F1Q4W7 · F1Q4W7_DANRE

Function

function

Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.

Catalytic activity

Features

Showing features for binding site.

114542004006008001,0001,2001,400
TypeIDPosition(s)Description
Binding site486Zn2+ 1 (UniProtKB | ChEBI)
Binding site497Zn2+ 1 (UniProtKB | ChEBI)
Binding site510Zn2+ 2 (UniProtKB | ChEBI)
Binding site511Zn2+ 2 (UniProtKB | ChEBI)
Binding site514Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionhistone H3K79 methyltransferase activity
Molecular Functionhistone H3K79 trimethyltransferase activity
Molecular Functionmetal ion binding
Biological Processcanonical Wnt signaling pathway
Biological ProcessDNA damage checkpoint signaling
Biological ProcessDNA repair
Biological Processintestinal epithelial structure maintenance
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Histone-lysine N-methyltransferase, H3 lysine-79 specific
  • EC number
  • Alternative names
    • Histone H3-K79 methyltransferase

Gene names

    • Ordered locus names
      dot1l

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    F1Q4W7

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_501535581325-1454Histone-lysine N-methyltransferase, H3 lysine-79 specific
Disulfide bond527Interchain

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region, coiled coil.

TypeIDPosition(s)Description
Domain1-261DOT1
Compositional bias266-282Basic and acidic residues
Region266-356Disordered
Compositional bias288-308Basic and acidic residues
Compositional bias320-341Basic residues
Compositional bias342-356Basic and acidic residues
Coiled coil487-564
Region589-621Disordered
Region738-760Disordered
Region800-1009Disordered
Compositional bias802-841Polar residues
Compositional bias884-907Basic and acidic residues
Compositional bias909-931Polar residues
Compositional bias933-974Basic residues
Compositional bias995-1009Polar residues
Region1023-1199Disordered
Compositional bias1052-1083Polar residues
Compositional bias1084-1103Basic and acidic residues
Compositional bias1106-1132Polar residues
Compositional bias1158-1176Basic and acidic residues
Compositional bias1179-1199Polar residues
Compositional bias1309-1334Polar residues
Region1309-1454Disordered
Compositional bias1358-1374Pro residues
Compositional bias1375-1414Polar residues
Compositional bias1429-1454Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,454
  • Mass (Da)
    157,952
  • Last updated
    2018-06-20 v2
  • Checksum
    0ADB470976BDCDFE
MLLFLPRITCKIVCLCVVQWKGTTQPMKLNKRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQIIDEMEMMEEDTFVDLGSGVGQVVLQVAAATNCKHYYGVEKADIPATYAESMDKEFKRWMKWYGKKHGEYTLERGDFLSEEWKERIASTSVIFVNNFAFGPEVDHQLKERFANMKEGGKIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLRGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEVARRRPQKDSKENKSNTTTPTKPKEHKQAQHDSGGEEEPVVPVKPSPKPRRAKILTRGRKLGNRKRGRPKKAPAATAAERKNKKSQSALDLLHAKTLSAAPAQEPYRSPQSPFYQLPPKVQHYTSSQLLMAPTPPGLQTLLDNIKVQYLHFMAYMKTPQYRTNLQQSLEQEKLRHTELSSQAQQLVNACHAHKERIHDLFQSKLEELGVKAVTVEDLVQAQKEITAHNMQLREQTKQLEHDMAELRDQSQLLLKARCEELKLDTLCWDTLKKEIEALRRQISEKQRHCLELQISIVELEKSQRQQELLQLKSSYSPCEVSPYRKALPGPDPRPTLDPDTPKLTPQSSMGLNGLSPELSINGTASPGYERCTGSAMGKNELLTHYLPISPDHEIVPPTPDSRTRQLGQPLPDYTRFSPAKIALRRHLNQDSAANQFRALGNIHRGDTGAISSPTLGFKQASPCSSEVQAVTTAKSTDRADKEKSPTAPGDTITSLPISIPLSTVHPSKLPVSIPLASVVLPNRVERLRSTLSPVLNPAGQSNGKPPLTPTSGYSSSSGLVNGSHSTMLTEDQDCDVASPPPHSTPVMGLQPRGSGLSPPLGTGGVLQYADGPPRLPPEDGHERQGPESDTEPLDSEARRRIFFSSSSSSSSSSSSTGGSRLHHGSVKQGHHHHSKHHHHHHHHHHHHSPSSHSQEGRKRGRRKRSSSGAVPMSGSPKRRVFPGLGCSSHSSGSPLNINSMVNNINQPLEISAISSPEQSGRSPCEQDLDQPPVLKRERPLELNNTGRYSSAPSSDEEGNGYAPDTSSSSRIERKIATISLDRDGPVRDLERGLQGRKSGASSVSSEVSSSSGTSKWKSTFSPISDPKPTPPDIRQGGSPFSVGASRGGTDSDSDHKPQRRGEREREPYGNSNLFLSQDGSGRSAVNTSERSLQKQKVREWDLKSVSGLASQNLFISAAASGGILSGKVGGAATVSSASAVGQYFPLGGASVLQPLFGTQAAGPATSGAPRLVNGHSALGSFSSAGLAGGAAGGIFHHMVSSSSSQQSGPNLPSSHNSQQRHLDTNPKAGASFLASGPNRTQTVLHAPSPPTLALPPPPPLLNTVPSQPSSPRSSRPQSSIPVATSSQSLAAASSSCTSSASSRPFTVHYPPHLQPPGSAGSGGTGASWRTLASYTASQIPGNRPR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias266-282Basic and acidic residues
Compositional bias288-308Basic and acidic residues
Compositional bias320-341Basic residues
Compositional bias342-356Basic and acidic residues
Compositional bias802-841Polar residues
Compositional bias884-907Basic and acidic residues
Compositional bias909-931Polar residues
Compositional bias933-974Basic residues
Compositional bias995-1009Polar residues
Compositional bias1052-1083Polar residues
Compositional bias1084-1103Basic and acidic residues
Compositional bias1106-1132Polar residues
Compositional bias1158-1176Basic and acidic residues
Compositional bias1179-1199Polar residues
Compositional bias1309-1334Polar residues
Compositional bias1358-1374Pro residues
Compositional bias1375-1414Polar residues
Compositional bias1429-1454Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL773593
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BX005098
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

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