F1QYC7 · F1QYC7_DANRE
- Protein3-hydroxyanthranilate 3,4-dioxygenase
- Genehaao
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids287 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.
Catalytic activity
- 3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde
Cofactor
Pathway
Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from L-kynurenine: step 3/3.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 46 | O2 (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 50 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 56 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: E | ||||||
Binding site | 56 | substrate | ||||
Sequence: E | ||||||
Binding site | 94 | Fe cation (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 98 | substrate | ||||
Sequence: R | ||||||
Binding site | 108 | substrate | ||||
Sequence: E |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-hydroxyanthranilate 3,4-dioxygenase activity | |
Molecular Function | ferrous iron binding | |
Biological Process | 'de novo' NAD biosynthetic process from tryptophan | |
Biological Process | anthranilate metabolic process | |
Biological Process | quinolinate biosynthetic process | |
Biological Process | tryptophan catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name3-hydroxyanthranilate 3,4-dioxygenase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionF1QYC7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-219 | Domain A (catalytic) | ||||
Sequence: MTNQSLHVNIDKWIAENETSFLPPVCNKLMFFYQLNIMYVGGPNVRKDYHIEEGEELFYQVRGDMVLKVIENGKHKDVHIREGEMFLLPARIPHSPQRQANTVGLVVERRRLSKETDGLRYFVANSTEVLFERWFYCENLGTQLVPIIKEFLDSKENETGKPDPANPIKPAPYPLNTMNVMTPFSFREWVEKQKPVLASGCPVDMFGEQFETETLLFGS | ||||||
Region | 219-287 | Domain B | ||||
Sequence: SGTSANKRRTDGWIWQLEGLSNVFMNGKEYSLSAGDCLLIFGETEYKWQRSQDCVALYVAQDPDRKRPY |
Sequence similarities
Belongs to the 3-HAO family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length287
- Mass (Da)33,193
- Last updated2011-05-03 v1
- ChecksumD65CF54FB478959D
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q5U3F8 | 3HAO_DANRE | haao | 287 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CU570986 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |