F0M8W2 · F0M8W2_PSEPM

Function

function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.

Catalytic activity

Cofactor

biotin (UniProtKB | Rhea| CHEBI:57586 )

Features

Showing features for binding site, active site.

111311002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site117ATP (UniProtKB | ChEBI)
Binding site200ATP (UniProtKB | ChEBI)
Binding site235ATP (UniProtKB | ChEBI)
Active site296
Binding site537Mn2+ (UniProtKB | ChEBI)
Binding site609substrate
Binding site707Mn2+ (UniProtKB | ChEBI); via carbamate group
Binding site736Mn2+ (UniProtKB | ChEBI)
Binding site738Mn2+ (UniProtKB | ChEBI)
Binding site871substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionpyruvate carboxylase activity
Biological Processgluconeogenesis
Biological Processpyruvate metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyruvate carboxylase
  • EC number

Gene names

    • Ordered locus names
      Asphe3_15280

Organism names

Accessions

  • Primary accession
    F0M8W2

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue707N6-carboxylysine
Modified residue1097N6-biotinyllysine

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-454Biotin carboxylation
Domain121-321ATP-grasp
Domain528-797Pyruvate carboxyltransferase
Domain1057-1131Lipoyl-binding

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,131
  • Mass (Da)
    121,405
  • Last updated
    2011-05-03 v1
  • Checksum
    D3C302CB351FF197
MFSKVLVANRGEIAIRAFRAGYELGAKTVAVFPQEDRNSIHRQKADEAYLIGEEGHPVRAYLDVDEVVRVAKESGADAIYPGYGFLSENPDLARAAKAAGITFVGPPAEVLELAGNKVAALKAARDAGVPVLKSSAPSKDLDELIAAADEIGFPIFAKAVAGGGGRGMRRVDTREALPEALQSAMREADAAFGDPTMFLEQAVLRPRHIEVQILADAQGNVMHLFERDCSIQRRHQKVIEIAPAPNLDENIRQALYRDAVKFAQALNYVNAGTVEFLVDTVGERAGQHVFIEMNPRIQVEHTVTEEVTDVDLVQAQMRIAAGETLADLGLSQDTVRLRGAALQSRITTEDPANGFRPDVGKITGYRSAGGAGVRLDGGTVYSGAEISPHFDSMLVKLTCRGRDYPSAVARARRALAEFRIRGVSTNISFLQAVLDDPDFIAGDVATSFIDERPQLLKARVSADRGTKLLTWLADVTVNKPNGELKVHSNPARKLPSVKDKEAAPGSRQRLLELGPEGFARALREQNAVAVTDTTFRDAHQSLLATRVRTRDLVAAGPAVTALMPELLSVEAWGGATYDVALRFLGEDPWDRLAALRAAMPNVCIQMLLRGRNTVGYTPYPEEVTEAFVNEAAATGIDIFRIFDALNDVSQMAPAIRAVRATGTAVAEVALCYTGDMLDPEEKLYTLDYYLELAQRIVDAGAHILAIKDMAGLLRPAAAAKLVSALRERFDLPVHLHTHDTAGGQLATLLAAVDAGVDAVDVASASLAGTTSQPSASALVAALAHTPRDTGLSLAAVSSLEPYWEAVRRVYAPFESGLPGPTGRVYQHEIPGGQLSNLRQQAMALGLGERFEAIEDMYTAADRILGHLVKVTPSSKVVGDLALHLVGLNADPADFEENPQNYDIPDSVIGFLSGELGDPPGGWPEPFRTKALQGRSVKVRDVELSAEDSAALKSDSKTRQHTLNRLLFDGPTKDYLKSVETYGNISVLDTRDYLYGLQRGQEHEIQLEKGVRLIASLEAVSEPDEKGMRTVMCTLNGQSRPVVVRDRSVVSNVKAAEKADPGQPGQVAAPFAGAVTVTVKPGDEVKAGDTVATIEAMKMEASITTPVAGKVSRLAISAVEQVEGGDLLLVVE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002379
EMBL· GenBank· DDBJ
ADX72697.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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