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F1LNG5 · F1LNG5_RAT

  • Protein
    Phosphatidylinositol 3-kinase regulatory subunit alpha
  • Gene
    Pik3r1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell-cell junction
Cellular Componentcis-Golgi network
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componentperinuclear endoplasmic reticulum membrane
Cellular Componentphosphatidylinositol 3-kinase complex, class IA
Molecular Function1-phosphatidylinositol-3-kinase regulator activity
Molecular FunctionErbB-3 class receptor binding
Molecular Functioninsulin binding
Molecular Functioninsulin receptor binding
Molecular Functioninsulin receptor substrate binding
Molecular Functioninsulin-like growth factor receptor binding
Molecular Functionkinase activator activity
Molecular Functionneurotrophin TRKA receptor binding
Molecular Functionphosphatidylinositol 3-kinase regulator activity
Molecular Functionphosphatidylinositol 3-kinase regulatory subunit binding
Molecular Functionphosphotyrosine residue binding
Molecular Functionprotein heterodimerization activity
Molecular Functionprotein phosphatase binding
Biological ProcessB cell differentiation
Biological Processcellular response to UV
Biological Processextrinsic apoptotic signaling pathway via death domain receptors
Biological Processgrowth hormone receptor signaling pathway
Biological Processinsulin receptor signaling pathway
Biological Processinsulin-like growth factor receptor signaling pathway
Biological Processinterleukin-18-mediated signaling pathway
Biological Processintracellular glucose homeostasis
Biological Processintrinsic apoptotic signaling pathway in response to DNA damage
Biological Processmyeloid leukocyte migration
Biological Processnatural killer cell mediated cytotoxicity
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of cell-matrix adhesion
Biological Processnegative regulation of osteoclast differentiation
Biological Processnegative regulation of stress fiber assembly
Biological Processosteoclast differentiation
Biological Processphosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpositive regulation of endoplasmic reticulum unfolded protein response
Biological Processpositive regulation of filopodium assembly
Biological Processpositive regulation of focal adhesion disassembly
Biological Processpositive regulation of lamellipodium assembly
Biological Processpositive regulation of leukocyte migration
Biological Processpositive regulation of protein import into nucleus
Biological Processpositive regulation of RNA splicing
Biological Processpositive regulation of smooth muscle cell proliferation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of tumor necrosis factor production
Biological Processprotein import into nucleus
Biological Processprotein stabilization
Biological Processregulation of protein localization to plasma membrane
Biological Processregulation of toll-like receptor 4 signaling pathway
Biological Processresponse to endoplasmic reticulum stress
Biological Processtranscription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylinositol 3-kinase regulatory subunit alpha
  • Alternative names
    • Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha

Gene names

    • Name
      Pik3r1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    F1LNG5

Proteomes

Organism-specific databases

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the PI3K p85 subunit family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    724
  • Mass (Da)
    83,516
  • Last updated
    2013-04-03 v2
  • MD5 Checksum
    5B87C13FA7186FA4066B0C4D9D7B27C5
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEDIGWLNGYNETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKTEADTEQPVLTLPDLAEQFAPPDVAPPLLIKLLEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASVDLDVFDVHVLADAFKRYLADLPNPVIPVAVYNEMMSLAQEVPSSEDYIQLLKKLIRSPNIPHQYWLTLQYLLKHFFKLSQASSKNLLNARALSEIFSHVLFRFPAASSDNTEHLIKAVELLISTEWSERQPAPALPPKPPKPTSIANNSMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNHDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q63787P85A_RATPik3r1724
M0RC47M0RC47_RATPik3r1454

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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