F1R3C6 · F1R3C6_DANRE

Function

function

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: The zinc ions have a structural role.

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentnucleus
Molecular Function5-methylcytosine dioxygenase activity
Molecular FunctionDNA binding
Molecular Functionzinc ion binding
Biological Process5-methylcytosine catabolic process
Biological Processcellular response to lipopolysaccharide
Biological Processchromosomal 5-methylcytosine DNA demethylation pathway
Biological Processepigenetic regulation of gene expression
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of interleukin-13 production
Biological Processresponse to hypoxia

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylcytosine dioxygenase TET
  • EC number

Gene names

    • Name
      tet1

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    F1R3C6
  • Secondary accessions
    • W0D440

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region32-60Disordered
Region81-107Disordered
Region132-213Disordered
Compositional bias158-180Basic and acidic residues
Region267-286Disordered
Region304-331Disordered
Domain445-486CXXC-type
Compositional bias746-761Polar residues
Region746-765Disordered
Compositional bias1540-1583Polar residues
Region1540-1662Disordered
Compositional bias1591-1635Polar residues
Compositional bias1643-1662Basic and acidic residues
Region1784-1817Disordered

Sequence similarities

Belongs to the TET family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,855
  • Mass (Da)
    206,332
  • Last updated
    2011-05-03 v1
  • Checksum
    5941B66D32A9D706
MSTLILLQTGSITLKVQFLRRPQYCFSCRLSQTPPPSPSLTSAMPRTAKAPKKSTRASTKRNVKRVKASMTRRQTINSLKASGEIKKGIDKKQAAKRAQRTVVSKPNKKTVEDVLPVKISRHTTSSLNQNGLLLECNGKGKSPRKSVSCPSIQRDVQKKGAQEIREQETETKRSEVNDPNGDAEQQKGAEIPTGEGQSVNISSKESGEEHRETVVNDTLVAEKKKVKVNTETVQSESYSAVVEQPNTVFVDQQDPLKHNPVNNVDFAYNNNTSGPPTPSPSDQVEAIQPTLPPVDLQDISLQTTRGNSTEEGETAESSLPNQVCHSSNDSPALENIADANQIEETELRSTADVDTKDESIDAEMLMKKEGALSLLSLSAAIYNTTLCEMGHGPQATALLSSSTESTQSSFDSESELVLEHRTSGKSIPQVEDIQLRLLQDQQRREQNKRGHCGVCAPCQCKVNCGECRSCLNQKTDHQICRLRRCIKLRKKTLIICTGKVESEANSVNGTSSEQMEETCAAPEEEAHYIPVTHNVPPDIITPLQHGLLPEPHGKDPGTTDVLLPHSFSSTSHNGAEHIKSNAQRYVDPTETPANFHSSTINNRHAPEVVQEQMVPLKKIKLEEQQLEIDDQHSKHLETNGCYEDALSTLAAVVCFSSTDRKSLEEKLFGSQTSDVCLKTEPKEEPYQCQLNQEEPPQNDYIALSLPTVQSLVQHRNISVDQAIAIEALTQLAAIPQTVPFKTENQIQDAQQETSTYSAPSNHIPIREAKPATDVVSNKVSVISSSLHQTSVIRSSLNTPTNFTQSQRCAPPPRKLSLKDLLMASSECEKLSYTTENRRNGQALCKSDRLEGTFKMYRHGEATPIYRKKDEEEVAAQLVQLAFMIESRQAQVSENSPPNGMATQSLKYNQNYLGQHLKKQRKPKMTPSNPRMSKKKVAEIDDNHCRILLAKKTPNKKTPLKATIQKAISQHKMRFQHKRNPFLPQAQIDLKKYIAEAQHENRQLLYYNTKKEHLETFIGSGRQNGFHVKYEHGGHSLPPQNGHFYNHTNDHLGASQCPRHECEQKVSQVSKTYDVLNPGAKQQLLQTMANEPFKDLPQIPEMYHKANGFNGHQHLHTNQNGFYKVEKSGGVTVLSASSVHSENGDMVYAGEQTPTKHTINSFLESPMRFLDTPTRNLINTPSKQSMEIPSCDCVEHIIEKEEGPYYTHLGSGPNVAAVREMMETRYGEKGNAVRVEVVVYTGKEGRSSQGCPIAKWIIRRGSEQEKLLCLVRQRAGHCCQNAVIVILILAWEGIPRSVADRLYQELTQTLCKYGSPTSRRCALNEDRTCACQGLDPETCGASFSFGCSWSMYFNGCKFARSKTPRKFRLQGDSPKEEGRLEKNLQNLASDLAPVYKRLAPKAFHNQVEQEQRGQDCRLGCREGRPFSGVTACVDFCAHAHKDTHNMTNGSTVVCTLTKEDNRAVRNIPEDEQLHVLPLYKISDTDEFGKVEGQWAKIKTGALQVLSAFPREVRLLAEPVKSAHKRRLEAKRAHVEKLNSLGSKQVTPVKMKNESPKGFKQTSTENSSFSEKNSPNLSSTMRVPDIGGQYSPLHSGGSYNQSNSCRTPPVGSSFGTSTLPKFPHDPSGGTTHFNGSPPFRHGTIKQEPFRNDPVRTNPKFKSEPEEMRCFQGGAAPTPLSPPMAEGLHSRLNITAQPVTPEVAKAEEVWSDSEHNFLDKNIGGVAVAPSHGSILIECARRELHATTPILRPDRTHPTRISLVFYQHKSLNAPGHGLQQWEAKRAEKAREKEQAERLGLNNQSEPVDSDTDSENETCLDERHKFQVPTRQSLTVSRDSLVMSAPYALTHVTGPYNRWT

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8M9Q186A0A8M9Q186_DANREtet11812
A0A8M3AZ15A0A8M3AZ15_DANREtet11370

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias158-180Basic and acidic residues
Compositional bias746-761Polar residues
Compositional bias1540-1583Polar residues
Compositional bias1591-1635Polar residues
Compositional bias1643-1662Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX927098
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KC689999
EMBL· GenBank· DDBJ
AHE93329.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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