E9Q559 · E9Q559_MOUSE
- ProteinCalcium-transporting ATPase
- GeneAtp2a3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1026 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the hydrolysis of ATP coupled with the transport of calcium.
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Catalytic activity
- ATP + Ca2+(in) + H2O = ADP + Ca2+(out) + H+ + phosphateThis reaction proceeds in the forward direction.
CHEBI:30616 + Ca2+ (in)CHEBI:29108+ CHEBI:15377 = CHEBI:456216 + Ca2+ (out)CHEBI:29108+ CHEBI:15378 + CHEBI:43474
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | sarcoplasmic reticulum membrane | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | P-type calcium transporter activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCalcium-transporting ATPase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionE9Q559
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Sarcoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 60-78 | Helical | ||||
Sequence: LLVRILLLAALVSFVLAWF | ||||||
Transmembrane | 84-107 | Helical | ||||
Sequence: TTTAFVEPLVIMLILVANAIVGVW | ||||||
Transmembrane | 260-280 | Helical | ||||
Sequence: LSHAISVICVAVWVINIGHFA | ||||||
Transmembrane | 292-321 | Helical | ||||
Sequence: AVYYFKIAVALAVAAIPEGLPAVITTCLAL | ||||||
Transmembrane | 760-781 | Helical | ||||
Sequence: FIRYLISSNVGEVVCIFLTAIL | ||||||
Transmembrane | 833-857 | Helical | ||||
Sequence: LFFRYLAIGVYVGLATVAAATWWFL | ||||||
Transmembrane | 932-957 | Helical | ||||
Sequence: WLLGAVVMSMALHFLILLVPPLPLIF |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-77 | Cation-transporting P-type ATPase N-terminal | ||||
Sequence: EAHLLSAADVLRRFSVTAEGGLSLEQVTDARERYGPNELPTEEGKSLWELVVEQFEDLLVRILLLAALVSFVLAW | ||||||
Region | 1007-1026 | Disordered | ||||
Sequence: LPTTSRTPYHTGLASWKKRT |
Sequence similarities
Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,026
- Mass (Da)112,504
- Last updated2011-04-05 v1
- ChecksumE8EC0928C4E8F278
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Keywords
- Technical term