F0NFD1 · F0NFD1_SULIR
- ProteindITP/XTP pyrophosphatase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids192 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Catalytic activity
- H2O + ITP = diphosphate + H+ + IMP
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 12-17 | substrate | ||||
Sequence: TSNENK | ||||||
Binding site | 41 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Active site | 70 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 70 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 71 | substrate | ||||
Sequence: S | ||||||
Binding site | 145-148 | substrate | ||||
Sequence: FGFD | ||||||
Binding site | 168 | substrate | ||||
Sequence: K | ||||||
Binding site | 173-174 | substrate | ||||
Sequence: HR |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dITP diphosphatase activity | |
Molecular Function | ITP diphosphatase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Molecular Function | ribonucleoside triphosphate phosphatase activity | |
Molecular Function | XTP diphosphatase activity | |
Biological Process | nucleotide metabolic process | |
Biological Process | purine nucleoside triphosphate catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namedITP/XTP pyrophosphatase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Thermoproteota > Thermoprotei > Sulfolobales > Sulfolobaceae > Sulfolobus
Accessions
- Primary accessionF0NFD1
Proteomes
Interaction
Structure
Family & Domains
Features
Showing features for coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 18-45 | |||||
Sequence: FIELKELAKSFNIELEQLKGEKIEIQSD |
Sequence similarities
Belongs to the HAM1 NTPase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length192
- Mass (Da)21,956
- Last updated2011-05-03 v1
- Checksum02398C2E3216881F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002425 EMBL· GenBank· DDBJ | ADX85635.1 EMBL· GenBank· DDBJ | Genomic DNA |