F0VQH7 · F0VQH7_NEOCL
- ProteinFanconi-associated nuclease
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2446 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.
Catalytic activity
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | 5'-3' exonuclease activity | |
Molecular Function | 5'-flap endonuclease activity | |
Molecular Function | flap-structured DNA binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphodiesterase I activity | |
Biological Process | interstrand cross-link repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFanconi-associated nuclease
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Conoidasida > Coccidia > Eucoccidiorida > Eimeriorina > Sarcocystidae > Neospora
Accessions
- Primary accessionF0VQH7
Proteomes
Organism-specific databases
Subcellular Location
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-52 | Disordered | |||
Region | 66-199 | Disordered | |||
Compositional bias | 77-112 | Polar residues | |||
Compositional bias | 114-128 | Basic and acidic residues | |||
Compositional bias | 175-189 | Polar residues | |||
Region | 227-273 | Disordered | |||
Compositional bias | 242-267 | Basic and acidic residues | |||
Region | 353-390 | Disordered | |||
Compositional bias | 415-442 | Basic and acidic residues | |||
Region | 415-445 | Disordered | |||
Region | 509-636 | Disordered | |||
Compositional bias | 522-536 | Polar residues | |||
Compositional bias | 607-625 | Polar residues | |||
Region | 798-838 | Disordered | |||
Compositional bias | 799-835 | Polar residues | |||
Region | 997-1056 | Disordered | |||
Compositional bias | 1005-1032 | Basic and acidic residues | |||
Compositional bias | 1033-1050 | Polar residues | |||
Compositional bias | 1225-1248 | Basic and acidic residues | |||
Region | 1225-1287 | Disordered | |||
Region | 1359-1394 | Disordered | |||
Region | 1487-1642 | Disordered | |||
Compositional bias | 1608-1625 | Basic and acidic residues | |||
Region | 1748-1818 | Disordered | |||
Region | 1965-2082 | Disordered | |||
Compositional bias | 2028-2061 | Basic and acidic residues | |||
Domain | 2077-2222 | VRR-NUC | |||
Region | 2151-2178 | Disordered | |||
Region | 2233-2421 | Disordered | |||
Compositional bias | 2262-2277 | Polar residues | |||
Compositional bias | 2312-2345 | Basic and acidic residues | |||
Compositional bias | 2346-2360 | Polar residues | |||
Compositional bias | 2375-2389 | Polar residues | |||
Sequence similarities
Belongs to the FAN1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,446
- Mass (Da)261,564
- Last updated2011-05-03 v1
- ChecksumCEFCFB10D10FFAA5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 77-112 | Polar residues | |||
Compositional bias | 114-128 | Basic and acidic residues | |||
Compositional bias | 175-189 | Polar residues | |||
Compositional bias | 242-267 | Basic and acidic residues | |||
Compositional bias | 415-442 | Basic and acidic residues | |||
Compositional bias | 522-536 | Polar residues | |||
Compositional bias | 607-625 | Polar residues | |||
Compositional bias | 799-835 | Polar residues | |||
Compositional bias | 1005-1032 | Basic and acidic residues | |||
Compositional bias | 1033-1050 | Polar residues | |||
Compositional bias | 1225-1248 | Basic and acidic residues | |||
Compositional bias | 1608-1625 | Basic and acidic residues | |||
Compositional bias | 2028-2061 | Basic and acidic residues | |||
Compositional bias | 2262-2277 | Polar residues | |||
Compositional bias | 2312-2345 | Basic and acidic residues | |||
Compositional bias | 2346-2360 | Polar residues | |||
Compositional bias | 2375-2389 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FR823393 EMBL· GenBank· DDBJ | CBZ55974.1 EMBL· GenBank· DDBJ | Genomic DNA |