E9QPD7 · E9QPD7_MOUSE
- ProteinPyruvate carboxylase
- GenePcx
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1179 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Publications for E9QPD7
Corrected centromere orientation for mouse chromosome 19 MIT markers.
- CategoriesFunction, Sequences
- SourceMGI: 97520
Adipose pyruvate carboxylase: amino acid sequence and domain structure deduced from cDNA sequencing.
- CategorySequences
- SourceMGI: 97520
Assignment of the human pyruvate carboxylase gene (PC) to 11q13.4 by fluorescence in situ hybridisation.
- CategoriesSequences, Expression
- SourceMGI: 97520
Molecular cloning of a cDNA for human pyruvate carboxylase. Structural relationship to other biotin-containing carboxylases and regulation of mRNA content in differentiating preadipocytes.
- AnnotationFocuses on cloning of human pyruvate carboxylase but also studies pyruvate carboxylase levels in mouse preadipocyte differentiation.
- CategorySequences
Genetic determinants of micronucleus formation in vivo.
- CategoryFunction
- SourceMGI: 97520
gamma-Linolenic acid in maternal milk drives cardiac metabolic maturation.
- CategoryFunction
- SourceMGI: 97520
Requirement of hepatic pyruvate carboxylase during fasting, high fat, and ketogenic diet.
- AnnotationRequirement of hepatic pyruvate carboxylase during fasting high fat and ketogenic diet.
- CategoriesFunction, Phenotypes & Variants
Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation.
- CategoryFunction
- SourceMGI: 97520
Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.
- AnnotationPyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.
- CategoryFunction
Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro.
- CategoryFunction
- SourceMGI: 97520
CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
- CategoryFunction
- SourceMGI: 97520
Hepatic Glucocorticoid Receptor Plays a Greater Role Than Adipose GR in Metabolic Syndrome Despite Renal Compensation.
- CategoriesFunction, Expression
- SourceMGI: 97520
High-throughput discovery of novel developmental phenotypes.
- CategoriesSequences, Phenotypes & Variants
- SourceMGI: 97520
The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic beta- cells.
- Annotationthe MDM2-p53-PC signalling axis links mitochondrial metabolism to insulin secretion and glucose homeostasis and could represent a therapeutic target in diabetes.
- CategoriesFunction, Phenotypes & Variants
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97520
Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97520
Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation.
- AnnotationThese findings indicate that PC-mediated anaplerosis in early-stage NSCLC is required for tumor survival and proliferation.
- CategoryExpression
- SourceGeneRif: 18563
TR4 promotes fatty acid synthesis in 3T3-L1 adipocytes by activation of pyruvate carboxylase expression.
- AnnotationTR4-mediated enhancement of fatty acid synthesis in adipocytes requires increased expression of PC gene
- CategoryFunction
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 97520