F1R8E2 · F1R8E2_DANRE
- ProteinProtein patched homolog 1
- Geneptch1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1475 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | hedgehog family protein binding | |
Molecular Function | hedgehog receptor activity | |
Molecular Function | smoothened binding | |
Biological Process | cardioblast differentiation | |
Biological Process | intramembranous ossification | |
Biological Process | negative regulation of muscle organ development | |
Biological Process | negative regulation of smoothened signaling pathway | |
Biological Process | osteoblast differentiation | |
Biological Process | retina development in camera-type eye | |
Biological Process | retina morphogenesis in camera-type eye |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionF1R8E2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 428-447 | Helical | ||||
Sequence: VIRIASGYLLMLAYACLTML | ||||||
Transmembrane | 459-484 | Helical | ||||
Sequence: GLAGVLLVTLSVAAGLGLCSLLGISF | ||||||
Transmembrane | 490-512 | Helical | ||||
Sequence: QVLPFLALGVGVDDVFLLAHAFS | ||||||
Transmembrane | 533-556 | Helical | ||||
Sequence: TGASVALTSISNVTAFFMAALIPI | ||||||
Transmembrane | 562-585 | Helical | ||||
Sequence: FSLQAAVVVVFNFAMVLLIFPAIL | ||||||
Transmembrane | 1041-1062 | Helical | ||||
Sequence: WLLLSISVVLACTFLVCAVFLL | ||||||
Transmembrane | 1068-1090 | Helical | ||||
Sequence: GIIVLVLSLMTVELFGMMGLIGI | ||||||
Transmembrane | 1097-1123 | Helical | ||||
Sequence: VVILIASVGIGVEFTVHVALAFLTAIG | ||||||
Transmembrane | 1135-1155 | Helical | ||||
Sequence: HMFAPVLDGAFSTLLGVLMLA | ||||||
Transmembrane | 1167-1192 | Helical | ||||
Sequence: FAVLAILTVLGVLNGLVLLPVLLSYF |
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-26 | Disordered | ||||
Sequence: MASAVNVSSEQENRDPDRPRVTRRNR | ||||||
Domain | 427-587 | SSD | ||||
Sequence: SVIRIASGYLLMLAYACLTMLRWDCAKSQGAVGLAGVLLVTLSVAAGLGLCSLLGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSM | ||||||
Region | 623-642 | Disordered | ||||
Sequence: SSADSSRYSPPPSYSSHSFA | ||||||
Region | 676-722 | Disordered | ||||
Sequence: ISVQPYAPNTNPNPNPNRNNNNNNCTNNSSSAVPGVATDTASCQSPD | ||||||
Region | 1200-1246 | Disordered | ||||
Sequence: PADGQSRLPTPSPEPPPQVVRFTMRPSHTTPGAGSDSSDSEYGSNTT | ||||||
Compositional bias | 1222-1246 | Polar residues | ||||
Sequence: TMRPSHTTPGAGSDSSDSEYGSNTT | ||||||
Region | 1278-1391 | Disordered | ||||
Sequence: GRQGSRQVELPMFPSCSDDSRQQQIQQHYRSSSHDAAPQPSKRYCSRDPKRDFGSGHPPPPHRPRMDAFETATEPGGHSGPNHRDRSGAHRPRSHNPYNPHPSHPSTGPNYCQP | ||||||
Compositional bias | 1293-1316 | Polar residues | ||||
Sequence: CSDDSRQQQIQQHYRSSSHDAAPQ | ||||||
Compositional bias | 1321-1346 | Basic and acidic residues | ||||
Sequence: YCSRDPKRDFGSGHPPPPHRPRMDAF | ||||||
Compositional bias | 1408-1433 | Polar residues | ||||
Sequence: GVPSQSPAYPSYPSNDSYQTSGDVHN | ||||||
Region | 1408-1475 | Disordered | ||||
Sequence: GVPSQSPAYPSYPSNDSYQTSGDVHNDPHFSDPHVPFDESHDSSKVEGMELQDLEYDTANVCHTRPSS | ||||||
Compositional bias | 1434-1459 | Basic and acidic residues | ||||
Sequence: DPHFSDPHVPFDESHDSSKVEGMELQ |
Sequence similarities
Belongs to the patched family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,475
- Mass (Da)163,916
- Last updated2018-06-20 v2
- Checksum46E6493C49DFD499
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1222-1246 | Polar residues | ||||
Sequence: TMRPSHTTPGAGSDSSDSEYGSNTT | ||||||
Compositional bias | 1293-1316 | Polar residues | ||||
Sequence: CSDDSRQQQIQQHYRSSSHDAAPQ | ||||||
Compositional bias | 1321-1346 | Basic and acidic residues | ||||
Sequence: YCSRDPKRDFGSGHPPPPHRPRMDAF | ||||||
Compositional bias | 1408-1433 | Polar residues | ||||
Sequence: GVPSQSPAYPSYPSNDSYQTSGDVHN | ||||||
Compositional bias | 1434-1459 | Basic and acidic residues | ||||
Sequence: DPHFSDPHVPFDESHDSSKVEGMELQ |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR376747 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR382329 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CR847548 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CT027671 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |