F0T8L4 · F0T8L4_METLA
- ProteinCoenzyme A biosynthesis bifunctional protein CoaBC
- GenecoaBC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids381 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
Catalytic activity
- (R)-4'-phosphopantothenate + L-cysteine + CTP = N-[(R)-4-phosphopantothenoyl]-L-cysteine + CMP + diphosphate + H+
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FMN per subunit.
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | phosphopantothenoylcysteine decarboxylase complex | |
Molecular Function | FMN binding | |
Molecular Function | metal ion binding | |
Molecular Function | phosphopantothenate--cysteine ligase activity | |
Molecular Function | phosphopantothenoylcysteine decarboxylase activity | |
Biological Process | coenzyme A biosynthetic process | |
Biological Process | pantothenate catabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCoenzyme A biosynthesis bifunctional protein CoaBC
- Alternative names
Including 2 domains:
- Recommended namePhosphopantothenoylcysteine decarboxylase
- EC number
- Short namesPPC decarboxylase ; PPC-DC
- Alternative names
- Recommended namePhosphopantothenate--cysteine ligase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanobacterium
Accessions
- Primary accessionF0T8L4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-158 | Flavoprotein | ||||
Sequence: MEIVLCVTGSIAATECVKLARELKRQGFDVKCFMSEDACNIIHPNAMEFATGQKVVTELTGDIEHVKYAQTDLILVAPATANIISKFAYKMADNPISTLLITGFGYQTPTVFVPSMHESMYRAVSQNIDGLKEEGILFLEPKREEGKAKFPDINDIVL | ||||||
Region | 1-173 | Phosphopantothenoylcysteine decarboxylase | ||||
Sequence: MEIVLCVTGSIAATECVKLARELKRQGFDVKCFMSEDACNIIHPNAMEFATGQKVVTELTGDIEHVKYAQTDLILVAPATANIISKFAYKMADNPISTLLITGFGYQTPTVFVPSMHESMYRAVSQNIDGLKEEGILFLEPKREEGKAKFPDINDIVLQALRETSEGKLRGKK | ||||||
Domain | 169-354 | DNA/pantothenate metabolism flavoprotein C-terminal | ||||
Sequence: LRGKKVLISAGGTYEAIDSVRGITNMSSGKMGLEIAREAFIQGADVTMVNGRVDVPIPSLFERFDVTSASEMINKLTDLLPENDIFISAAAVSDFKLECSDSQKISSDDDLIIHFKPGPKILNMVKELNPNIFLVGFKAESNISEEELVISARKQIEKSGADFVVANDISIEGSGFGSEKNQVVIV | ||||||
Region | 174-381 | Phosphopantothenate--cysteine ligase | ||||
Sequence: VLISAGGTYEAIDSVRGITNMSSGKMGLEIAREAFIQGADVTMVNGRVDVPIPSLFERFDVTSASEMINKLTDLLPENDIFISAAAVSDFKLECSDSQKISSDDDLIIHFKPGPKILNMVKELNPNIFLVGFKAESNISEEELVISARKQIEKSGADFVVANDISIEGSGFGSEKNQVVIVDDDTSSVPLCSKQEVAKKIVEKIIERV |
Sequence similarities
In the C-terminal section; belongs to the PPC synthetase family.
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length381
- Mass (Da)41,667
- Last updated2011-05-03 v1
- Checksum975849501D14799A
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002551 EMBL· GenBank· DDBJ | ADZ08556.1 EMBL· GenBank· DDBJ | Genomic DNA |