F1LM47 · F1LM47_RAT

  • Protein
    Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
  • Gene
    Sucla2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for site, binding site.

Type
IDPosition(s)Description
Site96Important for substrate specificity
Binding site100ATP (UniProtKB | ChEBI)
Binding site107-109ATP (UniProtKB | ChEBI)
Site164Important for substrate specificity
Binding site260Mg2+ (UniProtKB | ChEBI)
Binding site274Mg2+ (UniProtKB | ChEBI)
Binding site325substrate; ligand shared with subunit alpha
Binding site382-384substrate; ligand shared with subunit alpha

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentsuccinate-CoA ligase complex
Cellular Componentsuccinate-CoA ligase complex (ADP-forming)
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Biological Processsuccinate metabolic process
Biological Processsuccinyl-CoA metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial
  • EC number
  • Alternative names
    • ATP-specific succinyl-CoA synthetase subunit beta
      (A-SCS
      )
    • Succinyl-CoA synthetase beta-A chain
      (SCS-betaA
      )

Gene names

    • Name
      Sucla2
    • Synonyms
      SUCLA2

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    F1LM47

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP. Interacts with ALAS2.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain63-290ATP-grasp

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    465
  • Mass (Da)
    50,306
  • Last updated
    2011-05-03 v1
  • Checksum
    4A148D18475E621D
MAASMFFGRQLAAAALRSHRSQTTVRATAQALGSSGLFNKHGFQMQQQQQQQRSLSLHEYLSMELLQEAGVSVPKGFVAKSSDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFTSGLKGGVKIVFSPEEAKAVSSQMIGQKLITKQTGAKGRICNQVLVCERKYPRREYYFAITMERSFQGPVLIGSSQGGVNIEDVAAENPEAIVKEPVDIIEGVKKEQAVTLAKKMGFPSNIVDSAAENMIKLYNLFLKYDATMVEINPMVEDADGKVLCMDAKINFDSNSAYRQKKIFALQDWSQEDERDKDAADADINYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEAFKLITSDKRVQAILVNIFGGIMRCDIIAQGIVMAVKDLEIRIPVVVRLQGTRVDDAKALIADSGLKILACDDLDEAAKMVVKLSEIVTLAKEAHVDVKFQLPI

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6A1U8A0A8I6A1U8_RATSucla2458

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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