combination antiretroviral therapy increased monocyte/macrophage sensitivity to reactive oxygen species- in HIV(+) individuals by suppressing NRF2-ARE activity via p90RSK-mediated ERK5 S496 phosphorylation which coordinately elicited senescent phenotypes and proinflammatory responses
In hippocampal neurons of wild-type mice pP90RSK translocates into the nucleus upon stimulation with forskolin (left) whereas in Period1-knockout (Per1(-/-) ) mice (right) the kinase is trapped at the nuclear periphery
Data show that the phosphoinositide-dependent kinase 1 (PDK1)-p90 kDa ribosomal S6 kinases (Rsks) Rsk1/2 pathway is critical for establishment and maintenance of a normal Langerhans cells (LC) network.
IL-6 induces the activation of the Stat3 signaling and promotes the downmodulation of the p90RSK/eEF2 and mTOR/p70S6K axes while it does not affect the activation of AKT.
These data indicate that aripiprazole and quetiapine signal to specific nuclear targets of ERK which for quetiapine occurs via an EGFR-linked mechanism possibly indicating involvement of this system in its action.
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