E9QHE3 · RN207_DANRE
- ProteinRING finger protein 207
- Genernf207b
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids634 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel kcnh6a/zerg, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | perinuclear region of cytoplasm | |
Molecular Function | Hsp70 protein binding | |
Molecular Function | transmembrane transporter binding | |
Molecular Function | zinc ion binding | |
Biological Process | cell-cell signaling involved in cardiac conduction | |
Biological Process | positive regulation of membrane repolarization during cardiac muscle cell action potential | |
Biological Process | positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential | |
Biological Process | regulation of cardiac muscle contraction | |
Biological Process | regulation of heart looping |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameRING finger protein 207
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionE9QHE3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Probably located in the endoplasmic reticulum and/or possibly the cis-Golgi apparatus.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Morpholino knockdown of the protein results in abnormal contractility and looping in developing heart. Morphants show prolonged duration of cardiac action potentials, occasional 2:1 atrioventricular block and slowed conduction velocity (PubMed:25281747).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000436857 | 1-634 | RING finger protein 207 | |||
Sequence: MSGEIFYSVDNLYDLDSANCHPLVCHLCQEQYEHPCLLDCYHTFCASCLRGRVADSRLTCPVCGHQSVVKGINALPPEDRLLKFLVDSSADSEETVQCANCDLECKKQDVDAMYYCNTCCQPLCRDCRETTHKAKMFSRHEIVSLAKRTKEAHKKCALHEEFYIMFSTEKKSMLCINCFRDMQVESRAHCIDIETAYIQGCEKLDQAVLAVKELQMSAREAIILLKAMIGEVRANVDEEESAICTLFSNMQEKLAERKKILLKAARSQHEEKERTFKEQLSHLAALLPTLQVHLVTCSAFLSSANKFEFLDMGYQLMERLKKIVKLPHRLRPTQSSKINTEYRSEFARCLEPLLLLGQRRSMSTTGSVALALGNASGLMQSSLSVQCHSPAMSDMSLCSSVVRRPTSHRYISTKVLLAKGGETPFMEHCCNYENSYRTLQTEIQKLKDQVQEIHRDLTKHHSLTKPDSMSEILEKSVQVDSQISSEYASVELMRAMFEEIWEETLQRVANEQEIYEAQLHDLLQLKQENSYLTTISRQIGPYIRSIAKVKERLEPRLKEPKELKDDRTEIMLKLYEDSTSTADTQPSNELSCNTEDNWTLNSLSEETNPKNKDYYRTNKQKNTTDSTNRKEIPM |
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for zinc finger, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 25-63 | RING-type | ||||
Sequence: CHLCQEQYEHPCLLDCYHTFCASCLRGRVADSRLTCPVC | ||||||
Zinc finger | 93-145 | B box-type; atypical | ||||
Sequence: EETVQCANCDLECKKQDVDAMYYCNTCCQPLCRDCRETTHKAKMFSRHEIVSL | ||||||
Compositional bias | 575-608 | Polar residues | ||||
Sequence: YEDSTSTADTQPSNELSCNTEDNWTLNSLSEETN | ||||||
Region | 575-634 | Disordered | ||||
Sequence: YEDSTSTADTQPSNELSCNTEDNWTLNSLSEETNPKNKDYYRTNKQKNTTDSTNRKEIPM | ||||||
Compositional bias | 609-634 | Basic and acidic residues | ||||
Sequence: PKNKDYYRTNKQKNTTDSTNRKEIPM |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length634
- Mass (Da)72,647
- Last updated2011-04-05 v1
- Checksum5402268D04426CE4
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M2B971 | A0A8M2B971_DANRE | rnf207b | 573 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 575-608 | Polar residues | ||||
Sequence: YEDSTSTADTQPSNELSCNTEDNWTLNSLSEETN | ||||||
Compositional bias | 609-634 | Basic and acidic residues | ||||
Sequence: PKNKDYYRTNKQKNTTDSTNRKEIPM |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR847529 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |