F1QU76 · F1QU76_DANRE

Function

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Lipid metabolism; bile acid biosynthesis.

Features

Showing features for binding site.

151250100150200250300350400450500
TypeIDPosition(s)Description
Binding site108substrate
Binding site296substrate
Binding site452Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functioncholesterol 7-alpha-monooxygenase activity
Molecular Functionheme binding
Molecular Functioniron ion binding
Molecular Functionsteroid hydroxylase activity
Biological Processbile acid biosynthetic process
Biological Processcellular response to glucose stimulus
Biological Processcholesterol catabolic process
Biological Processcholesterol homeostasis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cholesterol 7-alpha-monooxygenase
  • EC number

Gene names

    • Name
      cyp7a1
    • Synonyms
      cyp7a1a
      , zgc:63920

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    F1QU76
  • Secondary accessions
    • A0A8N7V041

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-25Helical

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the cytochrome P450 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    512
  • Mass (Da)
    58,784
  • Last updated
    2011-05-03 v1
  • Checksum
    A35638B5E6E2B649
MILTISFIWAIVVGLCCCLWLITGIRRRHPAEPPLENGWIPFLGCALQFGANPLEFLRSRQKKHGHIFTCKIAGQYVHFLCDPFSYHAVIRQGRHLDWKKFHFDASAKAFGHESMDPSQGYTTENLHQTFLKTLQGDALSSLIETMMENLQGTMLQSGMLKATTSEWQSDGIYAFCYKVMFEAGYLTLFGKELDGDQSIARQQAQKALVLNALDNFKEFDKIFPALIAGLPIHVFKSAYSAREKLAKTMLHENLSRRANVSDLISLRMLLNDTLSTFNELSKARTHVAILWASQANTLPATFWTLFHMIRCPAAMKAASEEVRRTFESSNQKVDPTNSRLVLTREQLDNMPVLDSIIKEAMRLSSASLNVRMAKSDFLLQLDNKESYHIRKDDVIAMYPPMIHFDPEIYDDPLEFKYDRYIDENGQEKTTFYRNGRKLRYYYMPFGSGVTKCPGRFFAVHEIKQFLSLLLSYFEMELLDSDVKEPPLDQSRAGLGVLQPTYDVDFRYRLKSL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR450692
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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