E9Q7C7 · E9Q7C7_MOUSE
- ProteinFibroblast growth factor receptor
- GeneFgfr2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids726 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 392-398 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LGEGCFG | ||||||
Binding site | 422 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 470-472 | ATP (UniProtKB | ChEBI) | ||||
Sequence: EYA | ||||||
Binding site | 476 | ATP (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Active site | 531 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 535 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 549 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Golgi apparatus | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | fibroblast growth factor receptor activity | |
Biological Process | positive regulation of cell population proliferation | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFibroblast growth factor receptor
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionE9Q7C7
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-40 | Helical | ||||
Sequence: MVSWGRFICLVLVTMATLSLA | ||||||
Transmembrane | 280-302 | Helical | ||||
Sequence: YLEIAIYCIGVFLIACMVVTVIF |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 83↔135 | |||||
Sequence: CPAGGNPTPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTC | ||||||
Disulfide bond | 182↔244 | |||||
Sequence: CKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEMDAGEYIC |
Keywords
- PTM
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 42-151 | Ig-like | ||||
Sequence: PSFSLVEDTTLEPEGAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPTPTMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCLVENEYGSINHTYHLD | ||||||
Domain | 160-260 | Ig-like | ||||
Sequence: PILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGINSSNAEVLALFNVTEMDAGEYICKVSNYIGQANQSAWLT | ||||||
Domain | 386-675 | Protein kinase | ||||
Sequence: LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYL |
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length726
- Mass (Da)81,644
- Last updated2011-04-05 v1
- Checksum620C7DCB586B1D29
Computationally mapped potential isoform sequences
There are 19 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P21803 | FGFR2_MOUSE | Fgfr2 | 821 | ||
E9PXV8 | E9PXV8_MOUSE | Fgfr2 | 724 | ||
F7BDU9 | F7BDU9_MOUSE | Fgfr2 | 61 | ||
E9Q7T0 | E9Q7T0_MOUSE | Fgfr2 | 819 | ||
E9PVU6 | E9PVU6_MOUSE | Fgfr2 | 820 | ||
E9PX60 | E9PX60_MOUSE | Fgfr2 | 695 | ||
E9PX67 | E9PX67_MOUSE | Fgfr2 | 813 | ||
E9PX88 | E9PX88_MOUSE | Fgfr2 | 698 | ||
E9PX90 | E9PX90_MOUSE | Fgfr2 | 705 | ||
E9Q700 | E9Q700_MOUSE | Fgfr2 | 609 | ||
E9Q708 | E9Q708_MOUSE | Fgfr2 | 731 | ||
E9Q7E8 | E9Q7E8_MOUSE | Fgfr2 | 822 | ||
E9Q7E6 | E9Q7E6_MOUSE | Fgfr2 | 608 | ||
E9Q5C2 | E9Q5C2_MOUSE | Fgfr2 | 723 | ||
E9Q5C3 | E9Q5C3_MOUSE | Fgfr2 | 696 | ||
D3Z5M8 | D3Z5M8_MOUSE | Fgfr2 | 709 | ||
D6RJK5 | D6RJK5_MOUSE | Fgfr2 | 334 | ||
E9QK53 | E9QK53_MOUSE | Fgfr2 | 840 | ||
F2Z480 | F2Z480_MOUSE | Fgfr2 | 182 |
Keywords
- Technical term