  • Molecular function

Names & Taxonomy

Protein names

  • Submitted names
    • Protein patched homolog 1

Gene names

    • Name
      ptch1
    • Synonyms
      lep
      , ptc1
      , ptc2

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    F1R8E2
  • Secondary accessions
    • A0A8M1P6A6

Proteomes

    • Identifier
    • Component
      Alternate scaffold 8, Chromosome 8

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane428-447Helical
Transmembrane459-484Helical
Transmembrane490-512Helical
Transmembrane533-556Helical
Transmembrane562-585Helical
Transmembrane1041-1062Helical
Transmembrane1068-1090Helical
Transmembrane1097-1123Helical
Transmembrane1135-1155Helical
Transmembrane1167-1192Helical

Keywords

  • Cellular component

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-26Disordered
Domain427-587SSD
Region623-642Disordered
Region676-722Disordered
Region1200-1246Disordered
Compositional bias1222-1246Polar residues
Region1278-1391Disordered
Compositional bias1293-1316Polar residues
Compositional bias1321-1346Basic and acidic residues
Compositional bias1408-1433Polar residues
Region1408-1475Disordered
Compositional bias1434-1459Basic and acidic residues

Sequence similarities

Belongs to the patched family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,475
  • Mass (Da)
    163,916
  • Last updated
    2018-06-20 v2
  • Checksum
    46E6493C49DFD499
MASAVNVSSEQENRDPDRPRVTRRNRGNYRTAAADLEYLQRPSYCDAAFALEQISEGNATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLRAANLETDVEKLWVEVGGRVNQELKYTRQKIGEEAMFSPQLMIQTPRQEGANILTVEALKQHLDSAIKASRVHVYMYNRQWTLEHLCYKSGELVTETNVVDQILEKLHPCLVITPLDCFWEGAKLHSGTFYLPGKPPLQWTNFDPMGFIAELKMLKYQVDSWEEMLVKADVGQGYMNRPCLNPADPDCPLSAPNKNTTGPFDVAPVLTGGCYGLSKKYMHWQEELIVGGTKKNDSGKLLSAQAFQTMFQLMTPKQMYEHLKGYDEVSHINWNEDKAAAILEAWQRKYSEAVQQSVPVNSSQKVLTFTTTTLEDILKSFSDVSVIRIASGYLLMLAYACLTMLRWDCAKSQGAVGLAGVLLVTLSVAAGLGLCSLLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRFDIFCCFVSPCANRVIQLEPQAAYADSSADSSRYSPPPSYSSHSFAQHTQITMQSTVQLRTEYDPRTQAYYTTAEPHSHISVQPYAPNTNPNPNPNRNNNNNNCTNNSSSAVPGVATDTASCQSPDGASSTRDLLSQFGDSGIRCLDSPYSRWTFASFAEKHYAPFLLQSTTKVVVIFLFLALLGVSLYGTTRVRDGLELTDIVPRETGEYDFIRAQFRYFSFYNMYVVTQRADYAQIQPQLYELHQRFGSVKYILREENGQLPRMWLHYFRDWLLGLQEAFDKDWQAGRITQGNYRNGSDDGVLAYKLLVQTGRREKTITRQRLVSADGIINPNAFYIYLSAWVSNDPVAYAASQANIRPHPPEWLHDRTDSIPASRLNIPAAEPIEYAQFPFYLNGLRETPQFVEAIESVRAICNNFSRQGLPSYPNGYPFLFWEQYVGLRHWLLLSISVVLACTFLVCAVFLLNPWTAGIIVLVLSLMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDRNKRAVLALEHMFAPVLDGAFSTLLGVLMLAGSEFDFIVRYFFAVLAILTVLGVLNGLVLLPVLLSYFGPYPEVSPADGQSRLPTPSPEPPPQVVRFTMRPSHTTPGAGSDSSDSEYGSNTTVSGISQELQQYNLQPNRGRSARLEEVRIATAGRQGSRQVELPMFPSCSDDSRQQQIQQHYRSSSHDAAPQPSKRYCSRDPKRDFGSGHPPPPHRPRMDAFETATEPGGHSGPNHRDRSGAHRPRSHNPYNPHPSHPSTGPNYCQPITTVTASASVTVAVHSGVPSQSPAYPSYPSNDSYQTSGDVHNDPHFSDPHVPFDESHDSSKVEGMELQDLEYDTANVCHTRPSS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1222-1246Polar residues
Compositional bias1293-1316Polar residues
Compositional bias1321-1346Basic and acidic residues
Compositional bias1408-1433Polar residues
Compositional bias1434-1459Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR376747
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CR382329
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CR847548
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CT027671
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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