E9QE31 · E9QE31_DANRE
- ProteinCalpain-3
- Genecapn3b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids723 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Calcium-regulated non-lysosomal thiol-protease.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 120 | |||||
Sequence: C | ||||||
Active site | 277 | |||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleolus | |
Molecular Function | calcium ion binding | |
Molecular Function | calcium-dependent cysteine-type endopeptidase activity | |
Molecular Function | peptidase activity | |
Biological Process | calcium-dependent self proteolysis | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | protein catabolic process | |
Biological Process | proteolysis |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCalpain-3
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionE9QE31
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 65-360 | Calpain catalytic | ||||
Sequence: LFEDPLFPAQDSSLFYSEKFPLKLEWKRPMEICKNPQFILGGANRTDICQGDLGDCWLLAAIACLTLNDVILKRVVPHDQSFTENYAGIFHFQFWRYGEWVDVVIDDRLPTYKNKLVFTRSGQNNEFWSALMEKAYAKLHGSYEALKGGNSLEAMEDFTGGVTEFYEITEAPKELYNIMRKALKRGSLMGCAIDTLVPTAQRTKTASGLVRGHAYSVTGVEQGKRKDGKDLMIRLVRVRDPWGVAPPPACKSNDWVELAKTEQDKQRLQPGEQGEFWMCFEEFQKNFTKLEICNLT | ||||||
Domain | 624-659 | EF-hand | ||||
Sequence: NKIKQWKLVFTRFDTDKSSTISSFEMRNALTEAGFQ | ||||||
Domain | 689-723 | EF-hand | ||||
Sequence: VRLEGMFRAFRAFDKDGDGLIKLNVFEWLQLTMYA |
Sequence similarities
Belongs to the peptidase C2 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length723
- Mass (Da)83,174
- Last updated2016-01-20 v2
- Checksum2EEC5DEE1CB803C9
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9PSG7 | A0A8M9PSG7_DANRE | capn3b | 722 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL954831 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |