F1LP66 · F1LP66_RAT

  • Protein
    Stress-activated protein kinase JNK
  • Gene
    Mapk8
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionJUN kinase activity
Molecular Functionprotein serine kinase activity
Biological Processrhythmic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Stress-activated protein kinase JNK
  • EC number

Gene names

    • Name
      Mapk8

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    F1LP66

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain26-321Protein kinase
Region366-418Disordered
Compositional bias372-408Polar residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    418
  • Mass (Da)
    46,974
  • Last updated
    2022-05-25 v4
  • Checksum
    79EB6481181C8376
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAVIYIPMSHSSSSFSELIYKEVMDLEERTKNGVIRGQPSPLAVINGSQHPSSSPSVNDMSSMSTDPTLASDTDSSLEASAGPLGCCR

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
P49185MK08_RATMapk8411
A0A8I6B4F5A0A8I6B4F5_RATMapk8427
A0A0G2KA63A0A0G2KA63_RATMapk8308
A0A8I5ZXC7A0A8I5ZXC7_RATMapk8427

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias372-408Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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