F1MV74 · F1MV74_BOVIN

  • Protein
    Sterol carrier protein 2
  • Gene
    SCP2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    5/5

Function

function

Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.
Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.

Catalytic activity

  • 3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoA
    This reaction proceeds in the forward direction.
  • 3-oxohexadecanedioyl-CoA + CoA = tetradecanedioyl-CoA + acetyl-CoA
    This reaction proceeds in the forward direction.
  • 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
    EC:2.3.1.176 (UniProtKB | ENZYME | Rhea)
  • 7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)
  • an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA
    This reaction proceeds in the backward direction.
    EC:2.3.1.16 (UniProtKB | ENZYME | Rhea)
  • butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
  • decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
  • dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
  • hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
  • hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
  • octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
  • tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA
    This reaction proceeds in the backward direction.
    EC:2.3.1.155 (UniProtKB | ENZYME | Rhea)
  • choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA
    This reaction proceeds in the backward direction.
    EC:2.3.1.176 (UniProtKB | ENZYME | Rhea)
  • propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoA
    This reaction proceeds in the backward direction.

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentperoxisome
Molecular Functionacetyl-CoA C-acyltransferase activity
Molecular Functionacetyl-CoA C-myristoyltransferase activity
Molecular Functionlipid binding
Molecular Functionpropanoyl-CoA C-acyltransferase activity
Molecular Functionpropionyl-CoA C2-trimethyltridecanoyltransferase activity
Biological Processintracellular cholesterol transport
Biological Processphospholipid transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sterol carrier protein 2
  • EC number
  • Alternative names
    • Acetyl-CoA C-myristoyltransferase
    • Non-specific lipid-transfer protein
    • Propanoyl-CoA C-acyltransferase
    • SCP-2/3-oxoacyl-CoA thiolase
    • SCP-2/thiolase

Gene names

    • Name
      SCP2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Hereford
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

  • Primary accession
    F1MV74

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Expression

Gene expression databases

Interaction

Subunit

Interacts with PEX5; the interaction is essential for peroxisomal import.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain14-238Thiolase N-terminal
Domain277-393Thiolase C-terminal
Domain433-534SCP2

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    543
  • Mass (Da)
    58,593
  • Last updated
    2011-05-03 v1
  • Checksum
    4DF70541303A58DF
MSLVASQSPLRNRVFVVGVGMTKFTKPGVENRDYPDLAKEAGQKALADAQIPYSAVEQACIGYVYGDSTSGQRAIYHSLGLTGIPIINVNNNCSTGSTALFMARQLIQGGLADCVLALGFEKMEKGPIAVNIQDKANPIDKHVEVMVNKYGLSPSPVAPQMFGNAGKEHMEKYGTTLEHFAKIGWKNHKHSVNNPYSQFQKEYSLDEVMTSRKIFDFLTVLQCCPTSDGAAAAILASEAFVQKHNLKPKAVEILAQEMVTDMPSSFEGKSIIKMVGFDMSKEAARRCYEKSGLRPSDIDVIELHDCFSANELITYEALGLCPEGQGGKLVERGDNTYGGKWVINPSGGLISKGHPLGATGLAQCVELCWHLRGEAGKRQVPGAKVALQHNIGIGGAVVVTLYKMGFPEAARTHQIEAAPTSSSVDGFKANLVFKEIEKKLEDEGEQFVKKIGGIFAFKVKDGPGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDLLALMTGKMNPQTAFFQGKLKINGNMGLAMKLQNLQLQPGKAKL

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0AAA9SI14A0AAA9SI14_BOVINSCP2494
A0AAA9TLA7A0AAA9TLA7_BOVINSCP2554
A0AAA9S3B8A0AAA9S3B8_BOVINSCP2521
A0AAA9RY23A0AAA9RY23_BOVINSCP2514
A0AAA9RZW0A0AAA9RZW0_BOVINSCP2545
A0AAA9SDZ8A0AAA9SDZ8_BOVINSCP2499

Keywords

Genome annotation databases

Similar Proteins

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