E9QM61 · E9QM61_MOUSE
- ProteinExcision repair cross-complementing rodent repair deficiency, complementation group 5
- GeneErcc5
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1170 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Publications for E9QM61
Molecular cloning and structural analysis of the functional mouse genomic XPG gene.
- CategoriesSequences
- SourceMGI: 103582
An ERCC5 gene with homology to yeast RAD2 is involved in group G Xeroderma pigmentosum.
- CategoriesSequences
- SourceMGI: 103582
Genome-wide RNA polymerase stalling shapes the transcriptome during aging.
- CategoriesFunction
- SourceMGI: 103582
Cellular senescence drives age-dependent hepatic steatosis.
- CategoriesFunction
- SourceMGI: 103582
Restricted diet delays accelerated ageing and genomic stress in DNA- repair-deficient mice.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 103582
Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.
- CategoriesFunction
- SourceMGI: 103582
A Cascade of epistatic interactions regulating teratozoospermia in mice.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 103582
Cell-autonomous progeroid changes in conditional mouse models for repair endonuclease XPG deficiency.
- CategoriesFunction, Phenotypes & Variants
- SourceMGI: 103582
Generation of DNA single-strand displacement by compromised nucleotide excision repair.
- AnnotationHIghlighted in this study is the crucial role of XPG's interactions with TFIIH for proper nucleotide excision repair
- CategoriesFunction
A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
- CategoriesExpression
- SourceMGI: 103582
Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells.
- AnnotationXPG gene expression can be influenced by an epigenetic mechanism. Restoration of NER activity through XPG gene transfer or treatment with demethylating agents restored sensitivity to nemorubicin.
- CategoriesFunction
- SourceGeneRif: 22592
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
- CategoriesSequences
- SourceMGI: 103582
The transcriptional landscape of the mammalian genome.
- CategoriesSequences
- SourceMGI: 103582
Severe growth retardation and short life span of double-mutant mice lacking Xpa and exon 15 of Xpg.
- Annotationdeficiency of exon 15 results in severe growth retardation and short life span
- CategoriesSequences, Phenotypes & Variants
Identification of the XPG region that causes the onset of Cockayne syndrome by using Xpg mutant mice generated by the cDNA-mediated knock-in method.
- AnnotationResults suggest that the Cockayne syndrome phenotype results from C-terminal truncations in the XPG (xeroderma pigmentosum) gene in mice and humans.
- CategoriesSequences, Phenotypes & Variants
Deficiency in the nuclease activity of xeroderma pigmentosum G in mice leads to hypersensitivity to UV irradiation.
- Annotationintroduced a point mutation into the XPG gene which inactivates the nuclease catalytic site but leaves the remainder of the protein intact. The mutant mice are hypersensitive to UV irradiation.
- CategoriesFunction, Phenotypes & Variants
- SourceGeneRif: 22592
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
- CategoriesPhenotypes & Variants
- SourceMGI: 103582
DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1.
- CategoriesExpression
- SourceMGI: 103582