F1LP66 · F1LP66_RAT
- ProteinStress-activated protein kinase JNK
- GeneMapk8
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids418 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | JUN kinase activity | |
Molecular Function | protein serine kinase activity | |
Biological Process | rhythmic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameStress-activated protein kinase JNK
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionF1LP66
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-321 | Protein kinase | ||||
Sequence: YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYI | ||||||
Region | 366-418 | Disordered | ||||
Sequence: RGQPSPLAVINGSQHPSSSPSVNDMSSMSTDPTLASDTDSSLEASAGPLGCCR | ||||||
Compositional bias | 372-408 | Polar residues | ||||
Sequence: LAVINGSQHPSSSPSVNDMSSMSTDPTLASDTDSSLE |
Sequence similarities
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length418
- Mass (Da)46,974
- Last updated2022-05-25 v4
- Checksum79EB6481181C8376
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P49185 | MK08_RAT | Mapk8 | 411 | ||
A0A8I6B4F5 | A0A8I6B4F5_RAT | Mapk8 | 427 | ||
A0A0G2KA63 | A0A0G2KA63_RAT | Mapk8 | 308 | ||
A0A8I5ZXC7 | A0A8I5ZXC7_RAT | Mapk8 | 427 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 372-408 | Polar residues | ||||
Sequence: LAVINGSQHPSSSPSVNDMSSMSTDPTLASDTDSSLE |
Keywords
- Technical term