F0M144 · F0M144_PSEPM

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site82substrate
Binding site222-224substrate
Binding site231Mn2+ (UniProtKB | ChEBI)
Binding site251Mn2+ (UniProtKB | ChEBI)
Binding site273substrate
Binding site274-279GTP (UniProtKB | ChEBI)
Active site275
Binding site298Mn2+ (UniProtKB | ChEBI)
Binding site389-391substrate
Binding site391GTP (UniProtKB | ChEBI)
Binding site422GTP (UniProtKB | ChEBI)
Binding site517-520GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processgluconeogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • Ordered locus names
      Asphe3_07200

Organism names

Accessions

  • Primary accession
    F0M144

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-243Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain247-606Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    611
  • Mass (Da)
    67,185
  • Last updated
    2011-05-03 v1
  • Checksum
    3A3D8B00B7E3D1DD
MGDLAQKPLLEKAPTTHAGLLAWVEEVAELTQPDRIYWVDGSEEENTRLTDELVAAGTLTRLNQDLFPNSFAAFSDPADVARVEEQTFICSENKRDAGFTNNWMAPAEMKDKLRGLFAGSMRGRTMYVIPFVMGHLDAEDPKFGVEITDSAYVVASMRIMANIGTAVLDKITETNAFFVPALHSLGAPLEPGQADVPWPCNPDKWIVHFPEERSIWSFGSGYGGNALLGKKCYALRIASVMARDEGWLAEHMLILKLTSPEKKNYYISAAFPSACGKTNLALLDPTIEGWEVETLGDDITWMRIGKEGELRAINPEAGLFGVAPGTGWGTNPNAMRAIAKGHSIFTNVALTDDGGVWWEGMTDEVPAHLTDWQGNSWTPDSDKPAAHPNSRFCTPISQIDMLAEEYYSPEGVELSAILFGGRRKTTVPLVTQARSWTNGIFMGSTLSSETTAAAAGQVGVLRRDPMAMLPFIGYDAGDYLKHWISVSGKANPERLPHIFLVNWFRRTAEGGFAWPGFGDNARVLKWAIERLEGKAEAVETPIGYVPAGDSLDLTGLDLTHAHVEEAVRVDREEWDAELASIEDWYAQFGDSLPDALRAELEALKERMADHS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002379
EMBL· GenBank· DDBJ
ADX71927.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp