Hexb deficient zebrafish (hexb(-/-) ) showed lysosomal abnormalities already early in development both in radial glia which are the neuronal and glial progenitors and in microglia. Additionally at 5 days postfertilization hexb(-/-) zebrafish showed reduced locomotor activity. Although specific oligosaccharides accumulate in the adult brain hexb(-/-) ) zebrafish are viable and apparently resistant to Hexb deficiency.
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