E9Q3X6 · E9Q3X6_MOUSE
- ProteinAmine oxidase
- GeneMaob
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids211 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially degrades benzylamine and phenylethylamine.
Catalytic activity
- (R)-adrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + methylamine + H2O2
- (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4+
- 2-phenylethylamine + O2 + H2O = 2-phenylacetaldehyde + H2O2 + NH4+
- N-acetylputrescine + O2 + H2O = 4-acetamidobutanal + H2O2 + NH4+This reaction proceeds in the forward direction.
- tyramine + O2 + H2O = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4+
- benzylamine + O2 + H2O = benzaldehyde + H2O2 + NH4+This reaction proceeds in the forward direction.
- dopamine + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4+
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial outer membrane | |
Molecular Function | monoamine oxidase activity | |
Molecular Function | primary methylamine oxidase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAmine oxidase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionE9Q3X6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion outer membrane ; Single-pass type IV membrane protein
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.
Structure
Sequence
- Sequence statusComplete
- Length211
- Mass (Da)23,678
- Last updated2011-04-05 v1
- ChecksumCC0DA82C9B7A52E5
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Keywords
- Technical term