F1K208 · F1K208_HV1
- ProteinPol protein
- Genepol
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1005 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
Features
Showing features for dna binding.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
DNA binding | 940-987 | Integrase-type | ||||
Sequence: FRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRD |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | aspartic-type endopeptidase activity | |
Molecular Function | DNA binding | |
Molecular Function | exoribonuclease H activity | |
Molecular Function | RNA stem-loop binding | |
Molecular Function | RNA-directed DNA polymerase activity | |
Molecular Function | RNA-DNA hybrid ribonuclease activity | |
Molecular Function | zinc ion binding | |
Biological Process | DNA integration | |
Biological Process | DNA recombination | |
Biological Process | establishment of integrated proviral latency | |
Biological Process | proteolysis | |
Biological Process | symbiont entry into host cell | |
Biological Process | viral genome integration into host DNA |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageViruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Lentivirus
- Virus hosts
Accessions
- Primary accessionF1K208
Proteomes
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-50 | Disordered | ||||
Sequence: FFRENLAFPQGKAREFSSEQARANSPTSRELQVWGRDNNSLPEAGAGRQG | ||||||
Compositional bias | 17-35 | Polar residues | ||||
Sequence: SSEQARANSPTSRELQVWG | ||||||
Domain | 77-147 | Peptidase A2 | ||||
Sequence: KEALLDTGADDTVVEENLELQGRWKPKMIGGIGGFIKVKQYDEVPIEICGHKVEGTVLVGPTPVNIIGRNL | ||||||
Domain | 201-391 | Reverse transcriptase | ||||
Sequence: EGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFREQNPEIVIYQYMDDLYVGSDLEMGQHRAKIEELRTHLLRWGLTTPDKKHQKEPPFLWMGYEL | ||||||
Domain | 591-714 | RNase H type-1 | ||||
Sequence: ITGAETFYVDGAANRETKLGKAGYVTDRGRQKVVPLTDTTNQKTELQAIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESEIVNQIIEELIKKEKVYLAWVPAHKGIGGNEQVDKLVSSGIR | ||||||
Domain | 720-761 | Integrase-type | ||||
Sequence: DGIDKAQEDHEKYHTNWRAMVSDFNLPPVVAKEIVASCDKCQ | ||||||
Domain | 771-921 | Integrase catalytic | ||||
Sequence: VDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGPNFISTAVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEQLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDMI | ||||||
Domain | 940-987 | Integrase-type | ||||
Sequence: FRVYYRDSRDPLWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRD |
Sequence similarities
Belongs to the retroviral Pol polyprotein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,005
- Mass (Da)113,819
- Last updated2011-05-03 v1
- Checksum796A13DF0D0848E2
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: F | ||||||
Compositional bias | 17-35 | Polar residues | ||||
Sequence: SSEQARANSPTSRELQVWG |