E9Q9R9 · DLG5_MOUSE

  • Protein
    Disks large homolog 5
  • Gene
    Dlg5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714).
Positively regulates the Hippo signaling by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (By similarity).
Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin (PubMed:25232112).
Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (PubMed:25644602).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentadherens junction
Cellular Componentcell junction
Cellular Componentciliary basal body
Cellular Componentcytoplasm
Cellular Componentglutamatergic synapse
Cellular Componentplasma membrane
Cellular Componentpostsynaptic density
Molecular Functionbeta-catenin binding
Molecular Functioncytoskeletal protein binding
Biological Processapical protein localization
Biological Processepithelial to mesenchymal transition
Biological Processepithelial tube branching involved in lung morphogenesis
Biological Processestablishment or maintenance of epithelial cell apical/basal polarity
Biological Processmaintenance of cell polarity
Biological Processmetanephric collecting duct development
Biological Processmidbrain development
Biological Processnegative regulation of cell migration
Biological Processnegative regulation of hippo signaling
Biological Processnegative regulation of T cell proliferation
Biological Processneuroepithelial cell differentiation
Biological Processpolarized epithelial cell differentiation
Biological Processpositive regulation of dendritic spine development
Biological Processpositive regulation of hippo signaling
Biological Processpositive regulation of smoothened signaling pathway
Biological Processpositive regulation of synapse assembly
Biological Processpostsynapse organization
Biological Processprotein localization to adherens junction
Biological Processprotein-containing complex assembly
Biological Processregulation of apoptotic process
Biological Processzonula adherens assembly

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Disks large homolog 5

Gene names

    • Name
      Dlg5

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    E9Q9R9
  • Secondary accessions
    • Q3UGX5

Proteomes

Organism-specific databases

Subcellular Location

Cell junction
Cell membrane
; Peripheral membrane protein
Postsynaptic density
Note: Localized at sites of cell-cell contact.

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant1642in allele LP; loss of neuronal function and disruption of interactions between the SH3 and guanylate kinase-like domains

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 108 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004405561-1921Disks large homolog 5
Modified residue264Phosphoserine
Modified residue295Phosphoserine
Modified residue900Phosphoserine
Modified residue984Phosphothreonine
Modified residue1000Phosphoserine
Modified residue1011Phosphothreonine
Modified residue1021Phosphoserine
Modified residue1183Phosphothreonine
Modified residue1209Phosphoserine
Modified residue1263Phosphoserine
Modified residue1334Phosphoserine
Modified residue1669Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Brain (at protein level).

Gene expression databases

Interaction

Subunit

Interacts with MPP1. Interacts with CTNNB1 and with the third SH3 domain of SORBS3 to form a ternary complex (By similarity).
Interacts (via coiled-coil domain) with MARK3. Interacts (via PDZ domain 3) with STK3/MST2 and STK4/MST1 (PubMed:28087714).
Interacts with SCRIB (By similarity).
Interacts with CTNB1 (PubMed:25232112).
Interacts with SMO and (via PDZ4 or guanylate kinase-like domain) with KIF7 (PubMed:25644602).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, coiled coil, compositional bias.

TypeIDPosition(s)Description
Domain1-90CARD
Region116-143Disordered
Coiled coil139-601
Domain620-710PDZ 1
Domain705-796PDZ 2
Region857-898Disordered
Compositional bias866-898Polar residues
Region930-1121Disordered
Compositional bias1045-1060Pro residues
Compositional bias1089-1112Basic and acidic residues
Region1204-1227Disordered
Region1243-1266Disordered
Region1280-1343Disordered
Compositional bias1290-1330Polar residues
Domain1350-1429PDZ 3
Compositional bias1434-1462Polar residues
Region1434-1501Disordered
Compositional bias1481-1496Polar residues
Domain1504-1585PDZ 4
Domain1596-1664SH3
Domain1724-1907Guanylate kinase-like

Domain

The guanylate kinase-like domain interacts with the SH3 domain.

Sequence similarities

Belongs to the MAGUK family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,921
  • Mass (Da)
    214,386
  • Last updated
    2011-04-05 v1
  • Checksum
    0B2C62F913B3B26E
MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQLDEEAGGAKAELLLQLLLAKEQDHFQDLRAALEKTQPHLLPILYLNGVVGPPQSTEGAGSTYSVLSIMPSDSESSSSLSSVGTTGKAPSPPPLLTEQQANDTVENLSIQLRLMTRERNELRKRLAFATHGATFDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEEVAKETDFYHTLHSRLLSDQTQLKDDVDMLRRENGKLRRERNLLQQSWEDMKRLREEDQKEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAMHNSDLSRLEQLGEENQRLQKQTEMLTQQRDTAIQLQHQCALSLRRFETIHHELSKATAQNKDLQWEMELLQSELTELRSKQVKTAKESEKYKEERDAVYSEYKLIMSERDQVISELDKLQTEVELAESKLKSSTSEKKAASEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQELKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLDDTRKQKNDVSRELKELKEQMECQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFERETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYAAAVVPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQSSSWSGQNIFENIKDSDRMLSCRAHGPEVQAHNKRNLLQHNNSTQTDIFYTDRLEDRKELGHSGGSSSFLHKPFSGSSSPVSPQACPSTSERSLNSFRSDTSAERGYGLVDMRSQRPLLSFETEVGPCGAVEVPLDKIDPEGSNSGGTWPKAVLGSTSGPEKLSVYKKPKQRKSIFDPNTFKRPQTPPKIDYLLPGPGLTHSPQPSKRVGSLTPPKPPRRSDSIKFQHRLETSSESEATLVGSSPSTSPPSAPPPSMDPSEPTHASPPRKARVRIASSYHSEGDGDTSYLPAKKPCDEDLTSQKVDELGQKRRRPKSAPSFRPKISPVVIPAQCLEEQECVPAIGELSPEGQEWSPYSPGHASRHGNPLLYPNRPSVGTVPRSMTPGTTVGSILRNPIYTVRSHRVLPCGSPPVPRDAGSQSLSPSVQHQGRLSLDLSHRACSDYSEMRASQGSNSLPSSARLGSSSNLQFKAERIKIPLTPRYPRSVMGSDRGSLSHSECSTPPRSPLNIDTLSSCSQPQTTASTLPRIAVNPSSHGERRKDRPFVEEPRHVKVQKGSEPLGISIVSGEKGGVYVSKVTLGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHIHQLNSHSRSSSHLDPAATPHSTLQGSSAGTPEHPSVIDPLMEQDEGPGTPPAKQSASSTRSVGDTTKKTPDPRIVFIKKSQLDLGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGSLDMRSRTVEDVYVEMLKPKDSLRLKVQYRHEEFTRVKGLPGDSFYIRALYDRLAEVEPELSFKKDDILYVDDTLPQGVFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMSEVKDDNTAKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDTFSNDSIPLFEDSVSLAYQRVQKVDCTSLRPVLLLGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIRYKSAKHIKEQRDPVYLRDKVTQRHSKEQFETAQKIDQEYSRYFTGVVQGGALSSICTQILAMVSQEQSKVLWIPACPP

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F6VMK9F6VMK9_MOUSEDlg5228
E9Q9I2E9Q9I2_MOUSEDlg51898
F6YZU5F6YZU5_MOUSEDlg51572
F6Z115F6Z115_MOUSEDlg5205
F7BYL0F7BYL0_MOUSEDlg572

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias866-898Polar residues
Sequence conflict946in Ref. 1; BAE28082
Compositional bias1045-1060Pro residues
Compositional bias1089-1112Basic and acidic residues
Compositional bias1290-1330Polar residues
Compositional bias1434-1462Polar residues
Compositional bias1481-1496Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK147699
EMBL· GenBank· DDBJ
BAE28082.1
EMBL· GenBank· DDBJ
mRNA
AC163638
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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