F1NBT0 · STK10_CHICK
- ProteinSerine/threonine-protein kinase 10
- GeneSTK10
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids969 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
May act as a polo kinase kinase by mediating phosphorylation of PLK1.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | protein homodimerization activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | protein autophosphorylation | |
Biological Process | regulation of lymphocyte migration |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase 10
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Galloanserae > Galliformes > Phasianidae > Phasianinae > Gallus
Accessions
- Primary accessionF1NBT0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000414712 | 1-969 | Serine/threonine-protein kinase 10 | |||
Sequence: MAFANFRRILRLSTFEKRRSKEYEHVRRDLDPGEVWEVVGELGDGAFGKVYKAKNKETGALAAAKVIETKNEDELEDYMVEIEILATCDHPHIVKLLGAFYWEGKLWIMIEFCPGGAVDATMLELDRGLTEPQIQVICRQMLEALHYLHSKKIIHRDLKAGNVLLTQDGDIKLADFGVSAKNVKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLSCPSKWSLEFRDFLKTALDKNPETRPSAAQLLEHPFVSKVTSNRALRELVAEAKAEVLEEIEDSRDEAEDDDSSESASLPGKHKRDPSEVSQLSFDGDKPPDSSSLKTTNGPVATEKEMVNGQSDKVLDERISSDSDKLVNSHSTKTLASSGPDEGKATPGKPDIISLSGRRGSSAEGDKQPMPGSKERRSMVDRPESSHLENFPEEKLANGSLDSSAVFPGSRSKGDSDSGSTSASESMDLTISLSADLSLNRESGSISLKDSRMHNKTLKRTRKFVVDGVEVSVTTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQAQLNSKHQLQLDQMLRRFEQEMTAKKKFYDTELENLERQQKQQIEKMEQDHSLRRREEAKRIRLEQERDHVKFMEQLKQKKKEVKNEVEKLPRQQRKENMKVKMDDFAQRKQTMEQDFLAKQKEDLELAMKNITAQNKKEICDKERECLNKKQQLMRDREACIWDLEERQQQEKHQLIKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKIRQQQEKARLPKIQRSEGKTRMAMYKKSLHIHSSGSAAEQREKIKQFSQQEEKRQKAERLHQQQKHETQMKDMLAQCESNTNELQQLQNEKCHLLIEHETQKLKSLDENHNLHMKEWRDKLRPRKKALEDELNQKKREQEMFFKLSVEADEQTPASPVKHTKFIPFSSTESS |
Post-translational modification
Autophosphorylates.
Keywords
- PTM
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-294 | Protein kinase | ||||
Sequence: WEVVGELGDGAFGKVYKAKNKETGALAAAKVIETKNEDELEDYMVEIEILATCDHPHIVKLLGAFYWEGKLWIMIEFCPGGAVDATMLELDRGLTEPQIQVICRQMLEALHYLHSKKIIHRDLKAGNVLLTQDGDIKLADFGVSAKNVKTLQKRDSFIGTPYWMAPEVVMCETMKDTPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLSCPSKWSLEFRDFLKTALDKNPETRPSAAQLLEHPFV | ||||||
Region | 317-497 | Disordered | ||||
Sequence: EIEDSRDEAEDDDSSESASLPGKHKRDPSEVSQLSFDGDKPPDSSSLKTTNGPVATEKEMVNGQSDKVLDERISSDSDKLVNSHSTKTLASSGPDEGKATPGKPDIISLSGRRGSSAEGDKQPMPGSKERRSMVDRPESSHLENFPEEKLANGSLDSSAVFPGSRSKGDSDSGSTSASESM | ||||||
Compositional bias | 332-349 | Basic and acidic residues | ||||
Sequence: ESASLPGKHKRDPSEVSQ | ||||||
Compositional bias | 354-374 | Polar residues | ||||
Sequence: GDKPPDSSSLKTTNGPVATEK | ||||||
Compositional bias | 379-394 | Basic and acidic residues | ||||
Sequence: GQSDKVLDERISSDSD | ||||||
Compositional bias | 395-409 | Polar residues | ||||
Sequence: KLVNSHSTKTLASSG | ||||||
Compositional bias | 439-461 | Basic and acidic residues | ||||
Sequence: PMPGSKERRSMVDRPESSHLENF | ||||||
Compositional bias | 473-497 | Polar residues | ||||
Sequence: SSAVFPGSRSKGDSDSGSTSASESM | ||||||
Coiled coil | 574-698 | |||||
Sequence: QKEEHRNQAQLNSKHQLQLDQMLRRFEQEMTAKKKFYDTELENLERQQKQQIEKMEQDHSLRRREEAKRIRLEQERDHVKFMEQLKQKKKEVKNEVEKLPRQQRKENMKVKMDDFAQRKQTMEQD | ||||||
Region | 828-863 | Disordered | ||||
Sequence: IHSSGSAAEQREKIKQFSQQEEKRQKAERLHQQQKH | ||||||
Compositional bias | 833-863 | Basic and acidic residues | ||||
Sequence: SAAEQREKIKQFSQQEEKRQKAERLHQQQKH | ||||||
Coiled coil | 839-919 | |||||
Sequence: EKIKQFSQQEEKRQKAERLHQQQKHETQMKDMLAQCESNTNELQQLQNEKCHLLIEHETQKLKSLDENHNLHMKEWRDKLR | ||||||
Region | 947-969 | Disordered | ||||
Sequence: DEQTPASPVKHTKFIPFSSTESS |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length969
- Mass (Da)112,504
- Last updated2011-12-14 v2
- ChecksumE6BCE5C577063A8E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 332-349 | Basic and acidic residues | ||||
Sequence: ESASLPGKHKRDPSEVSQ | ||||||
Compositional bias | 354-374 | Polar residues | ||||
Sequence: GDKPPDSSSLKTTNGPVATEK | ||||||
Compositional bias | 379-394 | Basic and acidic residues | ||||
Sequence: GQSDKVLDERISSDSD | ||||||
Compositional bias | 395-409 | Polar residues | ||||
Sequence: KLVNSHSTKTLASSG | ||||||
Compositional bias | 439-461 | Basic and acidic residues | ||||
Sequence: PMPGSKERRSMVDRPESSHLENF | ||||||
Compositional bias | 473-497 | Polar residues | ||||
Sequence: SSAVFPGSRSKGDSDSGSTSASESM | ||||||
Compositional bias | 833-863 | Basic and acidic residues | ||||
Sequence: SAAEQREKIKQFSQQEEKRQKAERLHQQQKH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AADN02028926 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02028927 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02028928 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02028929 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02028930 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02028931 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02028932 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02028933 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AADN02028934 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |