F1MV74 · F1MV74_BOVIN
- ProteinSterol carrier protein 2
- GeneSCP2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids543 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol. Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.
Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs.
Catalytic activity
- 3-oxo-(9Z-octadecenoyl)-CoA + CoA = (7Z)-hexadecenoyl-CoA + acetyl-CoAThis reaction proceeds in the forward direction.
- 3-oxohexadecanedioyl-CoA + CoA = tetradecanedioyl-CoA + acetyl-CoAThis reaction proceeds in the forward direction.
- 7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)
- butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoAThis reaction proceeds in the backward direction.
- decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoAThis reaction proceeds in the backward direction.
- dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoAThis reaction proceeds in the backward direction.
- hexadecanoyl-CoA + acetyl-CoA = 3-oxooctadecanoyl-CoA + CoAThis reaction proceeds in the backward direction.
- hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoAThis reaction proceeds in the backward direction.
- octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoAThis reaction proceeds in the backward direction.
- propanoyl-CoA + tetradecanoyl-CoA = 3-oxo-2-methylhexadecanoyl-CoA + CoAThis reaction proceeds in the backward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | peroxisome | |
Molecular Function | acetyl-CoA C-acyltransferase activity | |
Molecular Function | acetyl-CoA C-myristoyltransferase activity | |
Molecular Function | lipid binding | |
Molecular Function | propanoyl-CoA C-acyltransferase activity | |
Molecular Function | propionyl-CoA C2-trimethyltridecanoyltransferase activity | |
Biological Process | intracellular cholesterol transport | |
Biological Process | phospholipid transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSterol carrier protein 2
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos
Accessions
- Primary accessionF1MV74
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Interaction
Subunit
Interacts with PEX5; the interaction is essential for peroxisomal import.
Structure
Sequence
- Sequence statusComplete
- Length543
- Mass (Da)58,593
- Last updated2011-05-03 v1
- Checksum4DF70541303A58DF
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0AAA9SI14 | A0AAA9SI14_BOVIN | SCP2 | 494 | ||
A0AAA9TLA7 | A0AAA9TLA7_BOVIN | SCP2 | 554 | ||
A0AAA9S3B8 | A0AAA9S3B8_BOVIN | SCP2 | 521 | ||
A0AAA9RY23 | A0AAA9RY23_BOVIN | SCP2 | 514 | ||
A0AAA9RZW0 | A0AAA9RZW0_BOVIN | SCP2 | 545 | ||
A0AAA9SDZ8 | A0AAA9SDZ8_BOVIN | SCP2 | 499 |
Keywords
- Technical term