F0EUP9 · F0EUP9_HAEPA
- ProteinBifunctional chorismate mutase/prephenate dehydratase
- GenepheA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids385 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
Catalytic activity
- H+ + prephenate = 3-phenylpyruvate + CO2 + H2O
Pathway
Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.
Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9 | substrate | ||||
Sequence: R | ||||||
Binding site | 26 | substrate | ||||
Sequence: R | ||||||
Binding site | 37 | substrate | ||||
Sequence: K | ||||||
Binding site | 46 | substrate | ||||
Sequence: D | ||||||
Binding site | 50 | substrate | ||||
Sequence: E | ||||||
Binding site | 84 | substrate | ||||
Sequence: S | ||||||
Binding site | 88 | substrate | ||||
Sequence: Q | ||||||
Site | 278 | Essential for prephenate dehydratase activity | ||||
Sequence: T |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | chorismate mutase activity | |
Molecular Function | prephenate dehydratase activity | |
Biological Process | chorismate metabolic process | |
Biological Process | L-phenylalanine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional chorismate mutase/prephenate dehydratase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Haemophilus
Accessions
- Primary accessionF0EUP9
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-92 | Chorismate mutase | ||||
Sequence: MALDLSEIRQQITQIDRSLLKLLSERHRLAYDVVRSKEVTQKALRDLEREQQLLQELVQFAESQNYQLEPQYITSVFQKIIEDSVLTQQVYL | ||||||
Coiled coil | 37-64 | |||||
Sequence: KEVTQKALRDLEREQQLLQELVQFAESQ | ||||||
Domain | 105-285 | Prephenate dehydratase | ||||
Sequence: HIAFLGKRGSYSNLAARNYAARYHQQFAEISCDSFAQIFEKVESGEADYGVLPLENTTSGAINEVYDLLQHTTLSLVGELAYPIKHCVLVNEQDDLSKIDTLYSHPQVIQQCSQFIQSLERVHIEFCESSSHAMQLVASLNKPNIAALGNEDGGKLYGLHVLKHNIANQENNITRFIVVAK | ||||||
Domain | 299-376 | ACT | ||||
Sequence: LLLMTTSQQAGSLVDALLVFKKHGINMTKLESRPIYGKPWEEMFYLEIEGNIHHPDTQIALEELKQFSNYLKVLGCYP |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length385
- Mass (Da)43,971
- Last updated2011-05-03 v1
- Checksum5FBCDE93FEE796C5
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AEWU01000019 EMBL· GenBank· DDBJ | EGC71769.1 EMBL· GenBank· DDBJ | Genomic DNA |