F1M5N7 · KI21B_RAT
- ProteinKinesin-like protein KIF21B
- GeneKif21b
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1634 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plus-end directed microtubule-dependent motor protein which displays processive activity. Is involved in regulation of microtubule dynamics, synapse function and neuronal morphology, including dendritic tree branching and spine formation. Plays a role in lerning and memory. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptor to cell surface.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | dendrite cytoplasm | |
Cellular Component | glutamatergic synapse | |
Cellular Component | growth cone | |
Cellular Component | kinesin complex | |
Cellular Component | microtubule | |
Cellular Component | postsynaptic endosome | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | microtubule binding | |
Molecular Function | microtubule motor activity | |
Biological Process | brain development | |
Biological Process | corpus callosum development | |
Biological Process | microtubule-based movement | |
Biological Process | regulation of postsynaptic membrane neurotransmitter receptor levels | |
Biological Process | retrograde dendritic transport |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKinesin-like protein KIF21B
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionF1M5N7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000438149 | 1-1634 | Kinesin-like protein KIF21B | |||
Sequence: MAGQGDCCVKVAVRIRPQLSKEKIEGCHICTSVTPGEPQVLLGKDKAFTYDFVFDLDTWQEQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDTVTSEEEQGIIPRAIAHLFRGIDERKRRAQEQGVTGPEFKVSAQFLELYNEEILDLFDSTRDPDARHRRSNIKIHEDANGGIYTTGVTSRLINSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRVCAQPDLVNETVTGLPDGTAPTGTEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQISALRAEIARLQMELMEYKAGKRVIGEDGAEGYSDLFRENAMLQKENGALRLRVKAMQEAIDAINNRVTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSRASARNPYSLGASPAGPAFGGSPASSMEDASEVIRRAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQQENSEETDENEAEEEEEERDESGCEEEEDEDSGSEESLVDSDSDPEEKEVNFQADLADLTCEIEIKQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQLERDRVLQNLSTMECYTEEKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYERELKKLQTEVAEMKKAKVALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQIRALESQKRQQEIVLRRKTQEVSALRRLAKPMSERVAGRVGLKPPNMDSGAEVSASTTSSEAESGARSVSSIVRQWNRKINHFLGDHPTATVNGARPARKKFQKKGASQSFSKAARLKWQSLERRIIDIVMQRMTIVNLEADMERLIKKREELFLLQEALRRKRERLQAESPEEEKGLQELAEEIEVLAANIDYINDSITDCQATIMQLEETKEELDSTDTSVVISSCSLAEARLLLDNFLKASIDKGLQVAQKEAQIRLLEGRLRQTDMTGSSQNHLLLDALREKAEAHPELQALIYNVQHENGYASTDEEVSEFSEGSFSQSFTMKGSTSHDDFKFKGEPKLSAQMKAVSAECLGPPLDSSTKNITKSLASLVEIKEDGVGFSIRDPYYRDKVSRTVSLPTRGSTFPRQSRGATDTSPLTRRKSYDRGQPIRSTDIGFTPPSSPPTRPRNDRNVFSRLTSNQSQGSALDKSDDSDSSLSEVLRGIITPIGGAKGARTAPLQCVSMAEGHTKPILCLDATDELLFTGSKDRSCKMWNLVTGQEIAALKGHPNNVVSIKYCSHSGLVFSVSSSYVKVWDIRDSAKCIRTLTSSGQVISGDACMATSTRAITSSQGEHQINQMALSPSGTMLYVASGNAVRIWELNRFQPIGKLTGHIGPVMCLTVTQTSNQHDLVVTGSKDHYVKMFQLGDCVTGTIGPTHNFEPPHYDGIECLAIQGDILFSGSRDNGIKKWDLDQQELIQQIPNAHKDWVCALAFVPGRPMLLSACRAGFIKVWNVDNFTPIGEIKGHDSPINAICTNSKHIFTASSDCRVKLWNYVPGLTPCLPRRVLAIKGRATTLP | ||||||
Modified residue | 580 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 583 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1145 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1163 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1212 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 1234 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 1238 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in brain (at protein level).
Gene expression databases
Interaction
Subunit
Interacts with TRIM3; the interaction positively affects motility of KIF21B (By similarity).
Interacts with GABARAP and GABA(A) receptor subunits: GABRG2, GABRA1 and GABRA2 (PubMed:25172774).
May interact with GABA(A) receptor subunits: GABRB2 and GABRB3 (PubMed:25172774).
Interacts with GABARAP and GABA(A) receptor subunits: GABRG2, GABRA1 and GABRA2 (PubMed:25172774).
May interact with GABA(A) receptor subunits: GABRB2 and GABRB3 (PubMed:25172774).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 8-371 | Kinesin motor | ||||
Sequence: CVKVAVRIRPQLSKEKIEGCHICTSVTPGEPQVLLGKDKAFTYDFVFDLDTWQEQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDTVTSEEEQGIIPRAIAHLFRGIDERKRRAQEQGVTGPEFKVSAQFLELYNEEILDLFDSTRDPDARHRRSNIKIHEDANGGIYTTGVTSRLINSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRVCAQPDLVNETVTGLPDGTAPTGTEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQSKKVVHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNI | ||||||
Region | 401-1095 | Interaction with TRIM3 | ||||
Sequence: MEYKAGKRVIGEDGAEGYSDLFRENAMLQKENGALRLRVKAMQEAIDAINNRVTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIEELRTKLLESEAMNESLRRSLSRASARNPYSLGASPAGPAFGGSPASSMEDASEVIRRAKQDLERLKKKEVRQRRKSPEKEAFKKRAKLQQENSEETDENEAEEEEEERDESGCEEEEDEDSGSEESLVDSDSDPEEKEVNFQADLADLTCEIEIKQKLIDELENSQRRLQTLKHQYEEKLILLQNKIRDTQLERDRVLQNLSTMECYTEEKANKIKADYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYERELKKLQTEVAEMKKAKVALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQIRALESQKRQQEIVLRRKTQEVSALRRLAKPMSERVAGRVGLKPPNMDSGAEVSASTTSSEAESGARSVSSIVRQWNRKINHFLGDHPTATVNGARPARKKFQKKGASQSFSKAARLKWQSLERRIIDIVMQRMTIVNLEADMERLIKKREELFLLQEALRRKRERLQAESPEEEKGLQELAEEIEVLAANIDYINDSITDCQATIMQLEETKEELDSTDTSVVISSCSLAEARLLLDNFLKASIDKGLQVAQKEAQIRLLEGRLRQTDMTGSSQNHLLLDALREKAEAHPELQALIYNVQH | ||||||
Region | 521-540 | Disordered | ||||
Sequence: SPAGPAFGGSPASSMEDASE | ||||||
Compositional bias | 553-581 | Basic and acidic residues | ||||
Sequence: KKKEVRQRRKSPEKEAFKKRAKLQQENSE | ||||||
Region | 553-624 | Disordered | ||||
Sequence: KKKEVRQRRKSPEKEAFKKRAKLQQENSEETDENEAEEEEEERDESGCEEEEDEDSGSEESLVDSDSDPEEK | ||||||
Compositional bias | 582-619 | Acidic residues | ||||
Sequence: ETDENEAEEEEEERDESGCEEEEDEDSGSEESLVDSDS | ||||||
Region | 832-861 | Disordered | ||||
Sequence: RVGLKPPNMDSGAEVSASTTSSEAESGARS | ||||||
Compositional bias | 843-861 | Polar residues | ||||
Sequence: GAEVSASTTSSEAESGARS | ||||||
Coiled coil | 924-1012 | |||||
Sequence: MQRMTIVNLEADMERLIKKREELFLLQEALRRKRERLQAESPEEEKGLQELAEEIEVLAANIDYINDSITDCQATIMQLEETKEELDST | ||||||
Compositional bias | 1194-1214 | Polar residues | ||||
Sequence: LPTRGSTFPRQSRGATDTSPL | ||||||
Region | 1194-1248 | Disordered | ||||
Sequence: LPTRGSTFPRQSRGATDTSPLTRRKSYDRGQPIRSTDIGFTPPSSPPTRPRNDRN | ||||||
Repeat | 1303-1340 | WD 1 | ||||
Sequence: GHTKPILCLDATDELLFTGSKDRSCKMWNLVTGQEIAA | ||||||
Repeat | 1343-1381 | WD 2 | ||||
Sequence: GHPNNVVSIKYCSHSGLVFSVSSSYVKVWDIRDSAKCIR | ||||||
Repeat | 1407-1445 | WD 3 | ||||
Sequence: QGEHQINQMALSPSGTMLYVASGNAVRIWELNRFQPIGK | ||||||
Repeat | 1448-1490 | WD 4 | ||||
Sequence: GHIGPVMCLTVTQTSNQHDLVVTGSKDHYVKMFQLGDCVTGTI | ||||||
Repeat | 1499-1536 | WD 5 | ||||
Sequence: PHYDGIECLAIQGDILFSGSRDNGIKKWDLDQQELIQQ | ||||||
Repeat | 1540-1579 | WD 6 | ||||
Sequence: AHKDWVCALAFVPGRPMLLSACRAGFIKVWNVDNFTPIGE | ||||||
Repeat | 1582-1619 | WD 7 | ||||
Sequence: GHDSPINAICTNSKHIFTASSDCRVKLWNYVPGLTPCL |
Sequence similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,634
- Mass (Da)182,563
- Last updated2013-04-03 v2
- Checksum49DAB21E278F0044
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6AJU2 | A0A8I6AJU2_RAT | Kif21b | 1542 | ||
A0A0G2K7Q9 | A0A0G2K7Q9_RAT | Kif21b | 1620 | ||
A0A8I6G960 | A0A8I6G960_RAT | Kif21b | 1574 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 553-581 | Basic and acidic residues | ||||
Sequence: KKKEVRQRRKSPEKEAFKKRAKLQQENSE | ||||||
Compositional bias | 582-619 | Acidic residues | ||||
Sequence: ETDENEAEEEEEERDESGCEEEEDEDSGSEESLVDSDS | ||||||
Compositional bias | 843-861 | Polar residues | ||||
Sequence: GAEVSASTTSSEAESGARS | ||||||
Compositional bias | 1194-1214 | Polar residues | ||||
Sequence: LPTRGSTFPRQSRGATDTSPL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR07021001 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AABR07021002 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH473958 EMBL· GenBank· DDBJ | EDM09667.1 EMBL· GenBank· DDBJ | Genomic DNA |