F1M5N7 · KI21B_RAT

  • Protein
    Kinesin-like protein KIF21B
  • Gene
    Kif21b
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.

Features

Showing features for binding site.

116342004006008001,0001,2001,4001,600
TypeIDPosition(s)Description
Binding site87-94ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentdendrite cytoplasm
Cellular Componentglutamatergic synapse
Cellular Componentgrowth cone
Cellular Componentkinesin complex
Cellular Componentmicrotubule
Cellular Componentpostsynaptic endosome
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionmicrotubule binding
Molecular Functionmicrotubule motor activity
Biological Processbrain development
Biological Processcorpus callosum development
Biological Processmicrotubule-based movement
Biological Processregulation of postsynaptic membrane neurotransmitter receptor levels
Biological Processretrograde dendritic transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Kinesin-like protein KIF21B

Gene names

    • Name
      Kif21b

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    F1M5N7

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004381491-1634Kinesin-like protein KIF21B
Modified residue580Phosphoserine
Modified residue583Phosphothreonine
Modified residue1145Phosphoserine
Modified residue1163Phosphoserine
Modified residue1212Phosphoserine
Modified residue1234Phosphothreonine
Modified residue1238Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in brain (at protein level).

Gene expression databases

Interaction

Subunit

Interacts with TRIM3; the interaction positively affects motility of KIF21B (By similarity).
Interacts with GABARAP and GABA(A) receptor subunits: GABRG2, GABRA1 and GABRA2 (PubMed:25172774).
May interact with GABA(A) receptor subunits: GABRB2 and GABRB3 (PubMed:25172774).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil, repeat.

TypeIDPosition(s)Description
Domain8-371Kinesin motor
Region401-1095Interaction with TRIM3
Region521-540Disordered
Compositional bias553-581Basic and acidic residues
Region553-624Disordered
Compositional bias582-619Acidic residues
Region832-861Disordered
Compositional bias843-861Polar residues
Coiled coil924-1012
Compositional bias1194-1214Polar residues
Region1194-1248Disordered
Repeat1303-1340WD 1
Repeat1343-1381WD 2
Repeat1407-1445WD 3
Repeat1448-1490WD 4
Repeat1499-1536WD 5
Repeat1540-1579WD 6
Repeat1582-1619WD 7

Sequence similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,634
  • Mass (Da)
    182,563
  • Last updated
    2013-04-03 v2
  • Checksum
    49DAB21E278F0044
MAGQGDCCVKVAVRIRPQLSKEKIEGCHICTSVTPGEPQVLLGKDKAFTYDFVFDLDTWQEQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDTVTSEEEQGIIPRAIAHLFRGIDERKRRAQEQGVTGPEFKVSAQFLELYNEEILDLFDSTRDPDARHRRSNIKIHEDANGGIYTTGVTSRLINSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRVCAQPDLVNETVTGLPDGTAPTGTEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQISALRAEIARLQMELMEYKAGKRVIGEDGAEGYSDLFRENAMLQKENGALRLRVKAMQEAIDAINNRVTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSRASARNPYSLGASPAGPAFGGSPASSMEDASEVIRRAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQQENSEETDENEAEEEEEERDESGCEEEEDEDSGSEESLVDSDSDPEEKEVNFQADLADLTCEIEIKQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQLERDRVLQNLSTMECYTEEKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYERELKKLQTEVAEMKKAKVALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQIRALESQKRQQEIVLRRKTQEVSALRRLAKPMSERVAGRVGLKPPNMDSGAEVSASTTSSEAESGARSVSSIVRQWNRKINHFLGDHPTATVNGARPARKKFQKKGASQSFSKAARLKWQSLERRIIDIVMQRMTIVNLEADMERLIKKREELFLLQEALRRKRERLQAESPEEEKGLQELAEEIEVLAANIDYINDSITDCQATIMQLEETKEELDSTDTSVVISSCSLAEARLLLDNFLKASIDKGLQVAQKEAQIRLLEGRLRQTDMTGSSQNHLLLDALREKAEAHPELQALIYNVQHENGYASTDEEVSEFSEGSFSQSFTMKGSTSHDDFKFKGEPKLSAQMKAVSAECLGPPLDSSTKNITKSLASLVEIKEDGVGFSIRDPYYRDKVSRTVSLPTRGSTFPRQSRGATDTSPLTRRKSYDRGQPIRSTDIGFTPPSSPPTRPRNDRNVFSRLTSNQSQGSALDKSDDSDSSLSEVLRGIITPIGGAKGARTAPLQCVSMAEGHTKPILCLDATDELLFTGSKDRSCKMWNLVTGQEIAALKGHPNNVVSIKYCSHSGLVFSVSSSYVKVWDIRDSAKCIRTLTSSGQVISGDACMATSTRAITSSQGEHQINQMALSPSGTMLYVASGNAVRIWELNRFQPIGKLTGHIGPVMCLTVTQTSNQHDLVVTGSKDHYVKMFQLGDCVTGTIGPTHNFEPPHYDGIECLAIQGDILFSGSRDNGIKKWDLDQQELIQQIPNAHKDWVCALAFVPGRPMLLSACRAGFIKVWNVDNFTPIGEIKGHDSPINAICTNSKHIFTASSDCRVKLWNYVPGLTPCLPRRVLAIKGRATTLP

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6AJU2A0A8I6AJU2_RATKif21b1542
A0A0G2K7Q9A0A0G2K7Q9_RATKif21b1620
A0A8I6G960A0A8I6G960_RATKif21b1574

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias553-581Basic and acidic residues
Compositional bias582-619Acidic residues
Compositional bias843-861Polar residues
Compositional bias1194-1214Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AABR07021001
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AABR07021002
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH473958
EMBL· GenBank· DDBJ
EDM09667.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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