E9PUN6 · E9PUN6_MOUSE
- ProteinADAM metallopeptidase with thrombospondin type 1 motif 9
- GeneAdamts9
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1931 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 223 | Zn2+ (UniProtKB | ChEBI); catalytic; in inhibited form | ||||
Sequence: C | ||||||
Binding site | 296 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 296 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 383 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 434 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Active site | 435 | |||||
Sequence: E | ||||||
Binding site | 438 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 444 | Zn2+ (UniProtKB | ChEBI); catalytic | ||||
Sequence: H | ||||||
Binding site | 494 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | extracellular matrix | |
Cellular Component | extracellular space | |
Molecular Function | endopeptidase activity | |
Molecular Function | metalloendopeptidase activity | |
Molecular Function | metallopeptidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | camera-type eye morphogenesis | |
Biological Process | cornea development in camera-type eye | |
Biological Process | extracellular matrix organization | |
Biological Process | lens development in camera-type eye | |
Biological Process | melanocyte differentiation | |
Biological Process | positive regulation of melanocyte differentiation | |
Biological Process | proteolysis | |
Biological Process | regulation of developmental pigmentation | |
Biological Process | response to bacterium |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionE9PUN6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-20 | |||||
Sequence: MQLVSWATLLTLLVPDLVEM | ||||||
Chain | PRO_5003244244 | 21-1931 | ||||
Sequence: RSPDSAAAVRKDRLHPRQVKLLESLSEYEIASPIRVNPLGEPFPTNVHFKRRRRSINSASDPWPAFASSSSSSTSSQEHYRLSAFGQQFLFNLTAHTGFIAPLFTVTLLGEPGVNQTKLYSEEEMELRHCFYKGHVNTKSEHTAVISLCSGMMGTFRSHDGDYFIEPLQSVDEQEDEEEQNKPHIIYRHSTPQREPSTGKHACATSELKNSHSKDKRKIRMRKRRKRNSLADDVALLKSGLATKVLSGYSNQTNSTRDRWNHKRTKRFLSYPRFVEVMVVADHRMVLYHGANLQHYILTLMSIVASIYKDSSIGNLINIVIVNLVVIHNEQEGPYINFNAQTTLKNFCQWQHSKNYLGGIQHDTAVLVTREDICRAQDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDSNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPASRTYPLPSQLPGLLYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVDGAHKGCRTQHTPWADGTECEPGKHCKFGFCVPKEMEGPAIDGSWGGWSHFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCMKQKRDFREEQCAHFDGKHFNINGLLPSVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHILNSKARKDKCGICGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATSIDVRQHSFSGKSEDDNYLALSNSKGEFLLNGDFVVSMSKREVRVGSAVIEYSGSDNVVERLNCTDRIEEELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERRRKLVCTRESDQLTVSDQRCDRLPQPGPVTEACGTDCDLRWHVASKSECSAQCGLGYRTLDIHCAKYSRMDGKTEKVDDSFCSSQPRPSNQEKCSGECSTGGWRYSAWTECSRSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVVVQSCNEFSCPHWKTGDWSECLVTCGKGHKHRQVWCQFGEDRLSDRMCDPEAKPEPMQTCQQPECAAWQAGPWGQCSVTCGQGYQLRAVKCIMGTYMSVVDDNDCNAATRPTDTQDCELASCHPSILALEPRRNAQSIPRTQWRFGSWTPCSATCGKGTRMRYVSCRDEDGSVADESACATLPKPVAKEECSVTPCGQWKALDWSSCSVTCGQGKATRQVVCVNYSDHVIDRSECDPDYIPETDQDCSMSPCPQWTGLAHPFQNEDFRPRSDSPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGSWGECTKLCGGGMRTRLVVCQRANGDRFPDLSCEVLDKPTDREQCNTHACPQDAAWSTGPWSSCSVSCGRGHKHRNVYCLAKDGSHLESDNCKHLPKPHGHRRCRGGRCPRWKAGAWSQCSVSCGQGVQQRHVGCQIGTHKAARESECSSYSRPESERVCQASPCPLYTWRAEQWQQCTKTCGEGSRYRQVVCVAEDQSEVHSTHCDSDQRPPDRESCSLQPCEYVWITGEWSECSVTCGKGYRQRLVSCSEIYTGKENYEYSYQTTVNCPGAQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGIGVMHRSVQCLTNEDQPSHLCPTDTKPEERKACRNVYNCELPQNCKEVKKLNSASVDGEYFLAVRGKPLKVFCAGMNSDYPKEYVTLAHGDSENFSEVYGHRLHNPTECPYNGSRRDDCHCRKDYTAAGFSSFQKIRLDLTSMQIITTDLEFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWTSQGNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRVS | ||||||
Disulfide bond | 368↔418 | |||||
Sequence: CQWQHSKNYLGGIQHDTAVLVTREDICRAQDKCDTLGLAELGTICDPYRSC | ||||||
Disulfide bond | 394↔400 | |||||
Sequence: CRAQDKC | ||||||
Disulfide bond | 412↔494 | |||||
Sequence: CDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDSNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGEC | ||||||
Disulfide bond | 450↔478 | |||||
Sequence: CKEEGVKSPQHVMAPTLNFYTNPWMWSKC | ||||||
Disulfide bond | 521↔543 | |||||
Sequence: CELIFGPGSQVCPYMMQCRRLWC | ||||||
Disulfide bond | 532↔553 | |||||
Sequence: CPYMMQCRRLWCNNVDGAHKGC | ||||||
Disulfide bond | 538↔572 | |||||
Sequence: CRRLWCNNVDGAHKGCRTQHTPWADGTECEPGKHC | ||||||
Disulfide bond | 566↔577 | |||||
Sequence: CEPGKHCKFGFC | ||||||
Disulfide bond | 600↔637 | |||||
Sequence: CSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSC | ||||||
Disulfide bond | 604↔642 | |||||
Sequence: CGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPC | ||||||
Disulfide bond | 615↔627 | |||||
Sequence: CNRPEPKNGGKYC |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 210-236 | Disordered | ||||
Sequence: STPQREPSTGKHACATSELKNSHSKDK | ||||||
Compositional bias | 211-226 | Polar residues | ||||
Sequence: TPQREPSTGKHACATS | ||||||
Domain | 293-499 | Peptidase M12B | ||||
Sequence: RFVEVMVVADHRMVLYHGANLQHYILTLMSIVASIYKDSSIGNLINIVIVNLVVIHNEQEGPYINFNAQTTLKNFCQWQHSKNYLGGIQHDTAVLVTREDICRAQDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDSNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEP | ||||||
Domain | 1731-1931 | GON | ||||
Sequence: LPQNCKEVKKLNSASVDGEYFLAVRGKPLKVFCAGMNSDYPKEYVTLAHGDSENFSEVYGHRLHNPTECPYNGSRRDDCHCRKDYTAAGFSSFQKIRLDLTSMQIITTDLEFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWTSQGNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRVS |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,931
- Mass (Da)215,753
- Last updated2011-04-05 v1
- Checksum40359B1314F1CF61
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E9PYV8 | E9PYV8_MOUSE | Adamts9 | 1350 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 211-226 | Polar residues | ||||
Sequence: TPQREPSTGKHACATS |
Keywords
- Technical term