Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L.[...], Ponting C.P.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCPLoS Biol. 7:E1000112-E1000112 (2009)Cited in99+99+
The transcriptional landscape of the mammalian genome.Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B.[...], Hayashizaki Y.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 921-1054StrainC57BL/6JTissueLiverCategorySequencesSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCScience 309:1559-1563 (2005)Cited in99+16Mapped to99+
NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity.Arthur J.C., Lich J.D., Ye Z., Allen I.C., Gris D., Wilson J.E., Schneider M., Roney K.E., O'Connor B.P.[...], Ting J.P.View abstractCited forFUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPECategoriesFunction, Expression, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Immunol. 185:4515-4519 (2010)Cited in1Mapped to6
The nod-like receptor, Nlrp12, plays an anti-inflammatory role in experimental autoimmune encephalomyelitis.Gharagozloo M., Mahvelati T.M., Imbeault E., Gris P., Zerif E., Bobbala D., Ilangumaran S., Amrani A., Gris D.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCJ. Neuroinflamm. 12:198-198 (2015)Cited in1Mapped to4
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens.Normand S., Waldschmitt N., Neerincx A., Martinez-Torres R.J., Chauvin C., Couturier-Maillard A., Boulard O., Cobret L., Awad F.[...], Chamaillard M.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCNat. Commun. 9:5338-5338 (2018)Cited in4Mapped to25
The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis.Truax A.D., Chen L., Tam J.W., Cheng N., Guo H., Koblansky A.A., Chou W.C., Wilson J.E., Brickey W.J.[...], Ting J.P.View abstractCited forFUNCTION, DISRUPTION PHENOTYPECategoriesFunction, Phenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Host Microbe 24:364-378 (2018)Cited in1Mapped to6
NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25.Chen S.T., Chen L., Lin D.S., Chen S.Y., Tsao Y.P., Guo H., Li F.J., Tseng W.T., Tam J.W.[...], Ting J.P.View abstractCited forDISRUPTION PHENOTYPECategoryPhenotypes & VariantsSourceUniProtKB reviewed (Swiss-Prot)PubMedEurope PMCCell Host Microbe 0:0-0 (2019)Cited in3Mapped to24
Overexpression of NLRP12 enhances macrophage immune response and alleviates herpes simplex keratitis.Jiang J., Zhang D., Liu W., Yang J., Yang F., Liu J., Hu K.View abstractAnnotationOverexpression of NLRP12 enhances macrophage immune response and alleviates herpes simplex keratitis.CategoryFunctionSourceGeneRif: 378425PubMedEurope PMCFront Cell Infect Microbiol 14:1416105-1416105 (2024)Mapped to5
Movement-related increases in subthalamic activity optimize locomotion.Callahan J.W., Morales J.C., Atherton J.F., Wang D., Kostic S., Bevan M.D.View abstractSourceMGI: 2676630PubMedEurope PMCCell Rep 43:114495-114495 (2024)Mapped to99+
Overexpression of NLRP12 enhances antiviral immunity and alleviates herpes simplex keratitis via pyroptosis/IL-18/IFN-gamma signaling.Jiang J., Shen W., He Y., Liu J., Ouyang J., Zhang C., Hu K.View abstractAnnotationOverexpression of NLRP12 enhances antiviral immunity and alleviates herpes simplex keratitis via pyroptosis/IL-18/IFN-gamma signaling.CategoryFunctionSourceGeneRif: 378425PubMedEurope PMCInt Immunopharmacol 137:112428-112428 (2024)Mapped to5
Anti-hyperalgesic and anti-inflammatory effects of 4R-tobacco cembranoid in a mouse model of inflammatory pain.Rivera-Garcia L.G., Francis-Malave A.M., Castillo Z.W., Uong C.D., Wilson T.D., Ferchmin P.A., Eterovic V., Burton M.D., Carrasquillo Y.View abstractCategoryFunctionSourceMGI: 2676630PubMedEurope PMCJ Inflamm (Lond) 21:2-2 (2024)Mapped to28
NLRP12 Senses the SARS-CoV-2 Membrane Protein and Promotes an Inflammatory Response.Li X., Zhou G., Sun X., Qu S., Lai H., Wu Y., Li D., Liu L., Zhang G.[...], Huang X.View abstractAnnotationNLRP12 Senses the SARS-CoV-2 Membrane Protein and Promotes an Inflammatory Response.CategoryFunctionSourceGeneRif: 378425PubMedEurope PMCJ Infect Dis 229:660-670 (2024)Mapped to5
ERG K<sup>+</sup> channels mediate a major component of action potential repolarization in lymphatic muscle.Kim H.J., Li M., Erlich E.C., Randolph G.J., Davis M.J.View abstractSourceMGI: 2676630PubMedEurope PMCSci Rep 13:14890-14890 (2023)Mapped to99+
NLRP12 downregulates the Wnt/beta-catenin pathway via interaction with STK38 to suppress colorectal cancer.Khan S., Kwak Y.T., Peng L., Hu S., Cantarel B.L., Lewis C.M., Gao Y., Mani R.S., Kanneganti T.D., Zaki H.View abstractAnnotationNLRP12 downregulates the Wnt/beta-catenin pathway via interaction with STK38 to suppress colorectal cancer.CategoryFunctionSourceGeneRif: 378425, MGI: 2676630PubMedEurope PMCJ Clin Invest 133:e166295-e166295 (2023)Mapped to5
Hdac1 and Hdac2 regulate the quiescent state and survival of hair-follicle mesenchymal niche.Sibony-Benyamini H., Aamar E., Enshell-Seijffers D.View abstractSourceMGI: 2676630PubMedEurope PMCNat Commun 14:4820-4820 (2023)Mapped to38
Immune regulator IRF1 contributes to ZBP1-, AIM2-, RIPK1-, and NLRP12- PANoptosome activation and inflammatory cell death (PANoptosis).Sharma B.R., Karki R., Rajesh Y., Kanneganti T.D.View abstractAnnotationImmune regulator IRF1 contributes to ZBP1- AIM2- RIPK1- and NLRP12-PANoptosome activation and inflammatory cell death (PANoptosis).CategoryFunctionSourceGeneRif: 378425PubMedEurope PMCJ Biol Chem 299:105141-105141 (2023)Mapped to14
<i>Nlrp12</i> deficiency alters gut microbiota and ameliorates <i>Fas<sup>lpr</sup></i> -mediated systemic autoimmunity in male mice.Abdelhamid L., Mao J., Cabana-Puig X., Zhu J., Swartwout B.K., Edwards M.R., Testerman J.C., Michaelis J.S., Allen I.C.[...], Luo X.M.View abstractAnnotationNlrp12 deficiency alters gut microbiota and ameliorates Fas[lpr]CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 378425, MGI: 2676630PubMedEurope PMCFront Immunol 14:1120958-1120958 (2023)Mapped to10
The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation.Merchak A.R., Cahill H.J., Brown L.C., Brown R.M., Rivet-Noor C., Beiter R.M., Slogar E.R., Olgun D.G., Gaultier A.View abstractSourceMGI: 2676630PubMedEurope PMCPLoS Biol 21:e3002000-e3002000 (2023)Mapped to99+
Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst.Tomlinson K.L., Riquelme S.A., Baskota S.U., Drikic M., Monk I.R., Stinear T.P., Lewis I.A., Prince A.S.View abstractSourceMGI: 2676630PubMedEurope PMCCell Rep 42:112064-112064 (2023)Mapped to30
NLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression.Tsao Y.P., Tseng F.Y., Chao C.W., Chen M.H., Yeh Y.C., Abdulkareem B.O., Chen S.Y., Chuang W.T., Chang P.C.[...], Chen S.T.View abstractAnnotationNLRP12 is an innate immune checkpoint for repressing IFN signatures and attenuating lupus nephritis progression.CategoriesFunction, ExpressionSourceGeneRif: 378425PubMedEurope PMCJ Clin Invest 133:e157272-e157272 (2023)Mapped to5
The innate immune receptor Nlrp12 suppresses autoimmunity to the retina.Lee E.J., Napier R.J., Vance E.E., Lashley S.J., Truax A.D., Ting J.P., Rosenzweig H.L.View abstractAnnotationThe innate immune receptor Nlrp12 suppresses autoimmunity to the retina.CategoriesFunction, Phenotypes & VariantsSourceGeneRif: 378425, MGI: 2676630PubMedEurope PMCJ Neuroinflammation 19:69-69 (2022)Mapped to8
TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease.Seo B.A., Kim D., Hwang H., Kim M.S., Ma S.X., Kwon S.H., Kweon S.H., Wang H., Yoo J.M.[...], Ko H.S.View abstractSourceMGI: 2676630PubMedEurope PMCNeuron 109:3758-3774.e11 (2021)Mapped to99+
The bone microenvironment invigorates metastatic seeds for further dissemination.Zhang W., Bado I.L., Hu J., Wan Y.W., Wu L., Wang H., Gao Y., Jeong H.H., Xu Z.[...], Zhang X.H.View abstractSourceMGI: 2676630PubMedEurope PMCCell 184:2471-2486.e20 (2021)Mapped to99+
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species.Moustaqil M., Ollivier E., Chiu H.P., Van Tol S., Rudolffi-Soto P., Stevens C., Bhumkar A., Hunter D.J.B., Freiberg A.N.[...], Gambin Y.View abstractCategoriesFunction, PTM / ProcessingSourceMGI: 2676630PubMedEurope PMCEmerg Microbes Infect 10:178-195 (2021)Mapped to8
NLRP12 negatively regulates EtOH-induced liver macrophage activation via NF-kappaB pathway and mediates hepatocyte apoptosis in alcoholic liver injury.Zhang Y.F., Bu F.T., Yin N.N., Wang A., You H.M., Wang L., Jia W.Q., Huang C., Li J.View abstractAnnotationNLRP12 negatively regulates EtOH-induced liver macrophage activation via NF-kappaB pathway and mediates hepatocyte apoptosis in alcoholic liver injury.CategoryFunctionSourceGeneRif: 378425PubMedEurope PMCInt Immunopharmacol 88:106968-106968 (2020)Mapped to5