E9QLQ9 · E9QLQ9_MOUSE
- ProteinAPC, WNT signaling pathway regulator
- GeneApc
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2808 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell periphery | |
Cellular Component | intracellular membrane-bounded organelle | |
Molecular Function | beta-catenin binding | |
Molecular Function | microtubule binding | |
Biological Process | negative regulation of Wnt signaling pathway | |
Biological Process | Wnt signaling pathway |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionE9QLQ9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for domain, coiled coil, region, compositional bias, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-55 | Adenomatous polyposis coli N-terminal dimerisation | ||||
Sequence: ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI | ||||||
Coiled coil | 6-54 | |||||
Sequence: YDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGS | ||||||
Coiled coil | 132-166 | |||||
Sequence: LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKR | ||||||
Region | 238-270 | Disordered | ||||
Sequence: AEAERSPATRVDHETASVLSSSGTHSAPRRLTS | ||||||
Compositional bias | 250-268 | Polar residues | ||||
Sequence: HETASVLSSSGTHSAPRRL | ||||||
Repeat | 624-666 | ARM | ||||
Sequence: NCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMG | ||||||
Region | 794-839 | Disordered | ||||
Sequence: VLPSSSSSRGSLDSSRSEKDRSLERERGIGLSAYHPTTENAGTSSK | ||||||
Compositional bias | 806-821 | Basic and acidic residues | ||||
Sequence: DSSRSEKDRSLERERG | ||||||
Region | 887-908 | Disordered | ||||
Sequence: RRSSASHTHSNTYNFTKSENSN | ||||||
Compositional bias | 890-908 | Polar residues | ||||
Sequence: SASHTHSNTYNFTKSENSN | ||||||
Compositional bias | 922-939 | Polar residues | ||||
Sequence: RSSNDSLNSVTSSDGYGK | ||||||
Region | 922-952 | Disordered | ||||
Sequence: RSSNDSLNSVTSSDGYGKRGQMKPSVESYSE | ||||||
Region | 1024-1045 | Disordered | ||||
Sequence: IKQNEQRQARSQNTSYPVYSEN | ||||||
Compositional bias | 1030-1044 | Polar residues | ||||
Sequence: RQARSQNTSYPVYSE | ||||||
Region | 1058-1134 | Disordered | ||||
Sequence: GQQECVSPYRSRGTSGSETNRMGSSHAINQNVNQSLCQEDDYEDDKPTNYSERYSEEEQHEEEEERPTNYSIKYNEE | ||||||
Compositional bias | 1064-1094 | Polar residues | ||||
Sequence: SPYRSRGTSGSETNRMGSSHAINQNVNQSLC | ||||||
Compositional bias | 1096-1113 | Basic and acidic residues | ||||
Sequence: EDDYEDDKPTNYSERYSE | ||||||
Region | 1155-1213 | Disordered | ||||
Sequence: SQKPSFSFSKNSSAQSTKPEHLSPSSENTAVPPSNAKRQNQLRPSSAQRNGQTQKGTTC | ||||||
Region | 1273-1341 | Disordered | ||||
Sequence: ENDVTRSAEDPATEVPAVSQNARAKPSRLQASGLSSESTRHNKAVEFSSGAKSPSKSGAQTPKSPPEHY | ||||||
Compositional bias | 1295-1339 | Polar residues | ||||
Sequence: RAKPSRLQASGLSSESTRHNKAVEFSSGAKSPSKSGAQTPKSPPE | ||||||
Region | 1366-1440 | Disordered | ||||
Sequence: IASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPQTVQAKREVPKSKVPAAEKRESGPKQTAVNAA | ||||||
Compositional bias | 1398-1412 | Pro residues | ||||
Sequence: PSRSKTPPPPPQTVQ | ||||||
Region | 1491-1534 | Disordered | ||||
Sequence: PPVQENDNGNETESEQPEESNENQDKEVEKPDSEKDLLDDSDDD | ||||||
Compositional bias | 1509-1525 | Basic and acidic residues | ||||
Sequence: ESNENQDKEVEKPDSEK | ||||||
Region | 1553-1572 | Disordered | ||||
Sequence: RKAKKLAQTASKLPPPVARK | ||||||
Compositional bias | 1712-1727 | Polar residues | ||||
Sequence: DQVQQASSTSSGANKN | ||||||
Region | 1712-1917 | Disordered | ||||
Sequence: DQVQQASSTSSGANKNQVDTKKKKPTSPVKPMPQNTEYRTRVRKNTDSKVNVNTEETFSDNKDSKKPSLQTNAKAFNEKLPNNEDRVRGSFALDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKGKESKDSEAKVTCRPEPNSSQQAASKSQASIKHPANRAQSKPVLQKQPTFPQSSKDGPDRGAATDEKLQN | ||||||
Compositional bias | 1751-1774 | Basic and acidic residues | ||||
Sequence: TRVRKNTDSKVNVNTEETFSDNKD | ||||||
Compositional bias | 1775-1789 | Polar residues | ||||
Sequence: SKKPSLQTNAKAFNE | ||||||
Compositional bias | 1827-1859 | Basic and acidic residues | ||||
Sequence: SSLDFDDDDVDLSREKAELRKGKESKDSEAKVT | ||||||
Compositional bias | 1860-1901 | Polar residues | ||||
Sequence: CRPEPNSSQQAASKSQASIKHPANRAQSKPVLQKQPTFPQSS | ||||||
Region | 1929-1976 | Disordered | ||||
Sequence: RNSSLSSLSDIDQENNNNKESEPIKEAEPANSQGEPSKPQASGYAPKS | ||||||
Region | 2008-2036 | Disordered | ||||
Sequence: ISSAMPKKKRPSRLKSESEKQSPRKVGGI | ||||||
Region | 2113-2618 | Disordered | ||||
Sequence: PFHLTPDQEEKPFTSNKGPRILKPGEKSTLEAKKIESENKGIKGGKKVYKSLITGKIRSNSEISSQMKQPLPTNMPSISRGRTMIHIPGLRNSSSSTSPVSKKGPPLKTPASKSPSEGPGATTSPRGTKPAGKSELSPITRQTSQISGSNKGSSRSGSRDSTPSRPTQQPLSRPMQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQLSQQNLTKQASLSKNASSIPRSESASKGLNQMSNGNGSNKKVELSRMSSTKSSGSESDRSERPALVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPDSPTRSQAQTPVLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYNDGRPTKRHDIARSHSESPSRLPINRAGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDERHVSSMPAPRQMKENQVPTKGTWRKIKESDISPTGMASQSASSGAASGAESKPLIYQMAPPVS | ||||||
Compositional bias | 2136-2157 | Basic and acidic residues | ||||
Sequence: PGEKSTLEAKKIESENKGIKGG | ||||||
Compositional bias | 2166-2192 | Polar residues | ||||
Sequence: TGKIRSNSEISSQMKQPLPTNMPSISR | ||||||
Domain | 2190-2541 | Adenomatous polyposis coli protein basic | ||||
Sequence: ISRGRTMIHIPGLRNSSSSTSPVSKKGPPLKTPASKSPSEGPGATTSPRGTKPAGKSELSPITRQTSQISGSNKGSSRSGSRDSTPSRPTQQPLSRPMQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQLSQQNLTKQASLSKNASSIPRSESASKGLNQMSNGNGSNKKVELSRMSSTKSSGSESDRSERPALVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPDSPTRSQAQTPVLSPSLPDMSLSTHPSVQAGGWRKLPPNLSPTIEYNDGRPTKRHDIARSHSESPSRLPINRAGTWKREHSKHSSSLPRVSTWRRTGSSSSILS | ||||||
Compositional bias | 2200-2215 | Polar residues | ||||
Sequence: PGLRNSSSSTSPVSKK | ||||||
Compositional bias | 2227-2392 | Polar residues | ||||
Sequence: PSEGPGATTSPRGTKPAGKSELSPITRQTSQISGSNKGSSRSGSRDSTPSRPTQQPLSRPMQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQLSQQNLTKQASLSKNASSIPRSESASKGLNQMSNGNGSNKKVELSRMSSTKSSG | ||||||
Compositional bias | 2427-2465 | Polar residues | ||||
Sequence: SFESLSPSSRPDSPTRSQAQTPVLSPSLPDMSLSTHPSV | ||||||
Compositional bias | 2485-2499 | Basic and acidic residues | ||||
Sequence: DGRPTKRHDIARSHS | ||||||
Compositional bias | 2523-2546 | Polar residues | ||||
Sequence: SLPRVSTWRRTGSSSSILSASSES | ||||||
Compositional bias | 2547-2562 | Basic and acidic residues | ||||
Sequence: SEKAKSEDERHVSSMP | ||||||
Compositional bias | 2587-2602 | Polar residues | ||||
Sequence: SPTGMASQSASSGAAS | ||||||
Region | 2630-2808 | Disordered | ||||
Sequence: CPINNPRSGRSPTGNTPPVIDSVSEKGSSSIKDSKDTHGKQSVGSGSPVQTVGLETRLNSFVQVEAPEQKGTEAKPGQSNPVSIAETAETCIAERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVSTNTKKRDSKTDSTESSGAQSPKRHSGSYLVTSV | ||||||
Compositional bias | 2635-2656 | Polar residues | ||||
Sequence: PRSGRSPTGNTPPVIDSVSEKG | ||||||
Domain | 2636-2808 | EB-1 binding | ||||
Sequence: RSGRSPTGNTPPVIDSVSEKGSSSIKDSKDTHGKQSVGSGSPVQTVGLETRLNSFVQVEAPEQKGTEAKPGQSNPVSIAETAETCIAERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVSTNTKKRDSKTDSTESSGAQSPKRHSGSYLVTSV | ||||||
Compositional bias | 2669-2695 | Polar residues | ||||
Sequence: KQSVGSGSPVQTVGLETRLNSFVQVEA | ||||||
Compositional bias | 2722-2778 | Polar residues | ||||
Sequence: AERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVSTNT | ||||||
Compositional bias | 2788-2808 | Polar residues | ||||
Sequence: TESSGAQSPKRHSGSYLVTSV |
Sequence similarities
Belongs to the adenomatous polyposis coli (APC) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,808
- Mass (Da)307,467
- Last updated2011-04-05 v1
- Checksum31158AD67B8E7186
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 250-268 | Polar residues | ||||
Sequence: HETASVLSSSGTHSAPRRL | ||||||
Compositional bias | 806-821 | Basic and acidic residues | ||||
Sequence: DSSRSEKDRSLERERG | ||||||
Compositional bias | 890-908 | Polar residues | ||||
Sequence: SASHTHSNTYNFTKSENSN | ||||||
Compositional bias | 922-939 | Polar residues | ||||
Sequence: RSSNDSLNSVTSSDGYGK | ||||||
Compositional bias | 1030-1044 | Polar residues | ||||
Sequence: RQARSQNTSYPVYSE | ||||||
Compositional bias | 1064-1094 | Polar residues | ||||
Sequence: SPYRSRGTSGSETNRMGSSHAINQNVNQSLC | ||||||
Compositional bias | 1096-1113 | Basic and acidic residues | ||||
Sequence: EDDYEDDKPTNYSERYSE | ||||||
Compositional bias | 1295-1339 | Polar residues | ||||
Sequence: RAKPSRLQASGLSSESTRHNKAVEFSSGAKSPSKSGAQTPKSPPE | ||||||
Compositional bias | 1398-1412 | Pro residues | ||||
Sequence: PSRSKTPPPPPQTVQ | ||||||
Compositional bias | 1509-1525 | Basic and acidic residues | ||||
Sequence: ESNENQDKEVEKPDSEK | ||||||
Compositional bias | 1712-1727 | Polar residues | ||||
Sequence: DQVQQASSTSSGANKN | ||||||
Compositional bias | 1751-1774 | Basic and acidic residues | ||||
Sequence: TRVRKNTDSKVNVNTEETFSDNKD | ||||||
Compositional bias | 1775-1789 | Polar residues | ||||
Sequence: SKKPSLQTNAKAFNE | ||||||
Compositional bias | 1827-1859 | Basic and acidic residues | ||||
Sequence: SSLDFDDDDVDLSREKAELRKGKESKDSEAKVT | ||||||
Compositional bias | 1860-1901 | Polar residues | ||||
Sequence: CRPEPNSSQQAASKSQASIKHPANRAQSKPVLQKQPTFPQSS | ||||||
Compositional bias | 2136-2157 | Basic and acidic residues | ||||
Sequence: PGEKSTLEAKKIESENKGIKGG | ||||||
Compositional bias | 2166-2192 | Polar residues | ||||
Sequence: TGKIRSNSEISSQMKQPLPTNMPSISR | ||||||
Compositional bias | 2200-2215 | Polar residues | ||||
Sequence: PGLRNSSSSTSPVSKK | ||||||
Compositional bias | 2227-2392 | Polar residues | ||||
Sequence: PSEGPGATTSPRGTKPAGKSELSPITRQTSQISGSNKGSSRSGSRDSTPSRPTQQPLSRPMQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQLSQQNLTKQASLSKNASSIPRSESASKGLNQMSNGNGSNKKVELSRMSSTKSSG | ||||||
Compositional bias | 2427-2465 | Polar residues | ||||
Sequence: SFESLSPSSRPDSPTRSQAQTPVLSPSLPDMSLSTHPSV | ||||||
Compositional bias | 2485-2499 | Basic and acidic residues | ||||
Sequence: DGRPTKRHDIARSHS | ||||||
Compositional bias | 2523-2546 | Polar residues | ||||
Sequence: SLPRVSTWRRTGSSSSILSASSES | ||||||
Compositional bias | 2547-2562 | Basic and acidic residues | ||||
Sequence: SEKAKSEDERHVSSMP | ||||||
Compositional bias | 2587-2602 | Polar residues | ||||
Sequence: SPTGMASQSASSGAAS | ||||||
Compositional bias | 2635-2656 | Polar residues | ||||
Sequence: PRSGRSPTGNTPPVIDSVSEKG | ||||||
Compositional bias | 2669-2695 | Polar residues | ||||
Sequence: KQSVGSGSPVQTVGLETRLNSFVQVEA | ||||||
Compositional bias | 2722-2778 | Polar residues | ||||
Sequence: AERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVSTNT | ||||||
Compositional bias | 2788-2808 | Polar residues | ||||
Sequence: TESSGAQSPKRHSGSYLVTSV |
Keywords
- Technical term