F0UD48 · F0UD48_AJEC8

Function

function

Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular ComponentGolgi apparatus
Cellular Componentmembrane
Biological ProcessGolgi to endosome transport
Biological ProcessGolgi to vacuole transport
Biological Processprotein targeting to vacuole

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Vacuolar protein sorting/targeting protein 10
  • Alternative names
    • Carboxypeptidase Y receptor
    • Sortilin VPS10
    • Vacuolar carboxypeptidase Sorting receptor VPS10

Gene names

    • Name
      VPS10
    • ORF names
      HCEG_02689
      , I7I53_10063

Organism names

Accessions

  • Primary accession
    F0UD48

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus, trans-Golgi network membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein
Prevacuolar compartment membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane1362-1383Helical
Transmembrane1409-1432Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_503397249722-1497Vacuolar protein sorting/targeting protein 10

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain49-673VPS10
Domain709-1350VPS10
Region1474-1497Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,497
  • Mass (Da)
    168,414
  • Last updated
    2011-05-03 v1
  • Checksum
    07A89006B34E9E8C
MILRRLLLAGSLLLATAFTSAKKADGPKISVTKFKDEPVNLFYFDDSDTVMFQDGKNGDVYVSRDAGANWDIVDVSGMRGKAWSLLPHPTDRTKAYIMSNGGTHWVTEDQAKSWREFTVDADLSRYEYPLVFHGKDSNRVMLLGHKCNGLDCKEKTYYTTDGFKTAHLLMENGRHCAWAVSTPTFGEGLDLPKEVNDRIFCVVSGLHSSWAEANRLLYSDRFFKDEQGTEVPLDNGRAVSGVIRTASVQKYILAATKSARTNELALFVTDNASTWHRTEFDGHRVEEDAYTILESTSYSLQVDVVSTYSSTIGTLFTSNSNGTYFTRNIEHTNRNMYGFVDFEKISSIQGIILVNTVKNWEDVEKSNGVQKKVISKISFDDGRTFQPLKVGKHDLHLHSVTDATNSGRVFSSPAPGLVMGVGNTGGHLKDYLDGDLFVSDDAGINWRKALDDAHKYEFGDQGSVIVAVFDEGRTDKISYSLDHGKNWHKASLPDGVQIRAKVLTTAPGSTTLKFLLLGSAKADIGMEYYIISIDFAEMEERTCEEKDFENWPARLNEKNEPDCLMGHKQFYRRRKAQADCFIKKKFEEPAPEFERCKCTEEDFECDFNFVRGEDGKSCIPSRSLIAPEGVCKNPDDKFTGSSGFRLIPGNVCIREGGVDLDKQTERVCSETFKNPPAGQIVVEKSFFTADYYKDYFYLERKESSKGEDETVIMITSEQQIFLSRDHGKKWKQILEEEKITRIEPHRFFDDVAYFLTNNGDGWYTLDRGDTFRKFKAPLPPNQDKLPVLSFHPDRRDWLIWTGADECNGNGGNCHSVAYYTTNLGGEWHFLMRYVRRCEFISRDARGSSDKLVFCEQFENENPSNKHLQLLSTEDWFAEKRLHYSNILDFATMQEFIIVAIRGENSQDSLRIGVSIDGKTFADAELPANVQIPIQRAYTVLESRTHAAFLHVTINNIEDHEYGSIIKSNSNGTSYVLSLSAVNRNSRGYADFEKMQGLEGVAMANVVGNVPDVENGAAKKFRTMITHNDGAEWTLMRPPDKDSEGRSYACSTKGGKPTDACALHLHSYTERADPRDTYSSPSAVGIMIGTGNVGDYLSLKSKADTFITRDAGITWEEVKKGKYQWEFGDSGSIIVLVPESTPTKTLLYSLDEGRSWKDFEFSEVEMQIQDISTVPSDTSRNFLLWGKEVGQGKKPGIATVNIDFSGLKERSKQCVLDEKKPEADDYYLWEPKHPLQPNGCLFGHRAKYHRKRPDKDCYNGRELQHLDSIGDICECTRSDYECDYNYEPQSDGSCARVAGLEPLDPKLVCTENPKAVEWYEPTGYRRIPLTKCQGGKQLNHIVAHPCPNKEEEFFKKHPRLRGIGLFFVILIPICLAATAGYYVYNHWDGKFGRIRLGETGSGGLFDRDSLLVSIPVSMVAGVVAVITALPLLVSSLWRSVSGYVRVPGGASSRRPYSSRDSFAARRSDYVGVVEDEDELLGTDDFDDDEEGDERNGQV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS990637
EMBL· GenBank· DDBJ
EGC43474.1
EMBL· GenBank· DDBJ
Genomic DNA
CP069102
EMBL· GenBank· DDBJ
QSS49652.1
EMBL· GenBank· DDBJ
Genomic DNA

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