E9Q9M1 · E9Q9M1_MOUSE
- ProteinCytosolic purine 5'-nucleotidase
- GeneNt5c2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids586 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
Catalytic activity
- AMP + inosine = adenosine + IMP
- CMP + inosine = cytidine + IMP
- GMP + H2O = guanosine + phosphateThis reaction proceeds in the forward direction.
- GMP + inosine = guanosine + IMP
- H2O + XMP = phosphate + xanthosineThis reaction proceeds in the forward direction.
- dGMP + H2O = 2'-deoxyguanosine + phosphateThis reaction proceeds in the forward direction.
- dGMP + inosine = 2'-deoxyguanosine + IMP
- dIMP + H2O = 2'-deoxyinosine + phosphateThis reaction proceeds in the forward direction.
- dIMP + inosine = 2'-deoxyinosine + IMP
- inosine + UMP = IMP + uridine
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | identical protein binding | |
Molecular Function | IMP 5'-nucleotidase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleoside phosphotransferase activity | |
Molecular Function | ubiquitin protein ligase activity | |
Biological Process | allantoin metabolic process | |
Biological Process | dGMP metabolic process | |
Biological Process | GMP metabolic process | |
Biological Process | IMP catabolic process | |
Biological Process | negative regulation of defense response to virus by host | |
Biological Process | protein K48-linked ubiquitination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytosolic purine 5'-nucleotidase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionE9Q9M1
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Expression
Gene expression databases
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 567-586 | Disordered | ||||
Sequence: PQEITHCHDEDDDEEEEEEE |
Sequence similarities
Belongs to the 5'(3')-deoxyribonucleotidase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length586
- Mass (Da)67,704
- Last updated2011-04-05 v1
- Checksum0248FD77534B1883
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q3V1L4 | 5NTC_MOUSE | Nt5c2 | 560 | ||
A0A494B9X3 | A0A494B9X3_MOUSE | Nt5c2 | 585 | ||
A0A494BAN2 | A0A494BAN2_MOUSE | Nt5c2 | 78 | ||
A0A494BAU4 | A0A494BAU4_MOUSE | Nt5c2 | 62 | ||
A0A494BBK9 | A0A494BBK9_MOUSE | Nt5c2 | 59 | ||
A0A494BBP6 | A0A494BBP6_MOUSE | Nt5c2 | 528 | ||
A0A494BBM7 | A0A494BBM7_MOUSE | Nt5c2 | 97 | ||
A0A494BBI8 | A0A494BBI8_MOUSE | Nt5c2 | 87 | ||
G3X9J6 | G3X9J6_MOUSE | Nt5c2 | 251 |
Keywords
- Technical term