F1QU76 · F1QU76_DANRE
- ProteinCholesterol 7-alpha-monooxygenase
- Genecyp7a1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids512 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 7alpha-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H+
Cofactor
Pathway
Lipid metabolism; bile acid biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | cholesterol 7-alpha-monooxygenase activity | |
Molecular Function | heme binding | |
Molecular Function | iron ion binding | |
Molecular Function | steroid hydroxylase activity | |
Biological Process | bile acid biosynthetic process | |
Biological Process | cellular response to glucose stimulus | |
Biological Process | cholesterol catabolic process | |
Biological Process | cholesterol homeostasis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCholesterol 7-alpha-monooxygenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionF1QU76
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-25 | Helical | ||||
Sequence: SFIWAIVVGLCCCLWLITGI |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length512
- Mass (Da)58,784
- Last updated2011-05-03 v1
- ChecksumA35638B5E6E2B649
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR450692 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |