F1NVK6 · TM237_CHICK
- ProteinTransmembrane protein 237
- GeneTMEM237
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids394 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Component of the transition zone in primary cilia. Required for ciliogenesis (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | ciliary transition zone | |
Cellular Component | membrane | |
Biological Process | cilium assembly | |
Biological Process | regulation of Wnt signaling pathway |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTransmembrane protein 237
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionF1NVK6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Note: Localizes to the transition zone.
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 213-233 | Helical | ||||
Sequence: VIGLFTHGFLAGYAVWNIVVI | ||||||
Transmembrane | 254-274 | Helical | ||||
Sequence: LAYPAQSLFYLLLSISTVSAF | ||||||
Transmembrane | 288-308 | Helical | ||||
Sequence: GFLTLDPAALASFLYFTALIL | ||||||
Transmembrane | 344-364 | Helical | ||||
Sequence: WIVVNLVVSILVGASWIFLSY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000415830 | 1-394 | Transmembrane protein 237 | |||
Sequence: MGKKQVCPPRALPPVPSFCSADDIPLSRPKKRKPKGKTPLDDIVQATVRRQSESSEPLTPEPQDVPPQRKRKKKKVPPDSETSFTQQNTASLFQNGNGVDVPEAEETVVRKQRKRTKKARPAETHSSNELEVEEDDIIEDEHRRSPDQQPVFAAPTGISQPVSKVFVEKNRRFQAADRAELIKTTENINVLLDVKSSWTTRDVALSVHRSFRVIGLFTHGFLAGYAVWNIVVIYILAGNQLTTVSNLLQQYKMLAYPAQSLFYLLLSISTVSAFDRIDLAKASVALRGFLTLDPAALASFLYFTALILSLSQQMTCDRINLYTPPSENGSIWTAGMEEEILQPWIVVNLVVSILVGASWIFLSYRPELDHSEELMFHTEIEEFPQDEREMLKSQ |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-135 | Disordered | ||||
Sequence: MGKKQVCPPRALPPVPSFCSADDIPLSRPKKRKPKGKTPLDDIVQATVRRQSESSEPLTPEPQDVPPQRKRKKKKVPPDSETSFTQQNTASLFQNGNGVDVPEAEETVVRKQRKRTKKARPAETHSSNELEVEED | ||||||
Compositional bias | 25-39 | Basic and acidic residues | ||||
Sequence: PLSRPKKRKPKGKTP | ||||||
Compositional bias | 45-59 | Polar residues | ||||
Sequence: QATVRRQSESSEPLT | ||||||
Compositional bias | 80-96 | Polar residues | ||||
Sequence: SETSFTQQNTASLFQNG |
Sequence similarities
Belongs to the TMEM237 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length394
- Mass (Da)44,406
- Last updated2012-02-22 v2
- ChecksumD73C9F788C72B2EA
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 25-39 | Basic and acidic residues | ||||
Sequence: PLSRPKKRKPKGKTP | ||||||
Compositional bias | 45-59 | Polar residues | ||||
Sequence: QATVRRQSESSEPLT | ||||||
Compositional bias | 80-96 | Polar residues | ||||
Sequence: SETSFTQQNTASLFQNG |
Keywords
- Technical term