F0V3B1 · F0V3B1_MYCS3

Function

function

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site17-23GTP (UniProtKB | ChEBI)
Active site18Proton acceptor
Binding site18Mg2+ (UniProtKB | ChEBI)
Binding site18-21IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site43-46IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site45Mg2+ (UniProtKB | ChEBI)
Binding site45-47GTP (UniProtKB | ChEBI)
Active site46Proton donor
Binding site133IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Active site144
Binding site147IMP (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site227IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site242IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site304-310substrate
Binding site308IMP (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site310GTP (UniProtKB | ChEBI)
Binding site336-338GTP (UniProtKB | ChEBI)
Binding site420-422GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionadenylosuccinate synthase activity
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Biological Process'de novo' AMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenylosuccinate synthetase
  • EC number
  • Short names
    AMPSase
    ; AdSS
  • Alternative names
    • IMP--aspartate ligase

Gene names

    • Name
      purA
    • ORF names
      MSUIS_02400

Organism names

Accessions

  • Primary accession
    F0V3B1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the adenylosuccinate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    433
  • Mass (Da)
    48,759
  • Last updated
    2011-05-03 v1
  • Checksum
    84A40C5F19C77DFE
MSKEKGHAIGVVGLQFGDEGKGKIVDLLSSEYDYVVRYQGGDNAGHTLYHNGKKCVLRSIPSGIFNTAGIIAPGVVVNPALLLEEISSIENLKGESLKGKLFISTQANVIFDFHIEWDKLCEKLREKSKIGSTLRGIGPAYADKNARIGMKLIDLFDVEKLNRRLKVNLQLKNPIFEKYGFSPFVPEQLSEKYNKLIHQLKPYLVDYYSFITEKMKEGSSFLLEGSQGLLLDIDLGTYPFVTSSNIASAILHGGYMPAKSIKKLIGVVKAYTTRVGEGPLITELGESEKEIEETVRERGHEYGSNTARARRIGWLDLKALSYSIQVVGIDEIVLTLVDVFNGFETIKVCTDYEDLSGRKLLFPEATHLFEQNKVKPIYKVFKAWNENYSNISKYEDFSPEFKEFVSFIEDYLKLKVSAVSFGRHKEESVFKIN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FQ790233
EMBL· GenBank· DDBJ
CBZ40333.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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