F1LSG7 · F1LSG7_RAT

  • Protein
    Fibroblast growth factor receptor
  • Gene
    Fgfr2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

Catalytic activity

Features

Showing features for binding site, active site.

1841100200300400500600700800
TypeIDPosition(s)Description
Binding site507-513ATP (UniProtKB | ChEBI)
Binding site537ATP (UniProtKB | ChEBI)
Binding site585-587ATP (UniProtKB | ChEBI)
Binding site591ATP (UniProtKB | ChEBI)
Active site646Proton acceptor
Binding site650ATP (UniProtKB | ChEBI)
Binding site664ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell cortex
Cellular Componentcell surface
Cellular Componentcollagen-containing extracellular matrix
Cellular Componentcytoplasm
Cellular Componentexcitatory synapse
Cellular ComponentGolgi apparatus
Cellular Componentnucleus
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular FunctionATP binding
Molecular Functionfibroblast growth factor binding
Molecular Functionfibroblast growth factor receptor activity
Molecular Functionprotein homodimerization activity
Biological Processangiogenesis
Biological Processanimal organ morphogenesis
Biological Processaxonogenesis
Biological Processbone development
Biological Processbone mineralization
Biological Processbone morphogenesis
Biological Processbranch elongation involved in salivary gland morphogenesis
Biological Processbranching involved in labyrinthine layer morphogenesis
Biological Processbranching involved in prostate gland morphogenesis
Biological Processbranching involved in salivary gland morphogenesis
Biological Processbranching morphogenesis of a nerve
Biological Processbud elongation involved in lung branching
Biological Processcanonical Wnt signaling pathway
Biological Processcardiac muscle cell proliferation
Biological Processcell division
Biological Processcell fate commitment
Biological Processcell population proliferation
Biological Processcell-cell signaling
Biological Processcellular response to fibroblast growth factor stimulus
Biological Processcellular response to hypoxia
Biological Processcellular response to retinoic acid
Biological Processcellular response to transforming growth factor beta stimulus
Biological Processcoronal suture morphogenesis
Biological Processdigestive tract development
Biological Processembryonic cranial skeleton morphogenesis
Biological Processembryonic digestive tract morphogenesis
Biological Processembryonic organ development
Biological Processembryonic organ morphogenesis
Biological Processembryonic pattern specification
Biological Processendochondral bone growth
Biological Processendodermal digestive tract morphogenesis
Biological Processepidermis morphogenesis
Biological Processepithelial cell differentiation
Biological Processepithelial cell proliferation
Biological Processepithelial cell proliferation involved in salivary gland morphogenesis
Biological Processepithelial to mesenchymal transition
Biological Processepithelial tube branching involved in lung morphogenesis
Biological ProcessERK1 and ERK2 cascade
Biological Processfibroblast growth factor receptor apoptotic signaling pathway
Biological Processfibroblast growth factor receptor signaling pathway
Biological Processfibroblast growth factor receptor signaling pathway involved in hemopoiesis
Biological Processfibroblast growth factor receptor signaling pathway involved in mammary gland specification
Biological Processfibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell
Biological Processfibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
Biological Processfibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow
Biological Processgland morphogenesis
Biological Processhair follicle morphogenesis
Biological Processin utero embryonic development
Biological Processinner ear morphogenesis
Biological Processlacrimal gland development
Biological Processlateral sprouting from an epithelium
Biological Processlens fiber cell development
Biological Processlimb bud formation
Biological Processlung alveolus development
Biological Processlung development
Biological Processlung lobe morphogenesis
Biological Processlung-associated mesenchyme development
Biological Processmammary gland bud formation
Biological Processmembranous septum morphogenesis
Biological Processmesenchymal cell differentiation
Biological Processmesenchymal cell differentiation involved in lung development
Biological Processmesenchymal cell proliferation
Biological Processmesenchymal cell proliferation involved in lung development
Biological Processmesodermal cell differentiation
Biological Processmidbrain development
Biological Processmitotic nuclear division
Biological Processmorphogenesis of embryonic epithelium
Biological Processnegative regulation of epithelial cell proliferation
Biological Processnegative regulation of keratinocyte proliferation
Biological Processnegative regulation of mitotic nuclear division
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processneuromuscular junction development
Biological Processodontogenesis
Biological Processorbitofrontal cortex development
Biological Processorgan growth
Biological Processotic vesicle formation
Biological Processoutflow tract septum morphogenesis
Biological Processpositive regulation of canonical Wnt signaling pathway
Biological Processpositive regulation of cardiac muscle cell proliferation
Biological Processpositive regulation of cell cycle
Biological Processpositive regulation of cell division
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of epithelial cell proliferation
Biological Processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of mesenchymal cell proliferation
Biological Processpositive regulation of stem cell proliferation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of urothelial cell proliferation
Biological Processpositive regulation of vascular associated smooth muscle cell proliferation
Biological Processpositive regulation of Wnt signaling pathway
Biological Processpost-embryonic development
Biological Processprostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
Biological Processprostate epithelial cord elongation
Biological Processprostate gland morphogenesis
Biological Processpyramidal neuron development
Biological Processregulation of epithelial cell proliferation
Biological Processregulation of ERK1 and ERK2 cascade
Biological Processregulation of morphogenesis of a branching structure
Biological Processregulation of osteoblast proliferation
Biological Processregulation of smooth muscle cell differentiation
Biological Processregulation of smoothened signaling pathway
Biological Processreproductive structure development
Biological Processresponse to ethanol
Biological Processresponse to lipopolysaccharide
Biological Processsquamous basal epithelial stem cell differentiation involved in prostate gland acinus development
Biological Processstem cell differentiation
Biological Processstem cell proliferation
Biological Processsynaptic vesicle transport
Biological Processureteric bud development
Biological Processurothelial cell proliferation
Biological Processventricular cardiac muscle tissue morphogenesis
Biological Processventricular zone neuroblast division

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fibroblast growth factor receptor
  • EC number

Gene names

    • Name
      Fgfr2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    F1LSG7

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Golgi apparatus
Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-40Helical
Transmembrane395-417Helical

Keywords

PTM/Processing

Features

Showing features for disulfide bond, glycosylation.

TypeIDPosition(s)Description
Disulfide bond81↔126
Glycosylation102N-linked (GlcNAc...) asparagine
Glycosylation142N-linked (GlcNAc...) asparagine
Disulfide bond198↔250
Glycosylation247N-linked (GlcNAc...) asparagine
Glycosylation260N-linked (GlcNAc...) asparagine
Glycosylation284N-linked (GlcNAc...) asparagine
Disulfide bond297↔359
Glycosylation316N-linked (GlcNAc...) asparagine
Glycosylation337N-linked (GlcNAc...) asparagine
Glycosylation348N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain58-138Ig-like
Region148-169Disordered
Domain173-266Ig-like
Domain275-375Ig-like
Domain501-790Protein kinase

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    841
  • Mass (Da)
    94,171
  • Last updated
    2011-05-03 v1
  • Checksum
    E6022333E6E099A9
MGLPSTWRYGTGPGIGTVTMVSWGRFICLVLVTMATLSLARPSFSLVEDTTLEPEEPPTKYQISQPEACVVAPGESLELRCMLKDAAVISWTKDGVHLGPNNRTVLIGEYLQIKGATPRDSGLYACAAARTVDSETLYFMVNVTDAISSGDDEDDTDSSEDFVSENRSNQRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSPHRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEMDAGEYICKVSNYIGQANQSAWLTVLPKQQAPVREKEITASPDYLEIAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLTQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYDPCLPQYPHINGSVKT

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F1LN06F1LN06_RATFgfr2726
F1LNW0F1LNW0_RATFgfr2840
F1LRU8F1LRU8_RATFgfr2752

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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