F1LT10 · F1LT10_RAT
- ProteinAfadin, adherens junction formation factor
- GeneAfdn
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1670 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score1/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell-cell junction | |
Biological Process | cell adhesion | |
Biological Process | signal transduction |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionF1LT10
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 39-133 | Ras-associating | ||||
Sequence: FHGVMRFYFQDKAAGNFATKCIRVSSTATTQDVIETLAEKFRPDMRMLSSPKYSLYEVHVSGERRLDIDEKPLVVQLNWNKDDREGRFVLKNEND | ||||||
Region | 129-196 | Disordered | ||||
Sequence: KNENDAIPAKKAQSNGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKEERPSQGDDSENS | ||||||
Compositional bias | 143-196 | Basic and acidic residues | ||||
Sequence: NGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKEERPSQGDDSENS | ||||||
Domain | 246-348 | Ras-associating | ||||
Sequence: SGGTLRIYADSLKPNIPYKTILLSTTDPADFAVAESLEKYGLEKENPKDYCIARVMLPPGAQHSDERGAKEIILDDDECPLQIFREWPSDKGILVFQLKRRPP | ||||||
Region | 356-377 | Disordered | ||||
Sequence: KKHVEGKPLKGKDRADGSGYGS | ||||||
Region | 539-595 | Disordered | ||||
Sequence: DIHSGTALPASRSTTRLDSDRVSSASSTAERGMVKPMIRLDQEQDYRRRESRTQDAA | ||||||
Compositional bias | 545-568 | Polar residues | ||||
Sequence: ALPASRSTTRLDSDRVSSASSTAE | ||||||
Compositional bias | 574-593 | Basic and acidic residues | ||||
Sequence: PMIRLDQEQDYRRRESRTQD | ||||||
Domain | 668-915 | Dilute | ||||
Sequence: NKMVSMMEGVIQEVDQVDQKQKNIAGALAFWMANASELLNFIKQDRDLSRITLDAQDVLAHLVQMAFKYLVHCLQSELNNYMPAFLDDPEENSLQRPKIDDVLHTLTGAMSLLRRCRVNAALTIQLFSQLFHFINMWLFNRLVTDPDSGLCSHYWGAIIRQQLGHIEAWAEKQGLELAADCHLSRIVQATTLLTMDKYVPDDIPNINSTCFKLNSLQLQALLQNYHCAPDEPFIPTDLIENVVAVAEN | ||||||
Domain | 1014-1100 | PDZ | ||||
Sequence: VITVTLKKQNGMGLSIVAAKGAGQDKLGIYVKSVVKGGAADVDGRLAAGDQLLSVDGRSLVGLSQERAAELMTRTSSVVTLEVAKQG | ||||||
Region | 1114-1230 | Disordered | ||||
Sequence: SPMMQRISDRRGSGKPRPKSEGFELYNNSAQNGSPESPQMPWTEYSEPKKLPGDDRLMKNRADHRSSPNVANQPPSPGGKSPYTSGTAAKITSVSTGNLCTEEQTPPPRPEAYPIPT | ||||||
Compositional bias | 1137-1154 | Polar residues | ||||
Sequence: ELYNNSAQNGSPESPQMP | ||||||
Compositional bias | 1161-1176 | Basic and acidic residues | ||||
Sequence: PKKLPGDDRLMKNRAD | ||||||
Compositional bias | 1178-1216 | Polar residues | ||||
Sequence: RSSPNVANQPPSPGGKSPYTSGTAAKITSVSTGNLCTEE | ||||||
Region | 1300-1533 | Disordered | ||||
Sequence: ESGMDRKCDSDMWINQSSSVESSTSSQEHLNHSSKSVTPASTLTKSGPGRWKTPAAVLPTPVAVSQPIRTDLPPPPPPPPAHYTSDFDGISMDLPLPPPPANQAAPQSAQVAAAERKKREEHQRWYEKEKARLEEERERKRREQERKLGQMRTQSLNPASFSPLATQAKPEKPSTLQRPQETVIRELQPQQQPRTIERRDLQYITISKEELSSGDSLSPDPWKRDAREKLEKQQ | ||||||
Compositional bias | 1310-1347 | Polar residues | ||||
Sequence: DMWINQSSSVESSTSSQEHLNHSSKSVTPASTLTKSGP | ||||||
Compositional bias | 1367-1382 | Pro residues | ||||
Sequence: IRTDLPPPPPPPPAHY | ||||||
Compositional bias | 1412-1448 | Basic and acidic residues | ||||
Sequence: AAERKKREEHQRWYEKEKARLEEERERKRREQERKLG | ||||||
Compositional bias | 1449-1497 | Polar residues | ||||
Sequence: QMRTQSLNPASFSPLATQAKPEKPSTLQRPQETVIRELQPQQQPRTIER | ||||||
Compositional bias | 1519-1533 | Basic and acidic residues | ||||
Sequence: DPWKRDAREKLEKQQ | ||||||
Region | 1574-1594 | Disordered | ||||
Sequence: RLQESKQKDEDDDEEEDDDVD | ||||||
Region | 1628-1670 | Disordered | ||||
Sequence: RRQQQLEEMRKREVEDRVRQEEDGRHQEEERVKRDAEEKVMVL |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,670
- Mass (Da)189,795
- Last updated2022-05-25 v4
- ChecksumD6A6EC60144EEF2A
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
O35889 | AFAD_RAT | Afdn | 1829 | ||
A0A8I6AL62 | A0A8I6AL62_RAT | Afdn | 1758 | ||
A0A8I5ZNL2 | A0A8I5ZNL2_RAT | Afdn | 1772 | ||
A0A8I5ZLU6 | A0A8I5ZLU6_RAT | Afdn | 1885 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 143-196 | Basic and acidic residues | ||||
Sequence: NGPEKQEKEGVIQNFKRTLSKKEKKEKKKREKEALRQASDKEERPSQGDDSENS | ||||||
Compositional bias | 545-568 | Polar residues | ||||
Sequence: ALPASRSTTRLDSDRVSSASSTAE | ||||||
Compositional bias | 574-593 | Basic and acidic residues | ||||
Sequence: PMIRLDQEQDYRRRESRTQD | ||||||
Compositional bias | 1137-1154 | Polar residues | ||||
Sequence: ELYNNSAQNGSPESPQMP | ||||||
Compositional bias | 1161-1176 | Basic and acidic residues | ||||
Sequence: PKKLPGDDRLMKNRAD | ||||||
Compositional bias | 1178-1216 | Polar residues | ||||
Sequence: RSSPNVANQPPSPGGKSPYTSGTAAKITSVSTGNLCTEE | ||||||
Compositional bias | 1310-1347 | Polar residues | ||||
Sequence: DMWINQSSSVESSTSSQEHLNHSSKSVTPASTLTKSGP | ||||||
Compositional bias | 1367-1382 | Pro residues | ||||
Sequence: IRTDLPPPPPPPPAHY | ||||||
Compositional bias | 1412-1448 | Basic and acidic residues | ||||
Sequence: AAERKKREEHQRWYEKEKARLEEERERKRREQERKLG | ||||||
Compositional bias | 1449-1497 | Polar residues | ||||
Sequence: QMRTQSLNPASFSPLATQAKPEKPSTLQRPQETVIRELQPQQQPRTIER | ||||||
Compositional bias | 1519-1533 | Basic and acidic residues | ||||
Sequence: DPWKRDAREKLEKQQ |
Keywords
- Technical term