F1R3C6 · F1R3C6_DANRE
- ProteinMethylcytosine dioxygenase TET
- Genetet1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1855 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Catalytic activity
- 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H+ + succinate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe2+ ion per subunit.
Note: The zinc ions have a structural role.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | nucleus | |
Molecular Function | 5-methylcytosine dioxygenase activity | |
Molecular Function | DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | 5-methylcytosine catabolic process | |
Biological Process | cellular response to lipopolysaccharide | |
Biological Process | chromosomal 5-methylcytosine DNA demethylation pathway | |
Biological Process | epigenetic regulation of gene expression | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | regulation of interleukin-13 production | |
Biological Process | response to hypoxia |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethylcytosine dioxygenase TET
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionF1R3C6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 32-60 | Disordered | ||||
Sequence: QTPPPSPSLTSAMPRTAKAPKKSTRASTK | ||||||
Region | 81-107 | Disordered | ||||
Sequence: ASGEIKKGIDKKQAAKRAQRTVVSKPN | ||||||
Region | 132-213 | Disordered | ||||
Sequence: LLLECNGKGKSPRKSVSCPSIQRDVQKKGAQEIREQETETKRSEVNDPNGDAEQQKGAEIPTGEGQSVNISSKESGEEHRET | ||||||
Compositional bias | 158-180 | Basic and acidic residues | ||||
Sequence: KKGAQEIREQETETKRSEVNDPN | ||||||
Region | 267-286 | Disordered | ||||
Sequence: AYNNNTSGPPTPSPSDQVEA | ||||||
Region | 304-331 | Disordered | ||||
Sequence: TRGNSTEEGETAESSLPNQVCHSSNDSP | ||||||
Domain | 445-486 | CXXC-type | ||||
Sequence: EQNKRGHCGVCAPCQCKVNCGECRSCLNQKTDHQICRLRRCI | ||||||
Compositional bias | 746-761 | Polar residues | ||||
Sequence: IQDAQQETSTYSAPSN | ||||||
Region | 746-765 | Disordered | ||||
Sequence: IQDAQQETSTYSAPSNHIPI | ||||||
Compositional bias | 1540-1583 | Polar residues | ||||
Sequence: GSKQVTPVKMKNESPKGFKQTSTENSSFSEKNSPNLSSTMRVPD | ||||||
Region | 1540-1662 | Disordered | ||||
Sequence: GSKQVTPVKMKNESPKGFKQTSTENSSFSEKNSPNLSSTMRVPDIGGQYSPLHSGGSYNQSNSCRTPPVGSSFGTSTLPKFPHDPSGGTTHFNGSPPFRHGTIKQEPFRNDPVRTNPKFKSEP | ||||||
Compositional bias | 1591-1635 | Polar residues | ||||
Sequence: LHSGGSYNQSNSCRTPPVGSSFGTSTLPKFPHDPSGGTTHFNGSP | ||||||
Compositional bias | 1643-1662 | Basic and acidic residues | ||||
Sequence: KQEPFRNDPVRTNPKFKSEP | ||||||
Region | 1784-1817 | Disordered | ||||
Sequence: KAREKEQAERLGLNNQSEPVDSDTDSENETCLDE |
Sequence similarities
Belongs to the TET family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,855
- Mass (Da)206,332
- Last updated2011-05-03 v1
- Checksum5941B66D32A9D706
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9Q186 | A0A8M9Q186_DANRE | tet1 | 1812 | ||
A0A8M3AZ15 | A0A8M3AZ15_DANRE | tet1 | 1370 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 158-180 | Basic and acidic residues | ||||
Sequence: KKGAQEIREQETETKRSEVNDPN | ||||||
Compositional bias | 746-761 | Polar residues | ||||
Sequence: IQDAQQETSTYSAPSN | ||||||
Compositional bias | 1540-1583 | Polar residues | ||||
Sequence: GSKQVTPVKMKNESPKGFKQTSTENSSFSEKNSPNLSSTMRVPD | ||||||
Compositional bias | 1591-1635 | Polar residues | ||||
Sequence: LHSGGSYNQSNSCRTPPVGSSFGTSTLPKFPHDPSGGTTHFNGSP | ||||||
Compositional bias | 1643-1662 | Basic and acidic residues | ||||
Sequence: KQEPFRNDPVRTNPKFKSEP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX927098 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KC689999 EMBL· GenBank· DDBJ | AHE93329.1 EMBL· GenBank· DDBJ | mRNA |