F1N1E3 · F1N1E3_BOVIN
- ProteinMatrix metalloproteinase-14
- GeneMMP14
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids746 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.
Cofactor
Protein has several cofactor binding sites:
Note: Can bind about 5 Ca2+ ions per subunit.
Note: Binds 2 Zn2+ ions per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 256 | Zn2+ 2 (UniProtKB | ChEBI); catalytic; in inhibited form | |||
Binding site | 339 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 349 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 351 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 356 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 357 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 364 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 371 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 373 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 375 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 377 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 379 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 382 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 382 | Ca2+ 3 (UniProtKB | ChEBI) | |||
Binding site | 402 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | |||
Active site | 403 | ||||
Binding site | 406 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 412 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 420 | Zn2+ 2 (UniProtKB | ChEBI); catalytic | |||
Binding site | 487 | Ca2+ 4 (UniProtKB | ChEBI) | |||
Binding site | 534 | Ca2+ 5 (UniProtKB | ChEBI) | |||
Binding site | 581 | Ca2+ 5 (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMatrix metalloproteinase-14
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionF1N1E3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 703-726 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Modified residue | 562 | Phosphotyrosine; by PKDCC | |||
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, motif, domain, repeat.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-31 | Disordered | |||
Region | 63-118 | Disordered | |||
Region | 134-168 | Disordered | |||
Motif | 254-270 | Cysteine switch | |||
Domain | 278-448 | Peptidase metallopeptidase | |||
Region | 443-479 | Disordered | |||
Repeat | 479-527 | Hemopexin | |||
Repeat | 528-573 | Hemopexin | |||
Repeat | 575-623 | Hemopexin | |||
Repeat | 624-671 | Hemopexin | |||
Sequence similarities
Belongs to the peptidase M10A family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length746
- Mass (Da)83,721
- Last updated2024-05-29 v3
- Checksum936023302AABCF2C
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9SGZ3 | A0AAA9SGZ3_BOVIN | MMP14 | 503 | ||
A0AAA9TY69 | A0AAA9TY69_BOVIN | MMP14 | 567 |
Keywords
- Technical term