F0NFD1 · F0NFD1_SULIR

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site12-17substrate
Binding site41Mg2+ (UniProtKB | ChEBI)
Active site70Proton acceptor
Binding site70Mg2+ (UniProtKB | ChEBI)
Binding site71substrate
Binding site145-148substrate
Binding site168substrate
Binding site173-174substrate

GO annotations

AspectTerm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Ordered locus names
      SiRe_1571

Organism names

Accessions

  • Primary accession
    F0NFD1

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil18-45

Sequence similarities

Belongs to the HAM1 NTPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    192
  • Mass (Da)
    21,956
  • Last updated
    2011-05-03 v1
  • Checksum
    02398C2E3216881F
MLRRDVRIGVVTSNENKFIELKELAKSFNIELEQLKGEKIEIQSDNLEEISKTAAYLAYLTFRRPLIVDDSGLFIETLQNFPGPYTNFVKNTIGLKGILKLLEDLKDRSAYFMTVLTFTDGKIIKTFNGIVKGVISEEIRGNSGFGFDPIFIPEGEKRTFAEMSLEEKNKYSHRARAFAKFADFLMSYLEKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002425
EMBL· GenBank· DDBJ
ADX85635.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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