F1LP90 · MINK1_RAT
- ProteinMisshapen-like kinase 1
- GeneMink1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1336 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking (PubMed:21048137).
Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (PubMed:21048137).
Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (By similarity).
Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity).
Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (By similarity).
Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons (PubMed:21048137).
Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates TANC1 upon stimulation by RAP2A, MBP and SMAD1 (By similarity).
Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1 (By similarity).
Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (By similarity).
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
Features
Showing features for binding site, active site.
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMisshapen-like kinase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionF1LP90
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000413198 | 1-1336 | Misshapen-like kinase 1 | |||
Sequence: MGDPAPARQSDFIFLVALRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFIRDQPTERQVRIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPGESTLRREFLRLQQENKSNSEALKQQQQLQQQQQRDPEAHIKHLLHQRQRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLNSQKQQQQQQQQQQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEERARMNKQQNSPLAKTKPSSAGPEPPIPQASPSPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQNSDPTSEGPGPSPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNTSSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPADFVLLKERTLDEAPKPPKKAMDYSSSSEEVESSEDEEEEGDGEPSEGSRDTPGGRSDGDTDSVSTMVVHDVEEVSGTQPSYGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPTENSQGQSPPTKDGGGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGGRLDQLQFDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIVFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW | ||||||
Modified residue | 324 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 326 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 502 | Omega-N-methylarginine | ||||
Sequence: R | ||||||
Modified residue | 510 | Omega-N-methylarginine | ||||
Sequence: R | ||||||
Modified residue | 643 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 703 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 756 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 765 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 781 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 782 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 786 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 895 | Phosphothreonine | ||||
Sequence: T |
Post-translational modification
Autophosphorylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
Increased expression from 18 dpc to adulthood seen in cortex and hippocampus (at protein level).
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 25-289 | Protein kinase | ||||
Sequence: FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGNDDQLWLVMEFCGAGSVTDLVKNTKGNALKEDCIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFTDFIDTCLIKTYLSRPPTEQLLKFPFI | ||||||
Compositional bias | 299-320 | Basic and acidic residues | ||||
Sequence: RIQLKDHIDRSRKKRGEKEETE | ||||||
Region | 299-347 | Disordered | ||||
Sequence: RIQLKDHIDRSRKKRGEKEETEYEYSGSEEEDDSHGEEGEPSSIMNVPG | ||||||
Compositional bias | 321-335 | Acidic residues | ||||
Sequence: YEYSGSEEEDDSHGE | ||||||
Compositional bias | 363-381 | Polar residues | ||||
Sequence: KSNSEALKQQQQLQQQQQR | ||||||
Region | 363-383 | Disordered | ||||
Sequence: KSNSEALKQQQQLQQQQQRDP | ||||||
Compositional bias | 395-467 | Basic and acidic residues | ||||
Sequence: QRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQR | ||||||
Region | 395-890 | Disordered | ||||
Sequence: QRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQRQLQQEHAYLNSQKQQQQQQQQQQQQQQQQILPGDRKPLYHYGRGINPADKPAWAREVEERARMNKQQNSPLAKTKPSSAGPEPPIPQASPSPPGPLSQTPPMQRPVEPQEGPHKSLVAHRVPLKPYAAPVPRSQSLQDQPTRNLAAFPASHDPDPAAVPTPTATPSARGAVIRQNSDPTSEGPGPSPNPPSWVRPDNEAPPKVPQRTSSIATALNTSGAGGSRPAQAVRARPRSNSAWQIYLQRRAERGTPKPPGPPAQPPGPPNTSSNPDLRRSDPGWERSDSVLPASHGHLPQAGSLERNRNRVGASTKLDSSPVLSPGNKAKPEDHRSRPGRPADFVLLKERTLDEAPKPPKKAMDYSSSSEEVESSEDEEEEGDGEPSEGSRDTPGGRSDGDTDSVSTMVVHDVEEVSGTQPSYGGGTM | ||||||
Compositional bias | 468-499 | Polar residues | ||||
Sequence: QLQQEHAYLNSQKQQQQQQQQQQQQQQQQILP | ||||||
Compositional bias | 544-574 | Pro residues | ||||
Sequence: SSAGPEPPIPQASPSPPGPLSQTPPMQRPVE | ||||||
Compositional bias | 634-648 | Polar residues | ||||
Sequence: ARGAVIRQNSDPTSE | ||||||
Compositional bias | 649-664 | Pro residues | ||||
Sequence: GPGPSPNPPSWVRPDN | ||||||
Compositional bias | 669-689 | Polar residues | ||||
Sequence: KVPQRTSSIATALNTSGAGGS | ||||||
Compositional bias | 717-734 | Pro residues | ||||
Sequence: TPKPPGPPAQPPGPPNTS | ||||||
Compositional bias | 769-784 | Polar residues | ||||
Sequence: NRNRVGASTKLDSSPV | ||||||
Compositional bias | 790-829 | Basic and acidic residues | ||||
Sequence: KAKPEDHRSRPGRPADFVLLKERTLDEAPKPPKKAMDYSS | ||||||
Compositional bias | 832-848 | Acidic residues | ||||
Sequence: EEVESSEDEEEEGDGEP | ||||||
Region | 870-1336 | Mediates interaction with RAP2A | ||||
Sequence: MVVHDVEEVSGTQPSYGGGTMVVQRTPEEERSLLLADSNGYTNLPDVVQPSHSPTENSQGQSPPTKDGGGDYQSRGLVKAPGKSSFTMFVDLGIYQPGGSGDTIPITALVGGEGGRLDQLQFDVRKGSVVNVNPTNTRAHSETPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIVFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLNRNCIMNW | ||||||
Compositional bias | 909-937 | Polar residues | ||||
Sequence: GYTNLPDVVQPSHSPTENSQGQSPPTKDG | ||||||
Region | 909-946 | Disordered | ||||
Sequence: GYTNLPDVVQPSHSPTENSQGQSPPTKDGGGDYQSRGL | ||||||
Domain | 1023-1310 | CNH | ||||
Sequence: NSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYGLIGRRRFQQMDVLEGLNLLITISGKRNKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDMEGCGHYRVVKYERIKFLVIALKNSVEVYAWAPKPYHKFMAFKSFADLPHRPLLVDLTVEEGQRLKVIYGSSAGFHAVDVDSGNSYDIYIPVHIQSQITPHAIVFLPNTDGMEMLLCYEDEGVYVNTYGRIIKDVVLQWGEMPTSVAYICSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKV |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,336
- Mass (Da)150,382
- Last updated2011-10-19 v2
- ChecksumA10289483BCD2F2D
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F1LN69 | F1LN69_RAT | Mink1 | 1355 | ||
A0A0G2K382 | A0A0G2K382_RAT | Mink1 | 1316 | ||
A0A8I6B5X1 | A0A8I6B5X1_RAT | Mink1 | 1347 | ||
A0A0G2JV77 | A0A0G2JV77_RAT | Mink1 | 1346 | ||
A0A8I5ZKJ7 | A0A8I5ZKJ7_RAT | Mink1 | 1332 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 299-320 | Basic and acidic residues | ||||
Sequence: RIQLKDHIDRSRKKRGEKEETE | ||||||
Compositional bias | 321-335 | Acidic residues | ||||
Sequence: YEYSGSEEEDDSHGE | ||||||
Compositional bias | 363-381 | Polar residues | ||||
Sequence: KSNSEALKQQQQLQQQQQR | ||||||
Compositional bias | 395-467 | Basic and acidic residues | ||||
Sequence: QRRIEEQKEERRRVEEQQRREREQRKLQEKEQQRRLEDMQALRREEERRQAEREQEYKRKQLEEQRQSERLQR | ||||||
Compositional bias | 468-499 | Polar residues | ||||
Sequence: QLQQEHAYLNSQKQQQQQQQQQQQQQQQQILP | ||||||
Compositional bias | 544-574 | Pro residues | ||||
Sequence: SSAGPEPPIPQASPSPPGPLSQTPPMQRPVE | ||||||
Compositional bias | 634-648 | Polar residues | ||||
Sequence: ARGAVIRQNSDPTSE | ||||||
Compositional bias | 649-664 | Pro residues | ||||
Sequence: GPGPSPNPPSWVRPDN | ||||||
Compositional bias | 669-689 | Polar residues | ||||
Sequence: KVPQRTSSIATALNTSGAGGS | ||||||
Compositional bias | 717-734 | Pro residues | ||||
Sequence: TPKPPGPPAQPPGPPNTS | ||||||
Compositional bias | 769-784 | Polar residues | ||||
Sequence: NRNRVGASTKLDSSPV | ||||||
Compositional bias | 790-829 | Basic and acidic residues | ||||
Sequence: KAKPEDHRSRPGRPADFVLLKERTLDEAPKPPKKAMDYSS | ||||||
Compositional bias | 832-848 | Acidic residues | ||||
Sequence: EEVESSEDEEEEGDGEP | ||||||
Compositional bias | 909-937 | Polar residues | ||||
Sequence: GYTNLPDVVQPSHSPTENSQGQSPPTKDG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AABR03073855 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |