F0VQH7 · F0VQH7_NEOCL

Function

function

Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.

Catalytic activity

  • Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
    EC:3.1.4.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular Function5'-3' exonuclease activity
Molecular Function5'-flap endonuclease activity
Molecular Functionflap-structured DNA binding
Molecular Functionmetal ion binding
Molecular Functionphosphodiesterase I activity
Biological Processinterstrand cross-link repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fanconi-associated nuclease
  • EC number

Gene names

    • ORF names
      NCLIV_064000

Organism names

  • Taxonomic identifier
  • Strain
    • Liverpool
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Neospora

Accessions

  • Primary accession
    F0VQH7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-52Disordered
Region66-199Disordered
Compositional bias77-112Polar residues
Compositional bias114-128Basic and acidic residues
Compositional bias175-189Polar residues
Region227-273Disordered
Compositional bias242-267Basic and acidic residues
Region353-390Disordered
Compositional bias415-442Basic and acidic residues
Region415-445Disordered
Region509-636Disordered
Compositional bias522-536Polar residues
Compositional bias607-625Polar residues
Region798-838Disordered
Compositional bias799-835Polar residues
Region997-1056Disordered
Compositional bias1005-1032Basic and acidic residues
Compositional bias1033-1050Polar residues
Compositional bias1225-1248Basic and acidic residues
Region1225-1287Disordered
Region1359-1394Disordered
Region1487-1642Disordered
Compositional bias1608-1625Basic and acidic residues
Region1748-1818Disordered
Region1965-2082Disordered
Compositional bias2028-2061Basic and acidic residues
Domain2077-2222VRR-NUC
Region2151-2178Disordered
Region2233-2421Disordered
Compositional bias2262-2277Polar residues
Compositional bias2312-2345Basic and acidic residues
Compositional bias2346-2360Polar residues
Compositional bias2375-2389Polar residues

Sequence similarities

Belongs to the FAN1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,446
  • Mass (Da)
    261,564
  • Last updated
    2011-05-03 v1
  • Checksum
    CEFCFB10D10FFAA5
MGKAAMDRPPPSRQANGRSPLTRTAGAPDTPRDAACAVQRRTARAPSESCRSLASSQAFVEVIEVSSHDEESASFTVDTDLRGSAQTDQSDQPFSNRQKRTRATSLRQARGATLRTSYERDENDRECRGSSPVPLPKGSAQPSTAVTSDAEDCREVRTPPQFIPPDGHRRDATTSEVCSGMSSELSLVSPSRGRMRPGSLDGGCPSTCLATEQGVASAQTPFAVDSECPGAGVSSELASKTRDVPKLSESRAVRRPTDERDGQTSERMRTSGEASVFPQVSECTCSTLALENGTEEPAAGVCPPWMWNFTAPVYACLEASCTFNSHLFSPSEKLDLRRLAHLLALPVLESDEKADRRETSCGPGLGADAAGESAQTRGEPGASERGSDQALSPGARLLFCRVLLQFSRTPRRELDFHSFPDGGQDRGRAALPKADETHPSRKAAAGRLPSPWLRLTPLLNRSRREVADPHAALSELRACGLLTVWDNTCGVHTAEDEATNVSGLRRGILSSADPLSPEQGDTVEGSDLQQAKAASSRSLVCAERGDSVESDASSLGRPIAPPSPRKQASDEASGCVRKLESASASFPGSSVPSGHRFALTPGQSGALVPGTGASSAETSSVSMRLGRQGAPPCDQRRGAAATLKDSLIAAFHCLTVPELQRLVMEVEAAMTSPRRASPVSSRFPGFSCSPLAARLRRLLPANRRNVVRLKGEQRLGPTFKRRPECLRFLCAAAEMAFASHRKTQGEDCPPFDASSWDALFPRAAPRGGLKPEQVEQQPVRMKKLTHFFKLASPAASENRSKWPLAQPSASKDRRGQPTRSQGVTNGASPRPSVASEAEVTSCPEAPFAPWGVQTPLRAAAEQPAESGPSLSQGECFLQMLREMLVACVGPLAAFQDQQVLRTWLVAFFAFHVVHSAFLNFFSRSAPPAAVLWTTRARPGRLRGACPISAAAPASENASSRSDAEETVFGLTAAAVAPAVTRLSGLVTYQLEVRLSQPGRRPGADRAVAELGRSPREDEAGTDNEEERPTDRRSVGTLQTSPSSPDQPGESEEESLSCGAAQRVLASACDAPAPSAAAAPAQDSACAAGGGREQTEPLGARTAGRNARAELCEACGGSAAAKKPRQLVAPPLRCVCCCCEYARSGHAIFPSRAAVFVYAAALLDKWRLAALLWGGLVLPAQGGEENPAEAAVLDIVESAAEKLRMYVEEAEGLLYRHLRRDVRRGEQTAAMDGKAVERAGAKESRHRGSEGPGSGGGKAELCGNPVTSHLSLGDEGMADWTEDSSPNSARLPQALEAAAPPSKLFRFTPHFVWAKTISHGLELVEQTKRHHRAVELLRLLLRFHGLRQVLAKSVASERGVRWPSDSPSLRAGTASRDTHEGEDVVRTTPSRPDLSAGGEAFWRRVRESCRHQPAVCRALSRHAGQWYNRLMVLLKIHLKHPTEALAVAVDCLREPRGAVSLAERLAMGKRATALAKAFAYAAEKATQTGEEGGARRCGGAAAGRHARKRGRAEGGDSNGEARQGHTVPQCWEDVRRLVGRPRETDAESGASGQRLQGLQQEGDSAGADLAGESAKQKTSRVSRSCRRRGTISADETSSDNAAPERIERSPGVSDPKAQRSRASRGPERSPEAAAAGPLPSSRESASLRSWTRFFPRDVHARLLETVELQRLLEKELPHSVVYARPLEATQQTGKSSVFFGWDGQLLSVEELCMQHYAMAGDWRGVHDEGRSLRTLFRLVMFDANRSLGEAGASEEETRLERGAHSGPSTQDADRDRAEADGASSEAKRASSEAKRERGGFELSADRLKQGEEAAVDREDGRCWRRRAPRGTRDGVGNADAKAEGSMESARDAAFVPIVFLPPSEPTVPSSISRGKLEGGDGEASFDDVALAGGVNQTPTRKACEREGDAQGLESAETPFSLEEPALKRALKVQEHLDLFAQMSRSTVAEAVGRTVRRLYGMRLPGVSWRGPWQDLEEAPGGPAEGGDSAEAAQDDQTRGAEAETAGFCGEPDETLSETPGQFVAGEGEGGEGKQEETPSEETHAGGPRPDTPGHEKAAPLEKVKPTVGRSPPEAPGPAREHALDARYRRGIQRERAKEACARFFSMLAYGIGGKGLSEVFRLLSDDFAYWAGGLPDLLLWRVSPANAPAGTVCTPQEAAGEKLESTNTRDGGGPKGDEKLGHLGEILFAEVKGPRDRLSEKQKCWLAHFLRAGVPCEVCKVLPPVQASEDLLRAPAASSVAGECLRGPRARRETRATQGDRPHASGGGSSSGDEASASVSSDPERRSEGETHVGAPPASPAKPQGPTKRTAPWGKTTEREDGEPRGVVDSGETQTRHGRETKETNRGTVSCEASRLPGESQTRQSKRGKKDCSFSGTRGGAQQSSVSNSELDKVGEKRGKSGAQKQVAGSFQTRPRGLPRVRVRADWEEHDAEKVEALCRRTRKKVF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias77-112Polar residues
Compositional bias114-128Basic and acidic residues
Compositional bias175-189Polar residues
Compositional bias242-267Basic and acidic residues
Compositional bias415-442Basic and acidic residues
Compositional bias522-536Polar residues
Compositional bias607-625Polar residues
Compositional bias799-835Polar residues
Compositional bias1005-1032Basic and acidic residues
Compositional bias1033-1050Polar residues
Compositional bias1225-1248Basic and acidic residues
Compositional bias1608-1625Basic and acidic residues
Compositional bias2028-2061Basic and acidic residues
Compositional bias2262-2277Polar residues
Compositional bias2312-2345Basic and acidic residues
Compositional bias2346-2360Polar residues
Compositional bias2375-2389Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FR823393
EMBL· GenBank· DDBJ
CBZ55974.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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