E9Q7X7 · NRX2A_MOUSE

  • Protein
    Neurexin-2
  • Gene
    Nrxn2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Features

Showing features for binding site.

117102004006008001,0001,2001,4001,600
TypeIDPosition(s)Description
Binding site335Ca2+ 1 (UniProtKB | ChEBI)
Binding site352Ca2+ 1 (UniProtKB | ChEBI)
Binding site420Ca2+ 1 (UniProtKB | ChEBI)
Binding site779Ca2+ 2 (UniProtKB | ChEBI)
Binding site796Ca2+ 2 (UniProtKB | ChEBI)
Binding site854Ca2+ 2 (UniProtKB | ChEBI)
Binding site1189Ca2+ 3 (UniProtKB | ChEBI)
Binding site1206Ca2+ 3 (UniProtKB | ChEBI)
Binding site1288Ca2+ 3 (UniProtKB | ChEBI)
Binding site1290Ca2+ 3 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell projection
Cellular Componentglutamatergic synapse
Cellular Componentpresynaptic membrane
Cellular Componentprotein-containing complex
Molecular Functioncalcium channel regulator activity
Molecular Functioncell adhesion molecule binding
Molecular Functionmetal ion binding
Molecular Functionneuroligin family protein binding
Molecular Functiontransmembrane signaling receptor activity
Biological Processadult behavior
Biological Processcell adhesion
Biological Processchemical synaptic transmission
Biological Processgephyrin clustering involved in postsynaptic density assembly
Biological Processneuroligin clustering involved in postsynaptic membrane assembly
Biological Processneurotransmitter secretion
Biological Processpostsynaptic density protein 95 clustering
Biological Processpostsynaptic membrane assembly
Biological Processpresynaptic modulation of chemical synaptic transmission
Biological Processregulation of postsynapse assembly
Biological Processsignal transduction
Biological Processsocial behavior
Biological Processsynapse assembly
Biological Processvocal learning
Biological Processvocalization behavior

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Neurexin-2
  • Alternative names
    • Neurexin II-alpha
    • Neurexin-2-alpha

Gene names

    • Name
      Nrxn2

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    E9Q7X7

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain29-1634Extracellular
Transmembrane1635-1655Helical
Topological domain1656-1710Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-28
ChainPRO_500324449229-1710Neurexin-2
Glycosylation60N-linked (GlcNAc...) asparagine
Disulfide bond206↔219
Disulfide bond213↔229
Disulfide bond231↔241
Glycosylation338N-linked (GlcNAc...) asparagine
Disulfide bond450↔486
Disulfide bond657↔686
Disulfide bond694↔705
Disulfide bond699↔714
Disulfide bond716↔726
Glycosylation841N-linked (GlcNAc...) asparagine
Disulfide bond1065↔1093
Disulfide bond1100↔1111
Disulfide bond1105↔1120
Disulfide bond1122↔1132
Glycosylation1400O-linked (Xyl...) (heparan sulfate) serine

Post-translational modification

O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

The laminin G-like domain 1 binds to NXPH1. Interacts with PATJ (By similarity).
Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (PubMed:21410790, PubMed:22220752).
Specific isoforms bind neuroligins NLGN1, NLGN2 and NLGN3 (By similarity).
Specific isoforms bind to alpha-dystroglycan (By similarity).
Interacts (via Laminin G-like 1 domain) with IGSF21 (Ig-like 1 domain) in a trans-interaction manner (PubMed:28864826).
Interacts with CLSTN3 (PubMed:24094106, PubMed:24613359, PubMed:32434929).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain29-206Laminin G-like 1
Domain202-242EGF-like 1
Domain289-486Laminin G-like 2
Domain493-686Laminin G-like 3
Domain690-727EGF-like 2
Domain732-904Laminin G-like 4
Domain918-1093Laminin G-like 5
Domain1096-1133EGF-like 3
Domain1137-1345Laminin G-like 6
Region1458-1508Disordered
Region1587-1621Disordered
Region1677-1710Disordered
Compositional bias1694-1710Basic and acidic residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 2 isoforms produced by Alternative promoter usage. A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus.

E9Q7X7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,710
  • Mass (Da)
    184,885
  • Last updated
    2011-04-05 v1
  • Checksum
    FB3DB56946383587
MALGSRWQPPPQLPPLLLLLALAAGVRGLEFGGGPGQWARYARWAGAASTGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGAAADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGAGVGSHSSTQRADYFAMELLDGYLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGESEVLDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGICREGWNRFVCDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPTAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMRLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHTRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTMRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPSSGGPCQAERDDSDCEEPVEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGVPTAFEPRRPPPLRPGVTSAPGFPRLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV

E9PUN2-1

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F6Y027F6Y027_MOUSENrxn2216
E9Q5N7E9Q5N7_MOUSENrxn21503
E9PUM9E9PUM9_MOUSENrxn21703
E9PUN0E9PUN0_MOUSENrxn21640
E9PUN1E9PUN1_MOUSENrxn2353
E9PUN2NRX2B_MOUSENrxn2660
A0A494B8Y4A0A494B8Y4_MOUSENrxn21511

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1694-1710Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC124394
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC167245
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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