E9Q1R5 · E9Q1R5_MOUSE
- ProteinVoltage-dependent P/Q-type calcium channel subunit alpha
- GeneCacna1a
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids2321 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents.
Catalytic activity
- Ca2+(in) = Ca2+(out)
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | voltage-gated calcium channel complex | |
Molecular Function | metal ion binding | |
Molecular Function | voltage-gated calcium channel activity |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent P/Q-type calcium channel subunit alpha
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionE9Q1R5
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 94-114 | Helical | ||||
Sequence: YFIGIFCFEAGIKIVALGFAF | ||||||
Transmembrane | 126-144 | Helical | ||||
Sequence: VMDFVVVLTGILATVGTEF | ||||||
Transmembrane | 177-200 | Helical | ||||
Sequence: AMIPLLQIGLLLFFAILIFAIIGL | ||||||
Transmembrane | 259-280 | Helical | ||||
Sequence: ILFAVLTVFQCITMEGWTDLLY | ||||||
Transmembrane | 292-314 | Helical | ||||
Sequence: WLYFIPLIIIGSFFMLNLVLGVL | ||||||
Transmembrane | 443-462 | Helical | ||||
Sequence: AFYWTVLSLVALNTLCVAIV | ||||||
Transmembrane | 474-494 | Helical | ||||
Sequence: LYYAEFIFLGLFMSEMFIKMY | ||||||
Transmembrane | 569-591 | Helical | ||||
Sequence: IISLLFLLFLFIVVFALLGMQLF | ||||||
Transmembrane | 645-669 | Helical | ||||
Sequence: FSIYFIVLTLFGNYTLLNVFLAIAV | ||||||
Transmembrane | 1147-1166 | Helical | ||||
Sequence: LRYFEMCILMVIAMSSIALA | ||||||
Transmembrane | 1186-1207 | Helical | ||||
Sequence: YVFTGVFTFEMVIKMIDLGLVL | ||||||
Transmembrane | 1219-1236 | Helical | ||||
Sequence: ILDFIVVSGALVAFAFTG | ||||||
Transmembrane | 1281-1303 | Helical | ||||
Sequence: VFNILIVYMLFMFIFAVVAVQLF | ||||||
Transmembrane | 1393-1418 | Helical | ||||
Sequence: IFYVVYFVVFPFFFVNIFVALIIITF | ||||||
Transmembrane | 1474-1492 | Helical | ||||
Sequence: YTIMAMIALNTIVLMMKFY | ||||||
Transmembrane | 1504-1527 | Helical | ||||
Sequence: VFNIVFTSLFSLECVLKVMAFGIL | ||||||
Transmembrane | 1595-1613 | Helical | ||||
Sequence: ALPYVCLLIAMLFFIYAII | ||||||
Transmembrane | 1691-1715 | Helical | ||||
Sequence: AYFYFVSFIFLCSFLMLNLFVAVIM |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Glycosylation | 238 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for coiled coil, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 665-701 | |||||
Sequence: LAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEV | ||||||
Region | 715-734 | Disordered | ||||
Sequence: AVKEQQKNQKPTKSVWEQRT | ||||||
Region | 776-1070 | Disordered | ||||
Sequence: PLVVDPQENRNNNTNKSRAPEALRPTARPRESARDPDARRAWPGSPERAPGREGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPE | ||||||
Compositional bias | 781-795 | Polar residues | ||||
Sequence: PQENRNNNTNKSRAP | ||||||
Compositional bias | 798-817 | Basic and acidic residues | ||||
Sequence: LRPTARPRESARDPDARRAW | ||||||
Compositional bias | 827-944 | Basic and acidic residues | ||||
Sequence: REGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQ | ||||||
Compositional bias | 947-964 | Polar residues | ||||
Sequence: GVPVSGPNLSTTRPIQQD | ||||||
Compositional bias | 1005-1034 | Polar residues | ||||
Sequence: PAKIGNSTNPGPALATNPQNAASRRTPNNP | ||||||
Compositional bias | 1045-1065 | Polar residues | ||||
Sequence: TPENSLIVTNPSSTQPNSAKT | ||||||
Region | 1090-1124 | Disordered | ||||
Sequence: VNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPP | ||||||
Compositional bias | 1097-1117 | Basic and acidic residues | ||||
Sequence: DPLPKKEEEKKEEEEADPGED | ||||||
Domain | 1852-1886 | Voltage-dependent calcium channel alpha-1 subunit IQ | ||||
Sequence: STDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQN | ||||||
Region | 1893-2321 | Disordered | ||||
Sequence: QRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAHEGGMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNDLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTPRPLVSYSPAPRRPAARRMAGPAAPPGGSPRGCRRAPRWPAHAPEGPRPRGADYTEPDSPREPPGGAHDPAPRSPRTPRAAGCASPRHGRRLPNGYYAGHGAPRPRTARRGAHDAYSESEDDWC | ||||||
Compositional bias | 1900-1915 | Polar residues | ||||
Sequence: PTQEGGPSQNALPSTQ | ||||||
Compositional bias | 1934-1948 | Polar residues | ||||
Sequence: SWVTQRAQEMFQKTG | ||||||
Compositional bias | 1960-1974 | Polar residues | ||||
Sequence: MPNSQPNSQSVEMRE | ||||||
Compositional bias | 2039-2058 | Basic and acidic residues | ||||
Sequence: RLDDYSLERVPPEENQRYHQ | ||||||
Compositional bias | 2109-2126 | Basic residues | ||||
Sequence: DRKHRPHHHHHHHHHHPP | ||||||
Compositional bias | 2127-2163 | Basic and acidic residues | ||||
Sequence: APDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTH | ||||||
Compositional bias | 2164-2198 | Polar residues | ||||
Sequence: RQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTP | ||||||
Compositional bias | 2304-2321 | Basic and acidic residues | ||||
Sequence: TARRGAHDAYSESEDDWC |
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1A subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,321
- Mass (Da)262,163
- Last updated2011-04-05 v1
- Checksum80712954B0C225AC
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
P97445 | CAC1A_MOUSE | Cacna1a | 2368 | ||
A0A571BE75 | A0A571BE75_MOUSE | Cacna1a | 183 | ||
A0A571BET0 | A0A571BET0_MOUSE | Cacna1a | 2457 | ||
A0A571BEF0 | A0A571BEF0_MOUSE | Cacna1a | 776 | ||
A0A1L1SQZ2 | A0A1L1SQZ2_MOUSE | Cacna1a | 2321 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 781-795 | Polar residues | ||||
Sequence: PQENRNNNTNKSRAP | ||||||
Compositional bias | 798-817 | Basic and acidic residues | ||||
Sequence: LRPTARPRESARDPDARRAW | ||||||
Compositional bias | 827-944 | Basic and acidic residues | ||||
Sequence: REGPYGRESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQ | ||||||
Compositional bias | 947-964 | Polar residues | ||||
Sequence: GVPVSGPNLSTTRPIQQD | ||||||
Compositional bias | 1005-1034 | Polar residues | ||||
Sequence: PAKIGNSTNPGPALATNPQNAASRRTPNNP | ||||||
Compositional bias | 1045-1065 | Polar residues | ||||
Sequence: TPENSLIVTNPSSTQPNSAKT | ||||||
Compositional bias | 1097-1117 | Basic and acidic residues | ||||
Sequence: DPLPKKEEEKKEEEEADPGED | ||||||
Compositional bias | 1900-1915 | Polar residues | ||||
Sequence: PTQEGGPSQNALPSTQ | ||||||
Compositional bias | 1934-1948 | Polar residues | ||||
Sequence: SWVTQRAQEMFQKTG | ||||||
Compositional bias | 1960-1974 | Polar residues | ||||
Sequence: MPNSQPNSQSVEMRE | ||||||
Compositional bias | 2039-2058 | Basic and acidic residues | ||||
Sequence: RLDDYSLERVPPEENQRYHQ | ||||||
Compositional bias | 2109-2126 | Basic residues | ||||
Sequence: DRKHRPHHHHHHHHHHPP | ||||||
Compositional bias | 2127-2163 | Basic and acidic residues | ||||
Sequence: APDRDRYAQERPDTGRARAREQRWSRSPSEGREHTTH | ||||||
Compositional bias | 2164-2198 | Polar residues | ||||
Sequence: RQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPCTP | ||||||
Compositional bias | 2304-2321 | Basic and acidic residues | ||||
Sequence: TARRGAHDAYSESEDDWC |
Keywords
- Technical term