F1QYC7 · F1QYC7_DANRE

Function

function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from L-kynurenine: step 3/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site46O2 (UniProtKB | ChEBI)
Binding site50Fe cation (UniProtKB | ChEBI); catalytic
Binding site56Fe cation (UniProtKB | ChEBI); catalytic
Binding site56substrate
Binding site94Fe cation (UniProtKB | ChEBI); catalytic
Binding site98substrate
Binding site108substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-hydroxyanthranilate 3,4-dioxygenase activity
Molecular Functionferrous iron binding
Biological Process'de novo' NAD biosynthetic process from tryptophan
Biological Processanthranilate metabolic process
Biological Processquinolinate biosynthetic process
Biological Processtryptophan catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-hydroxyanthranilate 3,4-dioxygenase
  • EC number
  • Alternative names
    • 3-hydroxyanthranilate oxygenase
      (3-HAO
      )
    • 3-hydroxyanthranilic acid dioxygenase
      (HAD
      )

Gene names

    • Name
      haao
    • Synonyms
      HAAO
      , zgc:103585

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    F1QYC7
  • Secondary accessions
    • A0A8M2B2W8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-219Domain A (catalytic)
Region219-287Domain B

Sequence similarities

Belongs to the 3-HAO family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    287
  • Mass (Da)
    33,193
  • Last updated
    2011-05-03 v1
  • Checksum
    D65CF54FB478959D
MTNQSLHVNIDKWIAENETSFLPPVCNKLMFFYQLNIMYVGGPNVRKDYHIEEGEELFYQVRGDMVLKVIENGKHKDVHIREGEMFLLPARIPHSPQRQANTVGLVVERRRLSKETDGLRYFVANSTEVLFERWFYCENLGTQLVPIIKEFLDSKENETGKPDPANPIKPAPYPLNTMNVMTPFSFREWVEKQKPVLASGCPVDMFGEQFETETLLFGSGTSANKRRTDGWIWQLEGLSNVFMNGKEYSLSAGDCLLIFGETEYKWQRSQDCVALYVAQDPDRKRPY

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q5U3F83HAO_DANREhaao287

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU570986
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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